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- W2893360810 abstract "Pseudorabies virus (PRV) is an alphaherpesvirus related to human pathogens such as herpes simplex virus 1 and varicella-zoster virus (VZV). The natural host of PRV is the swine, but it can infect most mammals. In susceptible animals other than pigs, PRV infection always causes a characteristic lethal pruritus known as the “mad itch.” The role of the immune response in the clinical outcome of PRV infection is still poorly understood. Here, we show that a systemic host inflammatory response is responsible for the severe pruritus and acute death of mice infected with virulent PRV-Becker but not mice infected with attenuated strain PRV-Bartha. In addition, we identified IL-6 and G-CSF as two main cytokines that play crucial roles in the regulation of this process. Our findings give new insights into neuroinflammatory diseases and strengthen further the similarities between VZV and PRV infections at the level of innate immunity." @default.
- W2893360810 created "2018-10-05" @default.
- W2893360810 creator A5017047191 @default.
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- W2893360810 date "2018-12-15" @default.
- W2893360810 modified "2023-10-18" @default.
- W2893360810 title "Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice" @default.
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- W2893360810 doi "https://doi.org/10.1128/jvi.01614-18" @default.
- W2893360810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258956" @default.
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- W2893360810 hasPublicationYear "2018" @default.
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