FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893365638> ?p ?o ?g. }

• W2893365638 endingPage "2574" @default.
• W2893365638 startingPage "2564" @default.
• W2893365638 abstract "The mechanistic target of rapamycin (mTOR) is a central regulator of cellular proliferation and metabolism. Depending on its binding partners, mTOR is at the core of 2 complexes that either promote protein biosynthesis (mTOR complex 1; mTORC1) or provide survival and proliferation signals (mTORC2). Protein biosynthesis downstream of mTORC1 plays an important role in MYC-driven oncogenesis with translation inhibitors garnering increasing therapeutic attention. The germinal center B-cell oncogene UCHL1 encodes a deubiquitinating enzyme that regulates the balance between mTOR complexes by disrupting mTORC1 and promoting mTORC2 assembly. While supporting mTORC2-dependent growth and survival signals may contribute to its role in cancer, the suppression of mTORC1 activity is enigmatic, as its phosphorylation of its substrate 4EBP1 promotes protein biosynthesis. To address this, we used proximity-based proteomics to identify molecular complexes with which UCH-L1 associates in malignant B cells. We identified a novel association of UCH-L1 with the translation initiation complex eIF4F, the target of 4EBP1. UCH-L1 associates with and promotes the assembly of eIF4F and stimulates protein synthesis through a mechanism that requires its catalytic activity. Because of the importance of mTOR in MYC-driven oncogenesis, we used novel mutant Uchl1 transgenic mice and found that catalytic activity is required for its acceleration of lymphoma in the Eμ-myc model. Further, we demonstrate that mice lacking UCH-L1 are resistant to MYC-induced lymphomas. We conclude that UCH-L1 bypasses the need for mTORC1-dependent protein synthesis by directly promoting translation initiation, and that this mechanism may be essential for MYC in B-cell malignancy." @default.
• W2893365638 created "2018-10-05" @default.
• W2893365638 creator A5001969998 @default.
• W2893365638 creator A5021419381 @default.
• W2893365638 creator A5026023198 @default.
• W2893365638 creator A5027265757 @default.
• W2893365638 creator A5027906141 @default.
• W2893365638 creator A5045828609 @default.
• W2893365638 creator A5051491336 @default.
• W2893365638 creator A5053223762 @default.
• W2893365638 creator A5072068316 @default.
• W2893365638 creator A5084642339 @default.
• W2893365638 date "2018-12-13" @default.
• W2893365638 modified "2023-10-10" @default.
• W2893365638 title "UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice" @default.
• W2893365638 cites W1511827873 @default.
• W2893365638 cites W1555476635 @default.
• W2893365638 cites W1963688091 @default.
• W2893365638 cites W1966826063 @default.
• W2893365638 cites W1968075576 @default.
• W2893365638 cites W1971543885 @default.
• W2893365638 cites W1972548761 @default.
• W2893365638 cites W1982789056 @default.
• W2893365638 cites W1998530321 @default.
• W2893365638 cites W2000731858 @default.
• W2893365638 cites W2021669986 @default.
• W2893365638 cites W2030802073 @default.
• W2893365638 cites W2034774838 @default.
• W2893365638 cites W2042066283 @default.
• W2893365638 cites W2047200931 @default.
• W2893365638 cites W2047311424 @default.
• W2893365638 cites W2049085719 @default.
• W2893365638 cites W2053304186 @default.
• W2893365638 cites W2057650061 @default.
• W2893365638 cites W2065825082 @default.
• W2893365638 cites W2070181143 @default.
• W2893365638 cites W2079838847 @default.
• W2893365638 cites W2091213817 @default.
• W2893365638 cites W2095253522 @default.
• W2893365638 cites W2102028478 @default.
• W2893365638 cites W2114492564 @default.
• W2893365638 cites W2130935241 @default.
• W2893365638 cites W2137383307 @default.
• W2893365638 cites W2139682891 @default.
• W2893365638 cites W2151867596 @default.
• W2893365638 cites W2162723598 @default.
• W2893365638 cites W2172697812 @default.
• W2893365638 cites W2220838850 @default.
• W2893365638 cites W2304846645 @default.
• W2893365638 cites W2593816418 @default.
• W2893365638 cites W2612937617 @default.
• W2893365638 cites W2645161928 @default.
• W2893365638 cites W2767935554 @default.
• W2893365638 cites W2772104082 @default.
• W2893365638 cites W2779766047 @default.
• W2893365638 doi "https://doi.org/10.1182/blood-2018-05-848515" @default.
• W2893365638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6293873" @default.
• W2893365638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257881" @default.
• W2893365638 hasPublicationYear "2018" @default.
• W2893365638 type Work @default.
• W2893365638 sameAs 2893365638 @default.
• W2893365638 citedByCount "26" @default.
• W2893365638 countsByYear W28933656382018 @default.
• W2893365638 countsByYear W28933656382019 @default.
• W2893365638 countsByYear W28933656382020 @default.
• W2893365638 countsByYear W28933656382021 @default.
• W2893365638 countsByYear W28933656382022 @default.
• W2893365638 countsByYear W28933656382023 @default.
• W2893365638 crossrefType "journal-article" @default.
• W2893365638 hasAuthorship W2893365638A5001969998 @default.
• W2893365638 hasAuthorship W2893365638A5021419381 @default.
• W2893365638 hasAuthorship W2893365638A5026023198 @default.
• W2893365638 hasAuthorship W2893365638A5027265757 @default.
• W2893365638 hasAuthorship W2893365638A5027906141 @default.
• W2893365638 hasAuthorship W2893365638A5045828609 @default.
• W2893365638 hasAuthorship W2893365638A5051491336 @default.
• W2893365638 hasAuthorship W2893365638A5053223762 @default.
• W2893365638 hasAuthorship W2893365638A5072068316 @default.
• W2893365638 hasAuthorship W2893365638A5084642339 @default.
• W2893365638 hasBestOaLocation W28933656381 @default.
• W2893365638 hasConcept C104317684 @default.
• W2893365638 hasConcept C107846503 @default.
• W2893365638 hasConcept C2777949483 @default.
• W2893365638 hasConcept C3675279 @default.
• W2893365638 hasConcept C502942594 @default.
• W2893365638 hasConcept C55493867 @default.
• W2893365638 hasConcept C555283112 @default.
• W2893365638 hasConcept C62478195 @default.
• W2893365638 hasConcept C86554907 @default.
• W2893365638 hasConcept C86803240 @default.
• W2893365638 hasConcept C95444343 @default.
• W2893365638 hasConcept C98490376 @default.
• W2893365638 hasConceptScore W2893365638C104317684 @default.
• W2893365638 hasConceptScore W2893365638C107846503 @default.
• W2893365638 hasConceptScore W2893365638C2777949483 @default.
• W2893365638 hasConceptScore W2893365638C3675279 @default.
• W2893365638 hasConceptScore W2893365638C502942594 @default.
• W2893365638 hasConceptScore W2893365638C55493867 @default.

• next