Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893371210> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2893371210 endingPage "942" @default.
- W2893371210 startingPage "933" @default.
- W2893371210 abstract "Asthma is the inflammatory disorder of airways highly prevalent in both, children and adults all over the world. The aim of this study was to investigate the serum proteome for the identification of proteins contributing to the pathogenesis of non-atopic asthma.Protein expression profiling of sera from non-atopic asthmatic patients (n=73) and controls (n=99) was carried out using 1D SDS PAGE. Differentially expressed protein bands were compared with controls, cut from the gel and identified by LC-Q-TOF_MSMS analysis.Various acute phase proteins (i.e., haptoglobin, transthyretin, serum amyloid A, and serum albumin), retinol binding protein 4 (RBP4), Ig gamma-1-chain C-region, hemoglobin subunit β, complement system components (C8 gamma chain and C4-A), ApoA-1 and Ig κ chain C-region containing protein fractions were predominantly down-regulated in asthmatic patients. Similarly, a higher proportion of male patients exhibited down-regulation of all other (except albumin and C4-A containing) protein fractions as compared to female patients. However, fractions consisting of another acute phase protein, inter-alpha-trypsin heavy chain 4 (ITIH4) and complement system component C3 were up-regulated in the majority of patients.Our study is the first to confirm the role of thyroxine (TTR), retinol (RBP4), cholesterol (apoA-1) transporting proteins, inflammation and its mediators in the pathogenesis of asthma. Further study may help to improve diagnosis and plan better treatment strategies." @default.
- W2893371210 created "2018-10-05" @default.
- W2893371210 creator A5014382715 @default.
- W2893371210 creator A5032045710 @default.
- W2893371210 creator A5034683365 @default.
- W2893371210 creator A5046291388 @default.
- W2893371210 date "2018-11-30" @default.
- W2893371210 modified "2023-10-12" @default.
- W2893371210 title "Serum Proteome Profiling to Identify Proteins Promoting Pathogenesis of Non-atopic Asthma" @default.
- W2893371210 doi "https://doi.org/10.2174/0929866525666180925142119" @default.
- W2893371210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30255743" @default.
- W2893371210 hasPublicationYear "2018" @default.
- W2893371210 type Work @default.
- W2893371210 sameAs 2893371210 @default.
- W2893371210 citedByCount "6" @default.
- W2893371210 countsByYear W28933712102019 @default.
- W2893371210 countsByYear W28933712102020 @default.
- W2893371210 countsByYear W28933712102021 @default.
- W2893371210 countsByYear W28933712102022 @default.
- W2893371210 crossrefType "journal-article" @default.
- W2893371210 hasAuthorship W2893371210A5014382715 @default.
- W2893371210 hasAuthorship W2893371210A5032045710 @default.
- W2893371210 hasAuthorship W2893371210A5034683365 @default.
- W2893371210 hasAuthorship W2893371210A5046291388 @default.
- W2893371210 hasConcept C104397665 @default.
- W2893371210 hasConcept C121157162 @default.
- W2893371210 hasConcept C126322002 @default.
- W2893371210 hasConcept C185592680 @default.
- W2893371210 hasConcept C20299238 @default.
- W2893371210 hasConcept C203014093 @default.
- W2893371210 hasConcept C206396517 @default.
- W2893371210 hasConcept C2776042228 @default.
- W2893371210 hasConcept C2776125364 @default.
- W2893371210 hasConcept C2776914184 @default.
- W2893371210 hasConcept C2776940978 @default.
- W2893371210 hasConcept C2776946954 @default.
- W2893371210 hasConcept C2779573558 @default.
- W2893371210 hasConcept C2780029684 @default.
- W2893371210 hasConcept C2780942790 @default.
- W2893371210 hasConcept C2781195455 @default.
- W2893371210 hasConcept C55359608 @default.
- W2893371210 hasConcept C55493867 @default.
- W2893371210 hasConcept C57194454 @default.
- W2893371210 hasConcept C71924100 @default.
- W2893371210 hasConcept C8891405 @default.
- W2893371210 hasConcept C97749175 @default.
- W2893371210 hasConceptScore W2893371210C104397665 @default.
- W2893371210 hasConceptScore W2893371210C121157162 @default.
- W2893371210 hasConceptScore W2893371210C126322002 @default.
- W2893371210 hasConceptScore W2893371210C185592680 @default.
- W2893371210 hasConceptScore W2893371210C20299238 @default.
- W2893371210 hasConceptScore W2893371210C203014093 @default.
- W2893371210 hasConceptScore W2893371210C206396517 @default.
- W2893371210 hasConceptScore W2893371210C2776042228 @default.
- W2893371210 hasConceptScore W2893371210C2776125364 @default.
- W2893371210 hasConceptScore W2893371210C2776914184 @default.
- W2893371210 hasConceptScore W2893371210C2776940978 @default.
- W2893371210 hasConceptScore W2893371210C2776946954 @default.
- W2893371210 hasConceptScore W2893371210C2779573558 @default.
- W2893371210 hasConceptScore W2893371210C2780029684 @default.
- W2893371210 hasConceptScore W2893371210C2780942790 @default.
- W2893371210 hasConceptScore W2893371210C2781195455 @default.
- W2893371210 hasConceptScore W2893371210C55359608 @default.
- W2893371210 hasConceptScore W2893371210C55493867 @default.
- W2893371210 hasConceptScore W2893371210C57194454 @default.
- W2893371210 hasConceptScore W2893371210C71924100 @default.
- W2893371210 hasConceptScore W2893371210C8891405 @default.
- W2893371210 hasConceptScore W2893371210C97749175 @default.
- W2893371210 hasIssue "10" @default.
- W2893371210 hasLocation W28933712101 @default.
- W2893371210 hasLocation W28933712102 @default.
- W2893371210 hasOpenAccess W2893371210 @default.
- W2893371210 hasPrimaryLocation W28933712101 @default.
- W2893371210 hasRelatedWork W1965747238 @default.
- W2893371210 hasRelatedWork W1978604713 @default.
- W2893371210 hasRelatedWork W1987233437 @default.
- W2893371210 hasRelatedWork W2089441983 @default.
- W2893371210 hasRelatedWork W2171649931 @default.
- W2893371210 hasRelatedWork W2186203530 @default.
- W2893371210 hasRelatedWork W2186899866 @default.
- W2893371210 hasRelatedWork W2256634873 @default.
- W2893371210 hasRelatedWork W2304657935 @default.
- W2893371210 hasRelatedWork W26521452 @default.
- W2893371210 hasVolume "25" @default.
- W2893371210 isParatext "false" @default.
- W2893371210 isRetracted "false" @default.
- W2893371210 magId "2893371210" @default.
- W2893371210 workType "article" @default.