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- W2893388188 abstract "We read with interest the work conducted by Soldano and colleagues,1 exploring M1/M2 macrophage surface markers in circulating blood cells in systemic sclerosis (SSc). Using a wide phenotypic characterisation of circulating cells by flow cytometry, the authors highlight that the percentage of CD14+ cells coexpressing M2 markers (CD206, CD163 and CD204) and M1 markers (TLR4) is higher in patients with SSc than in healthy subjects (HSs). Similarly, CD204+ circulating cells coexpressing M2 markers (CD163, CD206) and M1 markers (TLR4, CD80, CD86) were also over-represented in patients with SSc. These results strengthen the concept of a specific macrophage signature in SSc which goes beyond the dichotomous M1/M2 paradigm.2–4 However, this study was only conducted on undifferentiated circulating blood cells and the validation of their results on differentiated macrophages is still to be determined.In support of Soldano’s results,1 we present here, a phenotypic analysis conducted on macrophage-colony stimulating factor (M-CSF) resting blood monocyte-derived macrophages (MDM) from glucocorticoid (GC)-free patients fulfilling ACR/EULAR 2013 classification criteria for SSc in comparison with HSs, evaluating the mean of fluorescence intensity (MFI) ratio of six polarisation markers (CD80, CD206, CD204, CD163, CD169 and CD200R1) and supporting the existence of a mixed M1/M2 signature in SSc MDM. In …" @default.
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- W2893388188 date "2018-09-29" @default.
- W2893388188 modified "2023-10-07" @default.
- W2893388188 title "M1/M2 polarisation state of M-CSF blood-derived macrophages in systemic sclerosis" @default.
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- W2893388188 doi "https://doi.org/10.1136/annrheumdis-2018-214333" @default.
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