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• W2893389983 abstract "Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endoplasmic reticulum (ER) is an organelle involved in protein folding, calcium homeostasis, and lipid biosynthesis. Protein disulfide isomerase (PDI) is a molecular chaperone induced and activated by ER stress. PDI is induced by hypoxia in neuronal, cardiac, and endothelial cells, supporting increased cell survival to hypoxic stress and protection from apoptosis in response to ischemia. We achieved ex vivo PDI gene transfer into luciferase-expressing myoblasts and endothelial cells. We assessed cell engraftment upon intramuscular transplantation into a mouse model of Duchenne muscular dystrophy (mdx mouse) and into a mouse model of ischemic disease. We observed that loss of full-length dystrophin expression in mdx mice muscle leads to an increase of PDI expression, possibly in response to augmented ER protein folding load. Moreover, we determined that overexpression of PDI confers a survival advantage for muscle cells in vitro and in vivo to human myoblasts injected into murine dystrophic muscle and to endothelial cells administered upon hindlimb ischemia damage, improving the therapeutic outcome of the cell therapy treatment. Collectively, these results suggest that overexpression of PDI may protect transplanted cells from hypoxia and other possibly occurring ER stresses, and consequently enhance their regenerative properties." @default.
• W2893389983 created "2018-10-05" @default.
• W2893389983 creator A5020273307 @default.
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• W2893389983 creator A5043662056 @default.
• W2893389983 creator A5048926232 @default.
• W2893389983 date "2018-09-26" @default.
• W2893389983 modified "2023-10-16" @default.
• W2893389983 title "Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases" @default.
• W2893389983 cites W109749587 @default.
• W2893389983 cites W1582272383 @default.
• W2893389983 cites W1596505224 @default.
• W2893389983 cites W1697178647 @default.
• W2893389983 cites W1924112666 @default.
• W2893389983 cites W1964229043 @default.
• W2893389983 cites W1964695883 @default.
• W2893389983 cites W1966996818 @default.
• W2893389983 cites W1970641734 @default.
• W2893389983 cites W1976161806 @default.
• W2893389983 cites W1976324142 @default.
• W2893389983 cites W1979158821 @default.
• W2893389983 cites W1989181950 @default.
• W2893389983 cites W1992050281 @default.
• W2893389983 cites W1997168081 @default.
• W2893389983 cites W2004205775 @default.
• W2893389983 cites W2007398635 @default.
• W2893389983 cites W2010916136 @default.
• W2893389983 cites W2014235417 @default.
• W2893389983 cites W2022087931 @default.
• W2893389983 cites W2027570273 @default.
• W2893389983 cites W2028568142 @default.
• W2893389983 cites W2029007648 @default.
• W2893389983 cites W2041831348 @default.
• W2893389983 cites W2056431144 @default.
• W2893389983 cites W2057153598 @default.
• W2893389983 cites W2065098729 @default.
• W2893389983 cites W2066810285 @default.
• W2893389983 cites W2067434070 @default.
• W2893389983 cites W2083542905 @default.
• W2893389983 cites W2092487631 @default.
• W2893389983 cites W2093398011 @default.
• W2893389983 cites W2098720707 @default.
• W2893389983 cites W2100250587 @default.
• W2893389983 cites W2121189093 @default.
• W2893389983 cites W2132628525 @default.
• W2893389983 cites W2136315377 @default.
• W2893389983 cites W2142488497 @default.
• W2893389983 cites W2144827966 @default.
• W2893389983 cites W2147742177 @default.
• W2893389983 cites W2148717351 @default.
• W2893389983 cites W2149479293 @default.
• W2893389983 cites W2149924486 @default.
• W2893389983 cites W2152940256 @default.
• W2893389983 cites W2155901302 @default.
• W2893389983 cites W2165064047 @default.
• W2893389983 cites W2165168956 @default.
• W2893389983 cites W2169367947 @default.
• W2893389983 cites W2169734476 @default.
• W2893389983 cites W2171281605 @default.
• W2893389983 cites W2192080449 @default.
• W2893389983 cites W2194012442 @default.
• W2893389983 cites W2206766868 @default.
• W2893389983 cites W2222830543 @default.
• W2893389983 cites W2263405800 @default.
• W2893389983 cites W2281133656 @default.
• W2893389983 cites W2292633092 @default.
• W2893389983 cites W2324783945 @default.
• W2893389983 cites W2339605709 @default.
• W2893389983 cites W2346705222 @default.
• W2893389983 cites W2397208862 @default.
• W2893389983 cites W2474207607 @default.
• W2893389983 cites W2512273774 @default.
• W2893389983 cites W2520531699 @default.
• W2893389983 cites W2560690741 @default.
• W2893389983 cites W2561514889 @default.
• W2893389983 cites W2586106736 @default.
• W2893389983 cites W2591529906 @default.
• W2893389983 cites W2603408230 @default.
• W2893389983 cites W2607662251 @default.
• W2893389983 cites W2612867295 @default.
• W2893389983 cites W2617594540 @default.
• W2893389983 cites W2625219423 @default.
• W2893389983 cites W2759535657 @default.
• W2893389983 cites W2772528916 @default.
• W2893389983 cites W2774342749 @default.
• W2893389983 cites W2780401357 @default.
• W2893389983 cites W2785325647 @default.
• W2893389983 cites W2804784552 @default.
• W2893389983 cites W2808964520 @default.
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• W2893389983 doi "https://doi.org/10.1186/s13287-018-0986-y" @default.
• W2893389983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158916" @default.
• W2893389983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257707" @default.
• W2893389983 hasPublicationYear "2018" @default.
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