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- W2893394744 abstract "Alzheimer's disease (AD) is the most common type of dementia affecting regions of the central nervous system that exhibit synaptic plasticity and are involved in higher brain functions such as learning and memory. AD is characterized by progressive cognitive dysfunction, memory loss and behavioral disturbances of synaptic plasticity and energy metabolism. Cell therapy has emerged as an alternative treatment of AD. The use of adult stem cells, such as neural stem cells and Mesenchymal Stem Cells (MSCs) from bone marrow and adipose tissue, have the potential to decrease cognitive deficits, possibly by reducing neuronal loss through blocking apoptosis, increasing neurogenesis, synaptogenesis and angiogenesis. These processes are mediated primarily by the secretion of many growth factors, anti-inflammatory proteins, membrane receptors, microRNAs (miRNA) and exosomes. Exosomes encapsulate and transfer several functional molecules like proteins, lipids and regulatory RNA which can modify cell metabolism. In the proteomic characterization of the content of MSC-derived exosomes, more than 730 proteins have been identified, some of which are specific cell type markers and others are involved in the regulation of binding and fusion of exosomes with adjacent cells. Furthermore, some factors were found that promote the recruitment, proliferation and differentiation of other cells like neural stem cells. Moreover, within exosomal cargo, a wide range of miRNAs were found, which can control functions related to neural remodeling as well as angiogenic and neurogenic processes. Taking this into consideration, the use of exosomes could be part of a strategy to promote neuroplasticity, improve cognitive impairment and neural replacement in AD. In this review, we describe how exosomes are involved in AD pathology and discuss the therapeutic potential of MSC-derived exosomes mediated by miRNA and protein cargo." @default.
- W2893394744 created "2018-10-05" @default.
- W2893394744 creator A5026992178 @default.
- W2893394744 creator A5030768949 @default.
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- W2893394744 creator A5056976988 @default.
- W2893394744 creator A5060657924 @default.
- W2893394744 creator A5075483290 @default.
- W2893394744 date "2018-09-24" @default.
- W2893394744 modified "2023-10-16" @default.
- W2893394744 title "Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease" @default.
- W2893394744 cites W1483803290 @default.
- W2893394744 cites W1525948836 @default.
- W2893394744 cites W1539173139 @default.
- W2893394744 cites W1559752086 @default.
- W2893394744 cites W1591297143 @default.
- W2893394744 cites W1744236062 @default.
- W2893394744 cites W1803510593 @default.
- W2893394744 cites W1816689036 @default.
- W2893394744 cites W1832220924 @default.
- W2893394744 cites W1911973481 @default.
- W2893394744 cites W1914452730 @default.
- W2893394744 cites W1933828059 @default.
- W2893394744 cites W1955004709 @default.
- W2893394744 cites W1968670053 @default.
- W2893394744 cites W1970368333 @default.
- W2893394744 cites W1971744915 @default.
- W2893394744 cites W1975257189 @default.
- W2893394744 cites W1979345067 @default.
- W2893394744 cites W1979751563 @default.
- W2893394744 cites W1980798766 @default.
- W2893394744 cites W1983286754 @default.
- W2893394744 cites W1983769449 @default.
- W2893394744 cites W1984807833 @default.
- W2893394744 cites W1985124617 @default.
- W2893394744 cites W1985844219 @default.
- W2893394744 cites W1989375959 @default.
- W2893394744 cites W1991316122 @default.
- W2893394744 cites W1993103003 @default.
- W2893394744 cites W1999925406 @default.
- W2893394744 cites W2001082025 @default.
- W2893394744 cites W2003343932 @default.
- W2893394744 cites W2005792762 @default.
- W2893394744 cites W2009755157 @default.
- W2893394744 cites W2010764365 @default.
- W2893394744 cites W2012658246 @default.
- W2893394744 cites W2013017425 @default.
- W2893394744 cites W2013513553 @default.
- W2893394744 cites W2016008005 @default.
- W2893394744 cites W2024510006 @default.
- W2893394744 cites W2027891737 @default.
- W2893394744 cites W2028248159 @default.
- W2893394744 cites W2030508474 @default.
- W2893394744 cites W2031337312 @default.
- W2893394744 cites W2032735323 @default.
- W2893394744 cites W2036755018 @default.
- W2893394744 cites W2047159195 @default.
- W2893394744 cites W2047405780 @default.
- W2893394744 cites W2048560678 @default.
- W2893394744 cites W2049369927 @default.
- W2893394744 cites W2054880213 @default.
- W2893394744 cites W2055424631 @default.
- W2893394744 cites W2058999179 @default.
- W2893394744 cites W2060458492 @default.
- W2893394744 cites W2065236536 @default.
- W2893394744 cites W2070795670 @default.
- W2893394744 cites W207124143 @default.
- W2893394744 cites W2072738655 @default.
- W2893394744 cites W2074156609 @default.
- W2893394744 cites W2078798753 @default.
- W2893394744 cites W2087433406 @default.
- W2893394744 cites W2091196588 @default.
- W2893394744 cites W2093271417 @default.
- W2893394744 cites W2094618353 @default.
- W2893394744 cites W2094711438 @default.
- W2893394744 cites W2095221339 @default.
- W2893394744 cites W2095598251 @default.
- W2893394744 cites W2096913878 @default.
- W2893394744 cites W2098259366 @default.
- W2893394744 cites W2100421640 @default.
- W2893394744 cites W2101027374 @default.
- W2893394744 cites W2101717161 @default.
- W2893394744 cites W2103913931 @default.
- W2893394744 cites W2108493635 @default.
- W2893394744 cites W2109691647 @default.
- W2893394744 cites W2116489432 @default.
- W2893394744 cites W2119043140 @default.
- W2893394744 cites W2119376007 @default.
- W2893394744 cites W2119764013 @default.
- W2893394744 cites W2124019813 @default.
- W2893394744 cites W2124925707 @default.
- W2893394744 cites W2127789180 @default.
- W2893394744 cites W2128891846 @default.
- W2893394744 cites W2132537459 @default.
- W2893394744 cites W2142594288 @default.
- W2893394744 cites W2142623116 @default.
- W2893394744 cites W2146548883 @default.
- W2893394744 cites W2152546971 @default.
- W2893394744 cites W2155023773 @default.
- W2893394744 cites W2156281143 @default.