FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893396116> ?p ?o ?g. }

• W2893396116 endingPage "553" @default.
• W2893396116 startingPage "545" @default.
• W2893396116 abstract "Abstract Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells and named them MG-63/Dox and HOS/Dox, respectively. The Dox resistant OS cells had greater invasion ability than that of parental cells. The expression of ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased in Dox resistant OS cells. Silencing of ZEB1 can attenuate the metastasis and increase Dox sensitivity of MG-63/Dox and HOS/Dox cells. The upregulation of ZEB1 can increase of the expression of interlukin-6 (IL-6). Anti-IL-6 inhibited the invasion and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. There was no significant difference of ZEB1 mRNA between Dox resistant and control cells. The upregulation of ZEB1 in Dox resistant OS cells can be attributed to the increase of protein half-life. This was confirmed by results that the inhibitor of proteasomal degradation can increase ZEB1 in Dox resistant OS cells. Over expression of SIAH1 can inhibit the expression of ZEB1 and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. Collectively, we confirmed that SIAH1 induced ZEB1 is involved in the Dox resistance of OS cells." @default.
• W2893396116 created "2018-10-05" @default.
• W2893396116 creator A5014661038 @default.
• W2893396116 creator A5017190999 @default.
• W2893396116 creator A5018297744 @default.
• W2893396116 creator A5046383322 @default.
• W2893396116 creator A5077819266 @default.
• W2893396116 creator A5089966579 @default.
• W2893396116 date "2018-10-11" @default.
• W2893396116 modified "2023-10-11" @default.
• W2893396116 title "SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells" @default.
• W2893396116 cites W1498143688 @default.
• W2893396116 cites W1621930076 @default.
• W2893396116 cites W1804495077 @default.
• W2893396116 cites W1978166647 @default.
• W2893396116 cites W1986690159 @default.
• W2893396116 cites W2033878783 @default.
• W2893396116 cites W2047172303 @default.
• W2893396116 cites W2050769654 @default.
• W2893396116 cites W2084887656 @default.
• W2893396116 cites W2100751052 @default.
• W2893396116 cites W2103324798 @default.
• W2893396116 cites W2123434257 @default.
• W2893396116 cites W2128486176 @default.
• W2893396116 cites W2134287597 @default.
• W2893396116 cites W2178308549 @default.
• W2893396116 cites W2203541991 @default.
• W2893396116 cites W2526675675 @default.
• W2893396116 cites W2555627105 @default.
• W2893396116 cites W2564004562 @default.
• W2893396116 cites W2565210690 @default.
• W2893396116 cites W2611513137 @default.
• W2893396116 cites W2624795855 @default.
• W2893396116 cites W2734283649 @default.
• W2893396116 cites W2739497725 @default.
• W2893396116 cites W70114090 @default.
• W2893396116 doi "https://doi.org/10.1515/hsz-2018-0292" @default.
• W2893396116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30265649" @default.
• W2893396116 hasPublicationYear "2018" @default.
• W2893396116 type Work @default.
• W2893396116 sameAs 2893396116 @default.
• W2893396116 citedByCount "11" @default.
• W2893396116 countsByYear W28933961162019 @default.
• W2893396116 countsByYear W28933961162020 @default.
• W2893396116 countsByYear W28933961162021 @default.
• W2893396116 countsByYear W28933961162022 @default.
• W2893396116 crossrefType "journal-article" @default.
• W2893396116 hasAuthorship W2893396116A5014661038 @default.
• W2893396116 hasAuthorship W2893396116A5017190999 @default.
• W2893396116 hasAuthorship W2893396116A5018297744 @default.
• W2893396116 hasAuthorship W2893396116A5046383322 @default.
• W2893396116 hasAuthorship W2893396116A5077819266 @default.
• W2893396116 hasAuthorship W2893396116A5089966579 @default.
• W2893396116 hasConcept C104317684 @default.
• W2893396116 hasConcept C119056186 @default.
• W2893396116 hasConcept C121608353 @default.
• W2893396116 hasConcept C126322002 @default.
• W2893396116 hasConcept C127561419 @default.
• W2893396116 hasConcept C153911025 @default.
• W2893396116 hasConcept C185592680 @default.
• W2893396116 hasConcept C2776694085 @default.
• W2893396116 hasConcept C2777760704 @default.
• W2893396116 hasConcept C2779013556 @default.
• W2893396116 hasConcept C2781303535 @default.
• W2893396116 hasConcept C502942594 @default.
• W2893396116 hasConcept C55493867 @default.
• W2893396116 hasConcept C71924100 @default.
• W2893396116 hasConcept C86803240 @default.
• W2893396116 hasConceptScore W2893396116C104317684 @default.
• W2893396116 hasConceptScore W2893396116C119056186 @default.
• W2893396116 hasConceptScore W2893396116C121608353 @default.
• W2893396116 hasConceptScore W2893396116C126322002 @default.
• W2893396116 hasConceptScore W2893396116C127561419 @default.
• W2893396116 hasConceptScore W2893396116C153911025 @default.
• W2893396116 hasConceptScore W2893396116C185592680 @default.
• W2893396116 hasConceptScore W2893396116C2776694085 @default.
• W2893396116 hasConceptScore W2893396116C2777760704 @default.
• W2893396116 hasConceptScore W2893396116C2779013556 @default.
• W2893396116 hasConceptScore W2893396116C2781303535 @default.
• W2893396116 hasConceptScore W2893396116C502942594 @default.
• W2893396116 hasConceptScore W2893396116C55493867 @default.
• W2893396116 hasConceptScore W2893396116C71924100 @default.
• W2893396116 hasConceptScore W2893396116C86803240 @default.
• W2893396116 hasIssue "4" @default.
• W2893396116 hasLocation W28933961161 @default.
• W2893396116 hasOpenAccess W2893396116 @default.
• W2893396116 hasPrimaryLocation W28933961161 @default.
• W2893396116 hasRelatedWork W2006087775 @default.
• W2893396116 hasRelatedWork W2028961521 @default.
• W2893396116 hasRelatedWork W2076364617 @default.
• W2893396116 hasRelatedWork W2418660320 @default.
• W2893396116 hasRelatedWork W2740221126 @default.
• W2893396116 hasRelatedWork W2961055807 @default.
• W2893396116 hasRelatedWork W3027839554 @default.
• W2893396116 hasRelatedWork W3215845635 @default.
• W2893396116 hasRelatedWork W4292236581 @default.
• W2893396116 hasRelatedWork W4382520280 @default.
• W2893396116 hasVolume "400" @default.

• next