FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893396791> ?p ?o ?g. }

• W2893396791 abstract "We evaluated the impact of variations in ATG16L1 and NOD2 and genes on serologic responses in patients with inflammatory bowel disease (IBD).We recruited 308 IBD patients: 130 with Crohn's disease (CD), 67 with ulcerative colitis (UC), 111 with UC and an ileal pouch (UC-pouch), and 74 healthy controls. NOD2 variants (1007fs, G908R, R702W) and the ATG16L1 A300T variant were analyzed. The antiglycan antibodies anti-Saccharomyces cerevisiae (ASCA), antilaminaribioside (ALCA), antichitobioside (ACCA), and antimannobioside carbohydrate (AMCA) were analyzed by enzyme-linked immunosorbent assay.Antichitobioside was positive in 28% of patients with CD carrying the ATG16L1 A300T variant (either heterozygote or homozygote) compared with only 3% in those without the variant (P < 0.001). Anti-Saccharomyces cerevisiae was positive in 86% of patients with CD carrying the NOD2 1007fs variant compared with 36% in those without the variant (P < 0.001). UC-pouch patients with the NOD2 1007fs variant had elevated ASCA and ALCA levels compared with those without the variant (50% vs 7%, P = 0.004, and 50% vs 8%, P = 0.006, respectively). Importantly, ATG16L1 A300T and NOD2 variants were not associated with serologic responses in healthy controls and unoperated UC patients. Multivariate analysis demonstrated that these genetic variants are the main factors associated with specific antiglycan antibody levels in CD and pouch patients.Genetic variants may have disease-specific phenotypic (serotypic) effects. This implies that genetic risk factors may also be disease modifiers." @default.
• W2893396791 created "2018-10-05" @default.
• W2893396791 creator A5022993615 @default.
• W2893396791 creator A5028811094 @default.
• W2893396791 creator A5029273084 @default.
• W2893396791 creator A5037986981 @default.
• W2893396791 creator A5069738170 @default.
• W2893396791 creator A5074521489 @default.
• W2893396791 creator A5078184286 @default.
• W2893396791 creator A5079900789 @default.
• W2893396791 date "2018-09-27" @default.
• W2893396791 modified "2023-09-24" @default.
• W2893396791 title "Genotype–Serotype Interactions Shed Light on Genetic Components of Inflammatory Bowel Diseases" @default.
• W2893396791 cites W1609503004 @default.
• W2893396791 cites W1642457845 @default.
• W2893396791 cites W1966167200 @default.
• W2893396791 cites W1983901390 @default.
• W2893396791 cites W2005699689 @default.
• W2893396791 cites W2007729377 @default.
• W2893396791 cites W2017443683 @default.
• W2893396791 cites W2021178651 @default.
• W2893396791 cites W2026074634 @default.
• W2893396791 cites W2028875662 @default.
• W2893396791 cites W2031035500 @default.
• W2893396791 cites W2043775908 @default.
• W2893396791 cites W2051766001 @default.
• W2893396791 cites W2101777324 @default.
• W2893396791 cites W2102013054 @default.
• W2893396791 cites W2143625465 @default.
• W2893396791 cites W2149943864 @default.
• W2893396791 cites W2154761473 @default.
• W2893396791 cites W2156050746 @default.
• W2893396791 cites W2256016639 @default.
• W2893396791 cites W2344724546 @default.
• W2893396791 cites W2346233234 @default.
• W2893396791 cites W2489907783 @default.
• W2893396791 cites W2513879826 @default.
• W2893396791 cites W2591843498 @default.
• W2893396791 cites W2725316683 @default.
• W2893396791 doi "https://doi.org/10.1093/ibd/izy231" @default.
• W2893396791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30265311" @default.
• W2893396791 hasPublicationYear "2018" @default.
• W2893396791 type Work @default.
• W2893396791 sameAs 2893396791 @default.
• W2893396791 citedByCount "2" @default.
• W2893396791 countsByYear W28933967912018 @default.
• W2893396791 countsByYear W28933967912022 @default.
• W2893396791 crossrefType "journal-article" @default.
• W2893396791 hasAuthorship W2893396791A5022993615 @default.
• W2893396791 hasAuthorship W2893396791A5028811094 @default.
• W2893396791 hasAuthorship W2893396791A5029273084 @default.
• W2893396791 hasAuthorship W2893396791A5037986981 @default.
• W2893396791 hasAuthorship W2893396791A5069738170 @default.
• W2893396791 hasAuthorship W2893396791A5074521489 @default.
• W2893396791 hasAuthorship W2893396791A5078184286 @default.
• W2893396791 hasAuthorship W2893396791A5079900789 @default.
• W2893396791 hasConcept C104317684 @default.
• W2893396791 hasConcept C12125453 @default.
• W2893396791 hasConcept C126322002 @default.
• W2893396791 hasConcept C127716648 @default.
• W2893396791 hasConcept C135763542 @default.
• W2893396791 hasConcept C153471976 @default.
• W2893396791 hasConcept C159654299 @default.
• W2893396791 hasConcept C187092789 @default.
• W2893396791 hasConcept C203014093 @default.
• W2893396791 hasConcept C2778260677 @default.
• W2893396791 hasConcept C2779134260 @default.
• W2893396791 hasConcept C2779280984 @default.
• W2893396791 hasConcept C2780479503 @default.
• W2893396791 hasConcept C45189115 @default.
• W2893396791 hasConcept C54355233 @default.
• W2893396791 hasConcept C71924100 @default.
• W2893396791 hasConcept C7573103 @default.
• W2893396791 hasConcept C86803240 @default.
• W2893396791 hasConcept C90924648 @default.
• W2893396791 hasConceptScore W2893396791C104317684 @default.
• W2893396791 hasConceptScore W2893396791C12125453 @default.
• W2893396791 hasConceptScore W2893396791C126322002 @default.
• W2893396791 hasConceptScore W2893396791C127716648 @default.
• W2893396791 hasConceptScore W2893396791C135763542 @default.
• W2893396791 hasConceptScore W2893396791C153471976 @default.
• W2893396791 hasConceptScore W2893396791C159654299 @default.
• W2893396791 hasConceptScore W2893396791C187092789 @default.
• W2893396791 hasConceptScore W2893396791C203014093 @default.
• W2893396791 hasConceptScore W2893396791C2778260677 @default.
• W2893396791 hasConceptScore W2893396791C2779134260 @default.
• W2893396791 hasConceptScore W2893396791C2779280984 @default.
• W2893396791 hasConceptScore W2893396791C2780479503 @default.
• W2893396791 hasConceptScore W2893396791C45189115 @default.
• W2893396791 hasConceptScore W2893396791C54355233 @default.
• W2893396791 hasConceptScore W2893396791C71924100 @default.
• W2893396791 hasConceptScore W2893396791C7573103 @default.
• W2893396791 hasConceptScore W2893396791C86803240 @default.
• W2893396791 hasConceptScore W2893396791C90924648 @default.
• W2893396791 hasLocation W28933967911 @default.
• W2893396791 hasLocation W28933967912 @default.
• W2893396791 hasOpenAccess W2893396791 @default.
• W2893396791 hasPrimaryLocation W28933967911 @default.
• W2893396791 hasRelatedWork W2026074634 @default.
• W2893396791 hasRelatedWork W2026682137 @default.

• next