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- W2893401910 abstract "Abstract Melanoma is a leading cause of cancer deaths in the United States. Mutation of valine-to-glutamic acid substitution at position 600 (V600) in the BRAF gene occurs in ~ 75% of melanoma cases. This mutation constitutively activates the mitogen-activated protein kinase (MAPK, originally known as extracellular signal-regulated kinase, ERK) pathway, presenting a therapeutic target amenable to adjunctive or complementary management options. Preclinical/clinical studies of BRAF inhibitors show therapeutic promise, illustrated by the FDA-approved Zelboraf for the treatment of metastatic melanoma harboring the V600E mutation. However, resistance to Zelboraf and other V600E mutation targeting drugs has been observed in some patients. We hypothesize that it is possible to counteract the observed V600E mutation drug resistance using diet-derived polyphenols cotargeting the inhibition of MEK1 (MAPK/ERK activating kinase) and MAPK/ERK. An intervention “cocktail” comprising dietary polyphenols may be suggested for development as “low bioactivity-less resistance inducing” adjunctive treatment of melanoma." @default.
- W2893401910 created "2018-10-05" @default.
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- W2893401910 date "2018-01-01" @default.
- W2893401910 modified "2023-09-24" @default.
- W2893401910 title "Counteracting Resistance to BRAF V600E Mutation in Melanoma Using Dietary Polyphenols" @default.
- W2893401910 doi "https://doi.org/10.1016/b978-0-12-813008-7.00015-1" @default.
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