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• W2893404342 abstract "Abstract The distribution of Asian ancestry in the genome of Danish Duroc pigs was investigated using whole‐genome sequencing data from European wild boars, Danish Duroc, Chinese Meishan and Bamaxiang pigs. Asian haplotypes deriving from Meishan and Bamaxiang occur widely across the genome. Signatures of selection on Asian haplotypes are common in the genome, but few of these haplotypes have been fixed. By defining 50‐kb windows with more than 50% Chinese ancestry, which did not exhibit extreme genetic differentiation between Meishan and Bamaxiang as candidate regions, the enrichment of quantitative trait loci in candidate regions supports that Asian haplotypes under selection play an important role in contributing genetic variation underlying production, reproduction, meat and carcass, and exterior traits. Gene annotation of regions with the highest proportion of Chinese ancestry revealed genes of biological interest, such as NR6A1 . Further haplotype clustering analysis suggested that a haplotype of Chinese origin around the NR6A1 gene was introduced to Europe and then underwent a selective sweep in European pigs. Besides, functional genes in candidate regions, such as AHR and PGRMC2 , associated with fertility, and SAL1 , associated with meat quality, were identified. Our results demonstrate the contribution of Asian haplotypes to the genomes of European pigs. Findings herein facilitate further genomic studies such as genomewide association study and genomic prediction by providing ancestry information of variants." @default.
• W2893404342 created "2018-10-05" @default.
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• W2893404342 date "2018-12-13" @default.
• W2893404342 modified "2023-09-26" @default.
• W2893404342 title "Introgression of Chinese haplotypes contributed to the improvement of Danish Duroc pigs" @default.
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• W2893404342 doi "https://doi.org/10.1111/eva.12716" @default.
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