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- W2893404769 abstract "Previous studies have shown that serum levels of interleukin-6 (IL-6), which plays an important role in the development of systemic inflammatory response syndrome (SIRS), is significantly increased in wasp sting patients. However, the association between IL-6 gene variants and the risk of SIRS development in these patients is not clearly understood. In this study, we investigated the association between IL-6 gene polymorphism in the promoter region and the risk of SIRS in wasp sting patients. A total of 160 patients were divided into SIRS group and non-SIRS group (control), and evaluated for polymorphisms in IL-6 (−174G/C, −572G/C, −597G/A, and −634C/G), using DNA sequencing. The IL-6 serum levels were assessed using an enzyme-linked immunosorbent assay. Risk factors were analyzed by logistic regression analysis. We found that the IL-6 serum level was significantly higher in the SIRS group than in the control group (p < 0.001). A significant association was observed in the genotypic distribution of the IL-6 − 572G allele in the SIRS group, when compared with the control group [OR = 3.909 (1.906–8.019), p < 0.001], and SIRS is more likely to occur in wasp sting patients with more than 10 stings. Thus, the IL-6 − 572G allele and more than 10 stings can be used as predictors of risk of SIRS development in wasp sting patients." @default.
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- W2893404769 date "2018-12-01" @default.
- W2893404769 modified "2023-10-01" @default.
- W2893404769 title "Interleukin-6 Gene Polymorphism and the Risk of Systemic Inflammatory Response Syndrome Caused by Wasp Sting Injury" @default.
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- W2893404769 doi "https://doi.org/10.1089/dna.2018.4156" @default.
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