FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893420719> ?p ?o ?g. }

• W2893420719 endingPage "6426" @default.
• W2893420719 startingPage "6417" @default.
• W2893420719 abstract "Oxidative stress during sepsis pathogenesis remains the most-important factor creating imbalance and dysregulation in immune-cell function, usually observed following initial infection. Hydrogen peroxide (H2O2), a potentially toxic reactive oxygen species (ROS), is excessively produced by pro-inflammatory immune cells during the initial phases of sepsis and plays a dominant role in regulating the pathways associated with systemic inflammatory immune activation. In the present study, we constructed a peroxide scavenger mannosylated polymeric albumin manganese dioxide (mSPAM) nanoassembly to catalyze the decomposition of H2O2 responsible for the hyper-activation of pro-inflammatory immune cells. In a detailed manner, we investigated the role of mSPAM nanoassembly in modulating the expression and secretion of pro-inflammatory markers elevated in bacterial lipopolysaccharide (LPS)-mediated endotoxemia during sepsis. Through a facile one-step solution-phase approach, hydrophilic bovine serum albumin reduced manganese dioxide (BM) nanoparticles were synthesized and subsequently self-assembled with cationic mannosylated disulfide cross-linked polyethylenimine (mSP) to formulate mSPAM nanoassembly. In particular, we observed that the highly stable mSPAM nanoassembly suppressed HIF1α expression by scavenging H2O2 in LPS-induced macrophage cells. Initial investigation revealed that a significant reduction of free radicals by the treatment of mSPAM nanoassembly has reduced the infiltration of neutrophils and other leukocytes in a local endotoxemia animal model. Furthermore, therapeutic studies in a systemic endotoxemia model demonstrated that mSPAM treatment reduced TNF-α and IL-6 inflammatory cytokines in serum, in turn circumventing organ damage done by the inflammatory macrophages. Interestingly, we also observed that the reduction of these inflammatory cytokines by mSPAM nanoassembly further prevented IBA-1 immuno-positive microglial cell activation in the brain and consequently improved the cognitive function of the animals. Altogether, the administration of mSPAM nanoassembly scavenged H2O2 and suppressed HIF1α expression in LPS-stimulated macrophages and thereby inhibited the progression of local and systemic inflammation as well as neuroinflammation in an LPS-induced endotoxemia model. This mSPAM nanoassembly system could serve as a potent anti-inflammatory agent, and we further anticipate its successful application in treating various inflammation-related diseases." @default.
• W2893420719 created "2018-10-05" @default.
• W2893420719 creator A5003255210 @default.
• W2893420719 creator A5004374498 @default.
• W2893420719 creator A5022464721 @default.
• W2893420719 creator A5026361494 @default.
• W2893420719 creator A5042775709 @default.
• W2893420719 creator A5045010999 @default.
• W2893420719 creator A5053995401 @default.
• W2893420719 creator A5067595080 @default.
• W2893420719 creator A5089431903 @default.
• W2893420719 date "2018-09-24" @default.
• W2893420719 modified "2023-10-17" @default.
• W2893420719 title "Peroxidase-Mimicking Nanoassembly Mitigates Lipopolysaccharide-Induced Endotoxemia and Cognitive Damage in the Brain by Impeding Inflammatory Signaling in Macrophages" @default.
• W2893420719 cites W1506926045 @default.
• W2893420719 cites W1563590122 @default.
• W2893420719 cites W1587781546 @default.
• W2893420719 cites W1808203102 @default.
• W2893420719 cites W1906027219 @default.
• W2893420719 cites W1929089343 @default.
• W2893420719 cites W1954286166 @default.
• W2893420719 cites W1966622630 @default.
• W2893420719 cites W1970621826 @default.
• W2893420719 cites W1971403257 @default.
• W2893420719 cites W1973855919 @default.
• W2893420719 cites W1978371146 @default.
• W2893420719 cites W1978718459 @default.
• W2893420719 cites W1982381743 @default.
• W2893420719 cites W1985126638 @default.
• W2893420719 cites W1986725397 @default.
• W2893420719 cites W1986791525 @default.
• W2893420719 cites W1988049652 @default.
• W2893420719 cites W1989704413 @default.
• W2893420719 cites W1994720283 @default.
• W2893420719 cites W1996686306 @default.
• W2893420719 cites W2006317863 @default.
• W2893420719 cites W2030635984 @default.
• W2893420719 cites W2031222511 @default.
• W2893420719 cites W2035440890 @default.
• W2893420719 cites W2038636572 @default.
• W2893420719 cites W2039190334 @default.
• W2893420719 cites W2047247630 @default.
• W2893420719 cites W2050994594 @default.
• W2893420719 cites W2053554593 @default.
• W2893420719 cites W2053568531 @default.
• W2893420719 cites W2057644703 @default.
• W2893420719 cites W2061434349 @default.
• W2893420719 cites W2065961872 @default.
• W2893420719 cites W2066037960 @default.
• W2893420719 cites W2068631906 @default.
• W2893420719 cites W2072198924 @default.
• W2893420719 cites W2073066847 @default.
• W2893420719 cites W2084564904 @default.
• W2893420719 cites W2091128689 @default.
• W2893420719 cites W2091164627 @default.
• W2893420719 cites W2091581243 @default.
• W2893420719 cites W2092787008 @default.
• W2893420719 cites W2101728241 @default.
• W2893420719 cites W2106925175 @default.
• W2893420719 cites W2117437970 @default.
• W2893420719 cites W2117780076 @default.
• W2893420719 cites W2117796628 @default.
• W2893420719 cites W2119275519 @default.
• W2893420719 cites W2128760071 @default.
• W2893420719 cites W2135388629 @default.
• W2893420719 cites W2138635268 @default.
• W2893420719 cites W2151821796 @default.
• W2893420719 cites W2153586956 @default.
• W2893420719 cites W2154728076 @default.
• W2893420719 cites W2156514608 @default.
• W2893420719 cites W2172260616 @default.
• W2893420719 cites W2173456973 @default.
• W2893420719 cites W2218838944 @default.
• W2893420719 cites W2312991224 @default.
• W2893420719 cites W2334745021 @default.
• W2893420719 cites W2397507181 @default.
• W2893420719 cites W2413193118 @default.
• W2893420719 cites W2465739385 @default.
• W2893420719 cites W2466924377 @default.
• W2893420719 cites W2492237861 @default.
• W2893420719 cites W2519685466 @default.
• W2893420719 cites W2520620275 @default.
• W2893420719 cites W2524394696 @default.
• W2893420719 cites W2528843175 @default.
• W2893420719 cites W2548971866 @default.
• W2893420719 cites W2606156871 @default.
• W2893420719 cites W2747744817 @default.
• W2893420719 cites W2776503439 @default.
• W2893420719 cites W2785433682 @default.
• W2893420719 cites W4232045654 @default.
• W2893420719 cites W852335522 @default.
• W2893420719 doi "https://doi.org/10.1021/acs.nanolett.8b02785" @default.
• W2893420719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247915" @default.
• W2893420719 hasPublicationYear "2018" @default.
• W2893420719 type Work @default.
• W2893420719 sameAs 2893420719 @default.
• W2893420719 citedByCount "53" @default.
• W2893420719 countsByYear W28934207192018 @default.

• next