Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893431925> ?p ?o ?g. }
- W2893431925 endingPage "44" @default.
- W2893431925 startingPage "37" @default.
- W2893431925 abstract "Devil's claw is used for the treatment of inflammatory symptoms and degenerative disorders in horses since many years, but without the substantive pharmacokinetic data. The pharmacokinetic parameters of harpagoside, the main active constituent of Harpagophytum procumbens DC ex Meisn., were evaluated in equine plasma after administration of Harpagophytum extract FB 8858 in an open, single-dose, two-treatment, two-period, randomized cross-over design. Six horses received a single dose of Harpagophytum extract, corresponding to 5 mg/kg BM harpagoside, and after 7 days washout period, 10 mg/kg BM harpagoside via nasogastric tube. Plasma samples at certain time points (before and 0–24 hr after administration) were collected, cleaned up by solid-phase extraction, and harpagoside concentrations were determined by LC-MS/MS using apigenin-7-glucoside as internal standard. Plasma concentration-time data and relevant parameters were described by noncompartmental model through PKSolver software. Harpagoside could be detected up to 9 hr after administration. Cmax was found at 25.59 and 55.46 ng/ml, t1/2 at 2.53 and 2.32 hr, respectively, and tmax at 1 hr in both trials. AUC0–inf was 70.46 and 117.85 ng hr ml−1, respectively. A proportional relationship between dose, Cmax and AUC was observed. Distribution (Vz/F) was 259.04 and 283.83 L/kg and clearance (CL/F) 70.96 and 84.86 L hr−1 kg−1, respectively. Treatment of horses with Harpagophytum extract did not cause any clinically detectable side effects." @default.
- W2893431925 created "2018-10-05" @default.
- W2893431925 creator A5010997059 @default.
- W2893431925 creator A5021246167 @default.
- W2893431925 creator A5057527406 @default.
- W2893431925 creator A5069969354 @default.
- W2893431925 creator A5084372347 @default.
- W2893431925 date "2018-09-22" @default.
- W2893431925 modified "2023-09-26" @default.
- W2893431925 title "Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw<i>(Harpagophytum procumbens)</i>extract" @default.
- W2893431925 cites W121907455 @default.
- W2893431925 cites W1484127798 @default.
- W2893431925 cites W1963842040 @default.
- W2893431925 cites W1971523098 @default.
- W2893431925 cites W1971607807 @default.
- W2893431925 cites W1971790908 @default.
- W2893431925 cites W1981346855 @default.
- W2893431925 cites W1988339230 @default.
- W2893431925 cites W1993647565 @default.
- W2893431925 cites W2008647446 @default.
- W2893431925 cites W2011970638 @default.
- W2893431925 cites W2013515410 @default.
- W2893431925 cites W2016664583 @default.
- W2893431925 cites W2017518004 @default.
- W2893431925 cites W2034313213 @default.
- W2893431925 cites W2048419162 @default.
- W2893431925 cites W2050959281 @default.
- W2893431925 cites W2052661559 @default.
- W2893431925 cites W2058423662 @default.
- W2893431925 cites W2063909696 @default.
- W2893431925 cites W2068743068 @default.
- W2893431925 cites W2082798004 @default.
- W2893431925 cites W2094175281 @default.
- W2893431925 cites W2109108975 @default.
- W2893431925 cites W2115704903 @default.
- W2893431925 cites W2122982754 @default.
- W2893431925 cites W2124382534 @default.
- W2893431925 cites W2141058448 @default.
- W2893431925 cites W2150896970 @default.
- W2893431925 cites W2157939981 @default.
- W2893431925 cites W2165711931 @default.
- W2893431925 cites W2170136728 @default.
- W2893431925 cites W2297137911 @default.
- W2893431925 cites W2318031785 @default.
- W2893431925 cites W2333810590 @default.
- W2893431925 cites W2893431925 @default.
- W2893431925 cites W3559567 @default.
- W2893431925 cites W61017513 @default.
- W2893431925 doi "https://doi.org/10.1111/jvp.12716" @default.
- W2893431925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379497" @default.
- W2893431925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242850" @default.
- W2893431925 hasPublicationYear "2018" @default.
- W2893431925 type Work @default.
- W2893431925 sameAs 2893431925 @default.
- W2893431925 citedByCount "12" @default.
- W2893431925 countsByYear W28934319252018 @default.
- W2893431925 countsByYear W28934319252020 @default.
- W2893431925 countsByYear W28934319252021 @default.
- W2893431925 countsByYear W28934319252022 @default.
- W2893431925 crossrefType "journal-article" @default.
- W2893431925 hasAuthorship W2893431925A5010997059 @default.
- W2893431925 hasAuthorship W2893431925A5021246167 @default.
- W2893431925 hasAuthorship W2893431925A5057527406 @default.
- W2893431925 hasAuthorship W2893431925A5069969354 @default.
- W2893431925 hasAuthorship W2893431925A5084372347 @default.
- W2893431925 hasBestOaLocation W28934319251 @default.
- W2893431925 hasConcept C112705442 @default.
- W2893431925 hasConcept C22979827 @default.
- W2893431925 hasConcept C2777056448 @default.
- W2893431925 hasConcept C556039675 @default.
- W2893431925 hasConcept C71924100 @default.
- W2893431925 hasConcept C98274493 @default.
- W2893431925 hasConceptScore W2893431925C112705442 @default.
- W2893431925 hasConceptScore W2893431925C22979827 @default.
- W2893431925 hasConceptScore W2893431925C2777056448 @default.
- W2893431925 hasConceptScore W2893431925C556039675 @default.
- W2893431925 hasConceptScore W2893431925C71924100 @default.
- W2893431925 hasConceptScore W2893431925C98274493 @default.
- W2893431925 hasIssue "1" @default.
- W2893431925 hasLocation W28934319251 @default.
- W2893431925 hasLocation W28934319252 @default.
- W2893431925 hasLocation W28934319253 @default.
- W2893431925 hasLocation W28934319254 @default.
- W2893431925 hasOpenAccess W2893431925 @default.
- W2893431925 hasPrimaryLocation W28934319251 @default.
- W2893431925 hasRelatedWork W1566015146 @default.
- W2893431925 hasRelatedWork W1982777678 @default.
- W2893431925 hasRelatedWork W2053092589 @default.
- W2893431925 hasRelatedWork W2056938528 @default.
- W2893431925 hasRelatedWork W2057097799 @default.
- W2893431925 hasRelatedWork W2081338779 @default.
- W2893431925 hasRelatedWork W2374464808 @default.
- W2893431925 hasRelatedWork W2766550598 @default.
- W2893431925 hasRelatedWork W4224326956 @default.
- W2893431925 hasRelatedWork W4238545538 @default.
- W2893431925 hasVolume "42" @default.
- W2893431925 isParatext "false" @default.
- W2893431925 isRetracted "false" @default.