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• W2893433827 abstract "Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response (UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum (ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP." @default.
• W2893433827 created "2018-10-05" @default.
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• W2893433827 date "2018-09-29" @default.
• W2893433827 modified "2023-10-16" @default.
• W2893433827 title "Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis" @default.
• W2893433827 cites W1964190813 @default.
• W2893433827 cites W1964631254 @default.
• W2893433827 cites W1966157599 @default.
• W2893433827 cites W1970090817 @default.
• W2893433827 cites W1972516036 @default.
• W2893433827 cites W1977603207 @default.
• W2893433827 cites W1978390469 @default.
• W2893433827 cites W1982491871 @default.
• W2893433827 cites W1986737010 @default.
• W2893433827 cites W1990607211 @default.
• W2893433827 cites W1994239968 @default.
• W2893433827 cites W1997718215 @default.
• W2893433827 cites W1998284079 @default.
• W2893433827 cites W2001712980 @default.
• W2893433827 cites W2002439304 @default.
• W2893433827 cites W2007078899 @default.
• W2893433827 cites W2010375635 @default.
• W2893433827 cites W2010984496 @default.
• W2893433827 cites W2019236383 @default.
• W2893433827 cites W2020437934 @default.
• W2893433827 cites W2026238321 @default.
• W2893433827 cites W2026293353 @default.
• W2893433827 cites W2027888296 @default.
• W2893433827 cites W2033548191 @default.
• W2893433827 cites W2033754437 @default.
• W2893433827 cites W2037397212 @default.
• W2893433827 cites W2042487525 @default.
• W2893433827 cites W2045276152 @default.
• W2893433827 cites W2046076623 @default.
• W2893433827 cites W2048098925 @default.
• W2893433827 cites W2053500970 @default.
• W2893433827 cites W2056129497 @default.
• W2893433827 cites W2059930201 @default.
• W2893433827 cites W2060082095 @default.
• W2893433827 cites W2062167356 @default.
• W2893433827 cites W2066538173 @default.
• W2893433827 cites W2069366124 @default.
• W2893433827 cites W2070949249 @default.
• W2893433827 cites W2075266492 @default.
• W2893433827 cites W2076880493 @default.
• W2893433827 cites W2089198803 @default.
• W2893433827 cites W2100034830 @default.
• W2893433827 cites W2100175873 @default.
• W2893433827 cites W2103795148 @default.
• W2893433827 cites W2104869288 @default.
• W2893433827 cites W2109057101 @default.
• W2893433827 cites W2117378242 @default.
• W2893433827 cites W2117445500 @default.
• W2893433827 cites W2120736516 @default.
• W2893433827 cites W2120794334 @default.
• W2893433827 cites W2121857344 @default.
• W2893433827 cites W2122023122 @default.
• W2893433827 cites W2124545837 @default.
• W2893433827 cites W2127639686 @default.
• W2893433827 cites W2127848114 @default.
• W2893433827 cites W2128852331 @default.
• W2893433827 cites W2132376585 @default.
• W2893433827 cites W2139568257 @default.
• W2893433827 cites W2144065739 @default.
• W2893433827 cites W2147950253 @default.
• W2893433827 cites W2148429443 @default.
• W2893433827 cites W2149927906 @default.
• W2893433827 cites W2152477540 @default.
• W2893433827 cites W2154043031 @default.
• W2893433827 cites W2158837517 @default.
• W2893433827 cites W2169172001 @default.
• W2893433827 cites W2170161312 @default.
• W2893433827 cites W2192080449 @default.
• W2893433827 cites W2219849966 @default.
• W2893433827 cites W2233779849 @default.
• W2893433827 cites W2316926039 @default.
• W2893433827 cites W2334966793 @default.
• W2893433827 cites W2397797544 @default.
• W2893433827 cites W2495647715 @default.
• W2893433827 cites W2519763123 @default.
• W2893433827 cites W2564335242 @default.
• W2893433827 cites W2606002120 @default.
• W2893433827 cites W2614360956 @default.
• W2893433827 cites W2746453523 @default.
• W2893433827 cites W4232479519 @default.
• W2893433827 cites W625755886 @default.
• W2893433827 doi "https://doi.org/10.4291/wjgp.v9.i2.37" @default.
• W2893433827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163129" @default.

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