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- W2893434308 endingPage "113" @default.
- W2893434308 startingPage "103" @default.
- W2893434308 abstract "CRISPR-based genome editing provides a simple and scalable toolbox for a variety of therapeutic and biotechnology applications. Whilst the fundamental properties of CRISPR proved easily transferable from the native prokaryotic hosts to eukaryotic and multicellular organisms, the tight control of the CRISPR-editing activity remains a major challenge. Here we summarise recent developments of CRISPR and riboswitch technologies and recommend novel functionalised synthetic-gRNA (sgRNA) designs to achieve inducible and spatiotemporal regulation of CRISPR-based genetic editors in response to cellular or extracellular stimuli. We believe that future advances of these tools will have major implications for both basic and applied research, spanning from fundamental genetic studies and synthetic biology to genetic editing and gene therapy." @default.
- W2893434308 created "2018-10-05" @default.
- W2893434308 creator A5011426485 @default.
- W2893434308 creator A5040063355 @default.
- W2893434308 date "2019-02-01" @default.
- W2893434308 modified "2023-09-25" @default.
- W2893434308 title "Engineering CRISPR guide RNA riboswitches for in vivo applications" @default.
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