Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893434697> ?p ?o ?g. }
- W2893434697 abstract "Abstract Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, sphaerocyclamide (1), from Sphaerospermopsis sp. LEGE 00249. The sphaerocyclamide biosynthetic gene cluster ( sph ) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the sph gene cluster in Escherichia coli confirmed the connection between genomic and mass spectrometric data. Unambiguous establishment of the orientation and site of prenylation required the full structural elucidation of 1 using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound 1 was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium Halomonas aquamarina CECT 5000." @default.
- W2893434697 created "2018-10-05" @default.
- W2893434697 creator A5014748749 @default.
- W2893434697 creator A5030741302 @default.
- W2893434697 creator A5038347874 @default.
- W2893434697 creator A5040188531 @default.
- W2893434697 creator A5047370358 @default.
- W2893434697 creator A5051018229 @default.
- W2893434697 creator A5060421147 @default.
- W2893434697 creator A5073326436 @default.
- W2893434697 creator A5077978029 @default.
- W2893434697 creator A5080502201 @default.
- W2893434697 date "2018-09-28" @default.
- W2893434697 modified "2023-10-14" @default.
- W2893434697 title "Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249" @default.
- W2893434697 cites W1510374987 @default.
- W2893434697 cites W1880092145 @default.
- W2893434697 cites W1969209088 @default.
- W2893434697 cites W1970544402 @default.
- W2893434697 cites W1982478404 @default.
- W2893434697 cites W1986383280 @default.
- W2893434697 cites W2011180202 @default.
- W2893434697 cites W2013290234 @default.
- W2893434697 cites W2014206973 @default.
- W2893434697 cites W2023018411 @default.
- W2893434697 cites W2038382683 @default.
- W2893434697 cites W2046357268 @default.
- W2893434697 cites W2048340027 @default.
- W2893434697 cites W2054422679 @default.
- W2893434697 cites W2062688367 @default.
- W2893434697 cites W2067694870 @default.
- W2893434697 cites W2068447382 @default.
- W2893434697 cites W2070946088 @default.
- W2893434697 cites W2075555781 @default.
- W2893434697 cites W2083819749 @default.
- W2893434697 cites W2085960153 @default.
- W2893434697 cites W2092343226 @default.
- W2893434697 cites W2101002869 @default.
- W2893434697 cites W2140693043 @default.
- W2893434697 cites W2152277487 @default.
- W2893434697 cites W2162481919 @default.
- W2893434697 cites W2162854463 @default.
- W2893434697 cites W2166315523 @default.
- W2893434697 cites W2261078516 @default.
- W2893434697 cites W2588984067 @default.
- W2893434697 cites W38288991 @default.
- W2893434697 cites W64548748 @default.
- W2893434697 doi "https://doi.org/10.1038/s41598-018-32618-5" @default.
- W2893434697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162287" @default.
- W2893434697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266955" @default.
- W2893434697 hasPublicationYear "2018" @default.
- W2893434697 type Work @default.
- W2893434697 sameAs 2893434697 @default.
- W2893434697 citedByCount "23" @default.
- W2893434697 countsByYear W28934346972018 @default.
- W2893434697 countsByYear W28934346972019 @default.
- W2893434697 countsByYear W28934346972020 @default.
- W2893434697 countsByYear W28934346972021 @default.
- W2893434697 countsByYear W28934346972022 @default.
- W2893434697 countsByYear W28934346972023 @default.
- W2893434697 crossrefType "journal-article" @default.
- W2893434697 hasAuthorship W2893434697A5014748749 @default.
- W2893434697 hasAuthorship W2893434697A5030741302 @default.
- W2893434697 hasAuthorship W2893434697A5038347874 @default.
- W2893434697 hasAuthorship W2893434697A5040188531 @default.
- W2893434697 hasAuthorship W2893434697A5047370358 @default.
- W2893434697 hasAuthorship W2893434697A5051018229 @default.
- W2893434697 hasAuthorship W2893434697A5060421147 @default.
- W2893434697 hasAuthorship W2893434697A5073326436 @default.
- W2893434697 hasAuthorship W2893434697A5077978029 @default.
- W2893434697 hasAuthorship W2893434697A5080502201 @default.
- W2893434697 hasBestOaLocation W28934346971 @default.
- W2893434697 hasConcept C104317684 @default.
- W2893434697 hasConcept C108305142 @default.
- W2893434697 hasConcept C181199279 @default.
- W2893434697 hasConcept C185592680 @default.
- W2893434697 hasConcept C36857842 @default.
- W2893434697 hasConcept C40767141 @default.
- W2893434697 hasConcept C547475151 @default.
- W2893434697 hasConcept C55493867 @default.
- W2893434697 hasConcept C57790582 @default.
- W2893434697 hasConcept C70721500 @default.
- W2893434697 hasConcept C71240020 @default.
- W2893434697 hasConcept C74187038 @default.
- W2893434697 hasConcept C86803240 @default.
- W2893434697 hasConceptScore W2893434697C104317684 @default.
- W2893434697 hasConceptScore W2893434697C108305142 @default.
- W2893434697 hasConceptScore W2893434697C181199279 @default.
- W2893434697 hasConceptScore W2893434697C185592680 @default.
- W2893434697 hasConceptScore W2893434697C36857842 @default.
- W2893434697 hasConceptScore W2893434697C40767141 @default.
- W2893434697 hasConceptScore W2893434697C547475151 @default.
- W2893434697 hasConceptScore W2893434697C55493867 @default.
- W2893434697 hasConceptScore W2893434697C57790582 @default.
- W2893434697 hasConceptScore W2893434697C70721500 @default.
- W2893434697 hasConceptScore W2893434697C71240020 @default.
- W2893434697 hasConceptScore W2893434697C74187038 @default.
- W2893434697 hasConceptScore W2893434697C86803240 @default.
- W2893434697 hasIssue "1" @default.
- W2893434697 hasLocation W28934346971 @default.