Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893436135> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2893436135 abstract "Dipeptidyl peptidase-4 (DPP4 or CD26)–mediated post-translational modification of chemokines has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional CXCL10. In extending these initial findings to humans and pre-clinical hepatocellular carcinoma models, we discovered a new mechanism whereby DPP4 inhibition improves anti-tumor responses by eosinophil recruitment. Specifically, administration of DPP4 inhibitors (DPP4i) resulted in higher concentrations of CCL11 (or eotaxin) and increased CCR3-mediated eosinophil migration into mouse tumors. Enhanced tumor control was observed upon treatment with DPP4i, an effect strikingly preserved in Rag2–/– mice, and abrogated only upon depletion of eosinophils or inhibition of their degranulation. We further demonstrated that tumor expression of IL-33 was necessary and sufficient for eosinophil-mediated anti-tumor responses, and that this mechanism contributed to checkpoint inhibitor efficacy. These findings provide new insight into IL-33- and eosinophil-mediated tumor control, revealed when endogenous mechanisms of DPP4 immune regulation are inhibited." @default.
- W2893436135 created "2018-10-05" @default.
- W2893436135 creator A5040666856 @default.
- W2893436135 date "2017-09-29" @default.
- W2893436135 modified "2023-09-25" @default.
- W2893436135 title "Role of dipeptidyl peptidase-4 in the regulation of leucocyte trafficking in hepatocellular carcinoma" @default.
- W2893436135 hasPublicationYear "2017" @default.
- W2893436135 type Work @default.
- W2893436135 sameAs 2893436135 @default.
- W2893436135 citedByCount "0" @default.
- W2893436135 crossrefType "dissertation" @default.
- W2893436135 hasAuthorship W2893436135A5040666856 @default.
- W2893436135 hasConcept C126322002 @default.
- W2893436135 hasConcept C13373296 @default.
- W2893436135 hasConcept C134018914 @default.
- W2893436135 hasConcept C156490143 @default.
- W2893436135 hasConcept C170493617 @default.
- W2893436135 hasConcept C181199279 @default.
- W2893436135 hasConcept C203014093 @default.
- W2893436135 hasConcept C2776042228 @default.
- W2893436135 hasConcept C2777037409 @default.
- W2893436135 hasConcept C2777180221 @default.
- W2893436135 hasConcept C2777716647 @default.
- W2893436135 hasConcept C2780590879 @default.
- W2893436135 hasConcept C2781469919 @default.
- W2893436135 hasConcept C49802076 @default.
- W2893436135 hasConcept C502942594 @default.
- W2893436135 hasConcept C55493867 @default.
- W2893436135 hasConcept C555293320 @default.
- W2893436135 hasConcept C5858377 @default.
- W2893436135 hasConcept C71924100 @default.
- W2893436135 hasConcept C86803240 @default.
- W2893436135 hasConcept C8891405 @default.
- W2893436135 hasConceptScore W2893436135C126322002 @default.
- W2893436135 hasConceptScore W2893436135C13373296 @default.
- W2893436135 hasConceptScore W2893436135C134018914 @default.
- W2893436135 hasConceptScore W2893436135C156490143 @default.
- W2893436135 hasConceptScore W2893436135C170493617 @default.
- W2893436135 hasConceptScore W2893436135C181199279 @default.
- W2893436135 hasConceptScore W2893436135C203014093 @default.
- W2893436135 hasConceptScore W2893436135C2776042228 @default.
- W2893436135 hasConceptScore W2893436135C2777037409 @default.
- W2893436135 hasConceptScore W2893436135C2777180221 @default.
- W2893436135 hasConceptScore W2893436135C2777716647 @default.
- W2893436135 hasConceptScore W2893436135C2780590879 @default.
- W2893436135 hasConceptScore W2893436135C2781469919 @default.
- W2893436135 hasConceptScore W2893436135C49802076 @default.
- W2893436135 hasConceptScore W2893436135C502942594 @default.
- W2893436135 hasConceptScore W2893436135C55493867 @default.
- W2893436135 hasConceptScore W2893436135C555293320 @default.
- W2893436135 hasConceptScore W2893436135C5858377 @default.
- W2893436135 hasConceptScore W2893436135C71924100 @default.
- W2893436135 hasConceptScore W2893436135C86803240 @default.
- W2893436135 hasConceptScore W2893436135C8891405 @default.
- W2893436135 hasLocation W28934361351 @default.
- W2893436135 hasOpenAccess W2893436135 @default.
- W2893436135 hasPrimaryLocation W28934361351 @default.
- W2893436135 hasRelatedWork W1480011037 @default.
- W2893436135 hasRelatedWork W2000155645 @default.
- W2893436135 hasRelatedWork W2085019148 @default.
- W2893436135 hasRelatedWork W2116898765 @default.
- W2893436135 hasRelatedWork W2135684427 @default.
- W2893436135 hasRelatedWork W2157309751 @default.
- W2893436135 hasRelatedWork W2176501069 @default.
- W2893436135 hasRelatedWork W2505814494 @default.
- W2893436135 hasRelatedWork W2548551967 @default.
- W2893436135 hasRelatedWork W2558963636 @default.
- W2893436135 hasRelatedWork W2575659288 @default.
- W2893436135 hasRelatedWork W2765213457 @default.
- W2893436135 hasRelatedWork W2889965257 @default.
- W2893436135 hasRelatedWork W2906161186 @default.
- W2893436135 hasRelatedWork W2912735280 @default.
- W2893436135 hasRelatedWork W2938119062 @default.
- W2893436135 hasRelatedWork W2968437728 @default.
- W2893436135 hasRelatedWork W2973050087 @default.
- W2893436135 hasRelatedWork W3081980149 @default.
- W2893436135 hasRelatedWork W2902003593 @default.
- W2893436135 isParatext "false" @default.
- W2893436135 isRetracted "false" @default.
- W2893436135 magId "2893436135" @default.
- W2893436135 workType "dissertation" @default.