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• W2893436513 abstract "The primary function of the pharyngeal swallowing mechanism is to drive ingested materials into the esophagus. Currently, a definitive measure of pharyngeal bolus-driving function that accounts for bolus movement remains lacking. The primary objectives of this study were to describe the derivation of a novel biofluid dynamics measure of deglutition-that is, pharyngeal swallowing power (PSP)-and to demonstrate the consistency of PSP in normal swallowing.The pharyngeal swallowing mechanism was conceptualized as a hydraulic power system with the upper esophageal sphincter (UES) as a conduit. PSP was calculated as the product of bolus pressure and flow across the UES. Thirty-four young healthy subjects swallowed materials consisting of two bolus volumes (10, 20 mL) and four bolus viscosities (thin liquid, nectar-thick liquid, honey-thick liquid, pudding). High-resolution impedance manometry was used for data collection. The consistency of PSP across specific bolus conditions was evaluated using standardized Cronbach's coefficient alpha.Standardized Cronbach's coefficient alphas in specific bolus conditions ranged between 0.85 and 0.93. Fisher weighted mean Cronbach's coefficient alphas for swallow trials across bolus volumes and across bolus viscosities ranged from 0.86 to 0.90. Fisher weighted mean Cronbach's coefficient alpha for overall consistency of PSP across all swallow trials was 0.88.PSP estimates the output power of the pharyngeal bolus-driving mechanism during deglutition. PSP's high consistency indicates that it can be a useful biofluid dynamics measure of pharyngeal bolus-driving function. Current results also demonstrate that consistency in pharyngeal bolus propulsion is an important physiological target for the pharyngeal swallowing mechanism." @default.
• W2893436513 created "2018-10-05" @default.
• W2893436513 creator A5025004880 @default.
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• W2893436513 date "2018-09-23" @default.
• W2893436513 modified "2023-09-24" @default.
• W2893436513 title "Derivation and measurement consistency of a novel biofluid dynamics measure of deglutitive bolus‐driving function—pharyngeal swallowing power" @default.
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• W2893436513 doi "https://doi.org/10.1111/nmo.13465" @default.
• W2893436513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6296874" @default.
• W2893436513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30246422" @default.
• W2893436513 hasPublicationYear "2018" @default.
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