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- W2893465213 abstract "For the first time, endogenous amounts of Leu-enkephalin are measured in brain tissue with a technique preserving integrity of the entire molecular structure of the neuropeptide. Field-desorption mass spectrometry enables measurement of picomole amounts of endogenous, chemically underivatized Leu-enkephalin in canine caudate nuclei and hypothalami. The optimal sensitivity and resolution of high-performance liquid chromatography is coupled with maximal molecular specificity of field-desorption mass spectrometry to measure enkephalins in caudate nuclei and hypothalami from dog brains. This novel combination of two recent instrumental methodologies provides a firm molecular basis for calibrating the radioimmunoassay measurement of endogenous levels of biologically active brain neuropeptides." @default.
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- W2893465213 date "1983-01-01" @default.
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- W2893465213 title "Measurement of Endogenous Leucine Enkephalin in Canine Caudate Nuclei and Hypothalami with High-Performance Liquid Chromatography and Field-Desorption Mass Spectrometry11This paper was presented at the International Symposium on HPLC of Proteins and Peptides, November 16–17, 1981, Washington, D. C." @default.
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