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- W2893467144 abstract "Aim: We created rat models of osteoporosis and verified a novel idea to recover bone mass via local cell transplantation. Materials & methods: The rats were treated with ovariectomy, 0.1% calcium diet or 3 mg/kg body weight/day of prednisolone and porcine-induced pluripotent stem cell (piPSC)-derived osteoblast-like cells were transplanted into the medullary cavity of the left femurs. Results: The piPSC-derived osteoblast-like cells exerted therapeutic potential on prednisolone treatment group, which confirmed by improvements in trabecular bone volume (15.93 ± 2.20%), bone surface/volume ratio (27.82 ± 1.40 1/mm), thickness (1.40 ± 0.01 mm), separation (0.99 ± 0.10 mm), number (1.13 ± 0.13 1/mm) and total porosity (84.06 ± 2.20%). Conclusion: These results first uncovered therapeutic potential of xenotransplantation with piPSCs for glucocorticoid-induced osteoporosis treatment in the rat models." @default.
- W2893467144 created "2018-10-05" @default.
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- W2893467144 date "2018-09-01" @default.
- W2893467144 modified "2023-10-05" @default.
- W2893467144 title "Porcine-induced pluripotent stem cell-derived osteoblast-like cells ameliorate trabecular bone mass of osteoporotic rats" @default.
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- W2893467144 doi "https://doi.org/10.2217/rme-2018-0014" @default.
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