FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893478136> ?p ?o ?g. }

• W2893478136 abstract "Abstract Early evidence indicates that the long non-coding RNA CCAL plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of CCAL in gastric tumourigenesis and progression remain largely unknown. We observed that CCAL was upregulated in gastric cancer tissues and was associated with the tumour-node-metastasis stage. Functional experiments showed that CCAL promoted gastric cancer cell proliferation and metastasis in vitro and in vivo. Luciferase reporter assay indicated that CCAL directly bind to miR-149. Moreover, knockdown of CCAL significantly reduced the expression of FOXM1, a direct target of miR-149. We also showed that FOXM1 suppression by miR-149 could be partially rescued by CCAL overexpression. In addition, we identified a negative correlation between the mRNA expression of CCAL and miR-149 in gastric cancer tissues. Furthermore, we observed a negative correlation between the expression of miR-149 and FOXM1 and a positive correlation between CCAL and FOXM1 levels. These results demonstrated that the CCAL/miR-149/FOXM1 axis functions as a key regulator in gastric cancer metastasis and CCAL potentially represents a biomarker for diagnosis and potential target for therapy in the future." @default.
• W2893478136 created "2018-10-05" @default.
• W2893478136 creator A5009353842 @default.
• W2893478136 creator A5020497057 @default.
• W2893478136 creator A5028895704 @default.
• W2893478136 creator A5029409399 @default.
• W2893478136 creator A5035553951 @default.
• W2893478136 creator A5057453932 @default.
• W2893478136 creator A5087777979 @default.
• W2893478136 date "2018-09-24" @default.
• W2893478136 modified "2023-10-17" @default.
• W2893478136 title "Long non-coding RNA CCAL/miR-149/FOXM1 axis promotes metastasis in gastric cancer" @default.
• W2893478136 cites W1944995278 @default.
• W2893478136 cites W1978047321 @default.
• W2893478136 cites W2000190195 @default.
• W2893478136 cites W2026136425 @default.
• W2893478136 cites W2037471476 @default.
• W2893478136 cites W2049397238 @default.
• W2893478136 cites W2064427521 @default.
• W2893478136 cites W2083507043 @default.
• W2893478136 cites W2091161969 @default.
• W2893478136 cites W2101235585 @default.
• W2893478136 cites W2106787323 @default.
• W2893478136 cites W2109254024 @default.
• W2893478136 cites W2116672660 @default.
• W2893478136 cites W2132611552 @default.
• W2893478136 cites W2144162491 @default.
• W2893478136 cites W2154623878 @default.
• W2893478136 cites W2158089750 @default.
• W2893478136 cites W2263259748 @default.
• W2893478136 cites W2346098055 @default.
• W2893478136 cites W2408937406 @default.
• W2893478136 cites W2489549421 @default.
• W2893478136 cites W2519556212 @default.
• W2893478136 cites W2532643640 @default.
• W2893478136 cites W2564128565 @default.
• W2893478136 cites W2580705712 @default.
• W2893478136 cites W2608469458 @default.
• W2893478136 cites W2778063035 @default.
• W2893478136 cites W2781525129 @default.
• W2893478136 cites W2791728205 @default.
• W2893478136 cites W2982019201 @default.
• W2893478136 cites W839167046 @default.
• W2893478136 doi "https://doi.org/10.1038/s41419-018-0969-z" @default.
• W2893478136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155366" @default.
• W2893478136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250169" @default.
• W2893478136 hasPublicationYear "2018" @default.
• W2893478136 type Work @default.
• W2893478136 sameAs 2893478136 @default.
• W2893478136 citedByCount "24" @default.
• W2893478136 countsByYear W28934781362019 @default.
• W2893478136 countsByYear W28934781362020 @default.
• W2893478136 countsByYear W28934781362021 @default.
• W2893478136 countsByYear W28934781362022 @default.
• W2893478136 countsByYear W28934781362023 @default.
• W2893478136 crossrefType "journal-article" @default.
• W2893478136 hasAuthorship W2893478136A5009353842 @default.
• W2893478136 hasAuthorship W2893478136A5020497057 @default.
• W2893478136 hasAuthorship W2893478136A5028895704 @default.
• W2893478136 hasAuthorship W2893478136A5029409399 @default.
• W2893478136 hasAuthorship W2893478136A5035553951 @default.
• W2893478136 hasAuthorship W2893478136A5057453932 @default.
• W2893478136 hasAuthorship W2893478136A5087777979 @default.
• W2893478136 hasBestOaLocation W28934781361 @default.
• W2893478136 hasConcept C104317684 @default.
• W2893478136 hasConcept C121608353 @default.
• W2893478136 hasConcept C127561419 @default.
• W2893478136 hasConcept C145059251 @default.
• W2893478136 hasConcept C170240278 @default.
• W2893478136 hasConcept C173396325 @default.
• W2893478136 hasConcept C2779013556 @default.
• W2893478136 hasConcept C2781197716 @default.
• W2893478136 hasConcept C29537977 @default.
• W2893478136 hasConcept C502942594 @default.
• W2893478136 hasConcept C54355233 @default.
• W2893478136 hasConcept C62203573 @default.
• W2893478136 hasConcept C6929976 @default.
• W2893478136 hasConcept C71924100 @default.
• W2893478136 hasConcept C81885089 @default.
• W2893478136 hasConcept C86803240 @default.
• W2893478136 hasConceptScore W2893478136C104317684 @default.
• W2893478136 hasConceptScore W2893478136C121608353 @default.
• W2893478136 hasConceptScore W2893478136C127561419 @default.
• W2893478136 hasConceptScore W2893478136C145059251 @default.
• W2893478136 hasConceptScore W2893478136C170240278 @default.
• W2893478136 hasConceptScore W2893478136C173396325 @default.
• W2893478136 hasConceptScore W2893478136C2779013556 @default.
• W2893478136 hasConceptScore W2893478136C2781197716 @default.
• W2893478136 hasConceptScore W2893478136C29537977 @default.
• W2893478136 hasConceptScore W2893478136C502942594 @default.
• W2893478136 hasConceptScore W2893478136C54355233 @default.
• W2893478136 hasConceptScore W2893478136C62203573 @default.
• W2893478136 hasConceptScore W2893478136C6929976 @default.
• W2893478136 hasConceptScore W2893478136C71924100 @default.
• W2893478136 hasConceptScore W2893478136C81885089 @default.
• W2893478136 hasConceptScore W2893478136C86803240 @default.
• W2893478136 hasFunder F4320321001 @default.
• W2893478136 hasIssue "10" @default.
• W2893478136 hasLocation W28934781361 @default.
• W2893478136 hasLocation W28934781362 @default.

• next