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- W2893480143 abstract "Hexuronate catabolic pathways and their transcriptional networks are highly variable among different bacteria. We identified novel transcriptional regulators that control the hexuronate and aldarate utilization genes in four families of proteobacteria. By regulon reconstruction and genome context analysis we identified several novel components of the common hexuronate/aldarate utilization pathways, including novel uptake transporters and catabolic enzymes. Two novel families of lactonases involved in the oxidative pathway of hexuronate catabolism were characterized. Novel transcriptional regulons were validated via in vitro binding assays and gene expression studies with Polaromonas and Ralstonia species. The reconstructed catabolic pathways are interconnected with each other metabolically and coregulated via the GguR regulons in proteobacteria." @default.
- W2893480143 created "2018-10-05" @default.
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- W2893480143 date "2019-01-15" @default.
- W2893480143 modified "2023-10-17" @default.
- W2893480143 title "Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria" @default.
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- W2893480143 doi "https://doi.org/10.1128/jb.00431-18" @default.
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