FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893481706> ?p ?o ?g. }

• W2893481706 endingPage "1566" @default.
• W2893481706 startingPage "1553" @default.
• W2893481706 abstract "Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamine neurotransmitters and dietary amines. Two pharmacological types with different substrate and inhibitor specificities were reported. Molecular cloning revealed that the two types of MAO were different genes expressed as different proteins with different functions. MAO A and B have identical intron-exon organization derived by duplication of a common ancestral gene thus they are termed isoenzymes. MAO A knockout mice exhibited aggression, the first clear evidence linking genes to behavior. MAO A KO mice exhibited autistic-like behaviors which could be prevented by reducing serotonin levels at an early developmental age (P1-P7) providing potential therapy. MAO B KO mice were non-aggressive and resistant to Parkinsongenic neurotoxin. More recently it was found that MAO A is overexpressed in prostate cancer and correlates with degree of malignancy. The oncogenic mechanism involves a ROS-activated AKT/FOXO1/TWIST1 signaling pathway. Deletion of MAO A reduced prostate cancer stem cells and suppressed invasive adenocarcinoma. MAO A was also overexpressed in classical Hodgkin lymphoma and glioma brain tumors. MAO B was overexpressed in glioma and non-small cell lung cancer. MAO A inhibitors reduce the growth of prostate cancer, drug sensitive and resistant gliomas and classical Hodgkin lymphoma, and enhance standard chemotherapy. Currently, we are developing NIR dye-conjugated clorgyline (MAO A inhibitor) as a novel dual therapeutic/diagnostic agent for cancer. A phase II clinical trial of MAO inhibitor for biochemical recurrent prostate cancer is ongoing. The role of MAO A and B in several cancer types opens new avenues for cancer therapies." @default.
• W2893481706 created "2018-10-05" @default.
• W2893481706 creator A5059277121 @default.
• W2893481706 date "2018-09-27" @default.
• W2893481706 modified "2023-10-14" @default.
• W2893481706 title "Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy" @default.
• W2893481706 cites W123119829 @default.
• W2893481706 cites W1526582769 @default.
• W2893481706 cites W1534417549 @default.
• W2893481706 cites W1736849844 @default.
• W2893481706 cites W1964805904 @default.
• W2893481706 cites W1968257988 @default.
• W2893481706 cites W1979859269 @default.
• W2893481706 cites W1980924485 @default.
• W2893481706 cites W1990761421 @default.
• W2893481706 cites W2000158828 @default.
• W2893481706 cites W2000474355 @default.
• W2893481706 cites W2004175153 @default.
• W2893481706 cites W2004185567 @default.
• W2893481706 cites W2006600496 @default.
• W2893481706 cites W2008990415 @default.
• W2893481706 cites W2013683862 @default.
• W2893481706 cites W2013684533 @default.
• W2893481706 cites W2014970890 @default.
• W2893481706 cites W2020223470 @default.
• W2893481706 cites W2024298846 @default.
• W2893481706 cites W2042389550 @default.
• W2893481706 cites W2046592449 @default.
• W2893481706 cites W2047621093 @default.
• W2893481706 cites W2055023373 @default.
• W2893481706 cites W2055055391 @default.
• W2893481706 cites W2055688568 @default.
• W2893481706 cites W2057516812 @default.
• W2893481706 cites W2063296525 @default.
• W2893481706 cites W2063810445 @default.
• W2893481706 cites W2068027420 @default.
• W2893481706 cites W2069348138 @default.
• W2893481706 cites W2078720029 @default.
• W2893481706 cites W2080971527 @default.
• W2893481706 cites W2085936836 @default.
• W2893481706 cites W2086551867 @default.
• W2893481706 cites W2086858085 @default.
• W2893481706 cites W2088076795 @default.
• W2893481706 cites W2089462977 @default.
• W2893481706 cites W2106530957 @default.
• W2893481706 cites W2110526976 @default.
• W2893481706 cites W2128964111 @default.
• W2893481706 cites W2134996660 @default.
• W2893481706 cites W2138288043 @default.
• W2893481706 cites W2149472336 @default.
• W2893481706 cites W2160683179 @default.
• W2893481706 cites W2165950251 @default.
• W2893481706 cites W2267963721 @default.
• W2893481706 cites W2274235622 @default.
• W2893481706 cites W2279478287 @default.
• W2893481706 cites W2290606825 @default.
• W2893481706 cites W2305511830 @default.
• W2893481706 cites W2327988534 @default.
• W2893481706 cites W2328700233 @default.
• W2893481706 cites W2472928215 @default.
• W2893481706 cites W2607224988 @default.
• W2893481706 cites W2616318791 @default.
• W2893481706 cites W2737588912 @default.
• W2893481706 cites W2757837983 @default.
• W2893481706 cites W2770499238 @default.
• W2893481706 cites W2799849376 @default.
• W2893481706 cites W2802120262 @default.
• W2893481706 cites W2806710458 @default.
• W2893481706 doi "https://doi.org/10.1007/s00702-018-1927-8" @default.
• W2893481706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6245662" @default.
• W2893481706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259128" @default.
• W2893481706 hasPublicationYear "2018" @default.
• W2893481706 type Work @default.
• W2893481706 sameAs 2893481706 @default.
• W2893481706 citedByCount "72" @default.
• W2893481706 countsByYear W28934817062019 @default.
• W2893481706 countsByYear W28934817062020 @default.
• W2893481706 countsByYear W28934817062021 @default.
• W2893481706 countsByYear W28934817062022 @default.
• W2893481706 countsByYear W28934817062023 @default.
• W2893481706 crossrefType "journal-article" @default.
• W2893481706 hasAuthorship W2893481706A5059277121 @default.
• W2893481706 hasBestOaLocation W28934817062 @default.
• W2893481706 hasConcept C114461151 @default.
• W2893481706 hasConcept C121608353 @default.
• W2893481706 hasConcept C181199279 @default.
• W2893481706 hasConcept C2776024655 @default.
• W2893481706 hasConcept C2780192828 @default.
• W2893481706 hasConcept C2910293678 @default.
• W2893481706 hasConcept C39398028 @default.
• W2893481706 hasConcept C502942594 @default.
• W2893481706 hasConcept C54355233 @default.
• W2893481706 hasConcept C55493867 @default.
• W2893481706 hasConcept C86803240 @default.
• W2893481706 hasConceptScore W2893481706C114461151 @default.
• W2893481706 hasConceptScore W2893481706C121608353 @default.
• W2893481706 hasConceptScore W2893481706C181199279 @default.
• W2893481706 hasConceptScore W2893481706C2776024655 @default.

• next