Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893482711> ?p ?o ?g. }
- W2893482711 abstract "Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues. Those PS can be divided by its specific efficiency of ROS generation, absorption wavelength and chemical structure. Up to dates, several PS were approved for clinical applications or under clinical trials. Photofrin® is the first clinically approved photosensitizer for the treatment of cancer. The second generation of PS, Porfimer sodium (Photofrin®), Temoporfin (Foscan®), Motexafin lutetium, Palladium bacteriopheophorbide, Purlytin®, Verteporfin (Visudyne®), Talaporfin (Laserphyrin®) are clinically approved or under-clinical trials. Now, third generation of PS, which can dramatically improve cancer-targeting efficiency by chemical modification, nano-delivery system or antibody conjugation, are extensively studied for clinical development. Here, we discuss up-to-date information on FDA-approved photodynamic agents, the clinical benefits of these agents. However, PDT is still dearth for the treatment of diseases in specifically deep tissue cancer. Next generation PS will be addressed in the future for PDT. We also provide clinical unmet need for the design of new photosensitizers." @default.
- W2893482711 created "2018-10-05" @default.
- W2893482711 creator A5000379559 @default.
- W2893482711 creator A5042254280 @default.
- W2893482711 creator A5080530170 @default.
- W2893482711 date "2018-09-26" @default.
- W2893482711 modified "2023-10-16" @default.
- W2893482711 title "Clinical development of photodynamic agents and therapeutic applications" @default.
- W2893482711 cites W148909682 @default.
- W2893482711 cites W1596848781 @default.
- W2893482711 cites W1784512359 @default.
- W2893482711 cites W1963738331 @default.
- W2893482711 cites W1965478861 @default.
- W2893482711 cites W1969571726 @default.
- W2893482711 cites W1970220987 @default.
- W2893482711 cites W1978809370 @default.
- W2893482711 cites W1991782498 @default.
- W2893482711 cites W1991880013 @default.
- W2893482711 cites W1992600137 @default.
- W2893482711 cites W1997244032 @default.
- W2893482711 cites W1999051172 @default.
- W2893482711 cites W2004702311 @default.
- W2893482711 cites W2006273955 @default.
- W2893482711 cites W2010480855 @default.
- W2893482711 cites W2013316743 @default.
- W2893482711 cites W2013780254 @default.
- W2893482711 cites W2014142534 @default.
- W2893482711 cites W2018722597 @default.
- W2893482711 cites W2023460100 @default.
- W2893482711 cites W2026889493 @default.
- W2893482711 cites W2032452990 @default.
- W2893482711 cites W2034653177 @default.
- W2893482711 cites W2035788788 @default.
- W2893482711 cites W2039730458 @default.
- W2893482711 cites W2041053167 @default.
- W2893482711 cites W2045123489 @default.
- W2893482711 cites W2049887991 @default.
- W2893482711 cites W2050200512 @default.
- W2893482711 cites W2055224862 @default.
- W2893482711 cites W2077984066 @default.
- W2893482711 cites W2078645402 @default.
- W2893482711 cites W2081495891 @default.
- W2893482711 cites W2089027919 @default.
- W2893482711 cites W2090565388 @default.
- W2893482711 cites W2098804178 @default.
- W2893482711 cites W2108747220 @default.
- W2893482711 cites W2113594381 @default.
- W2893482711 cites W2114994946 @default.
- W2893482711 cites W2115914766 @default.
- W2893482711 cites W2130213417 @default.
- W2893482711 cites W2131408793 @default.
- W2893482711 cites W2133440494 @default.
- W2893482711 cites W2138227433 @default.
- W2893482711 cites W2142444030 @default.
- W2893482711 cites W2145213448 @default.
- W2893482711 cites W2151734986 @default.
- W2893482711 cites W2154417623 @default.
- W2893482711 cites W2157633101 @default.
- W2893482711 cites W2160029055 @default.
- W2893482711 cites W2161781015 @default.
- W2893482711 cites W2162759408 @default.
- W2893482711 cites W2166164748 @default.
- W2893482711 cites W2169101925 @default.
- W2893482711 cites W2293064137 @default.
- W2893482711 cites W2341300569 @default.
- W2893482711 cites W2409121032 @default.
- W2893482711 cites W2411482082 @default.
- W2893482711 cites W2414744424 @default.
- W2893482711 cites W2424204986 @default.
- W2893482711 cites W2525054539 @default.
- W2893482711 cites W2566433825 @default.
- W2893482711 cites W2618388183 @default.
- W2893482711 cites W2744550874 @default.
- W2893482711 cites W2791561783 @default.
- W2893482711 cites W4233168373 @default.
- W2893482711 cites W4300859653 @default.
- W2893482711 doi "https://doi.org/10.1186/s40824-018-0140-z" @default.
- W2893482711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158913" @default.
- W2893482711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275968" @default.
- W2893482711 hasPublicationYear "2018" @default.
- W2893482711 type Work @default.
- W2893482711 sameAs 2893482711 @default.
- W2893482711 citedByCount "310" @default.
- W2893482711 countsByYear W28934827112019 @default.
- W2893482711 countsByYear W28934827112020 @default.
- W2893482711 countsByYear W28934827112021 @default.
- W2893482711 countsByYear W28934827112022 @default.
- W2893482711 countsByYear W28934827112023 @default.
- W2893482711 crossrefType "journal-article" @default.
- W2893482711 hasAuthorship W2893482711A5000379559 @default.
- W2893482711 hasAuthorship W2893482711A5042254280 @default.
- W2893482711 hasAuthorship W2893482711A5080530170 @default.
- W2893482711 hasBestOaLocation W28934827111 @default.
- W2893482711 hasConcept C118487528 @default.
- W2893482711 hasConcept C121608353 @default.
- W2893482711 hasConcept C126322002 @default.
- W2893482711 hasConcept C178790620 @default.
- W2893482711 hasConcept C185592680 @default.
- W2893482711 hasConcept C2776403814 @default.
- W2893482711 hasConcept C2777516457 @default.