FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893485077> ?p ?o ?g. }

• W2893485077 abstract "Summary All organisms possess several DNA repair pathways to maintain the integrity of their genetic material. Although there are several DNA repair pathways that are well understood, we recently identified several genes in Bacillus subtilis that are important for surviving treatment with drugs that damage DNA. Here, we report a drug specific DNA repair pathway in B. subtilis . We identified genes coding for a previously uncharacterized helicase and exonuclease, mrfA and mrfB , respectively. Deletion of mrfA and mrfB resulted in sensitivity to the DNA damaging agent mitomycin C, but not other types of DNA damage. We found that MrfAB operate independently of canonical nucleotide excision repair, forming a novel excision repair pathway in bacteria. A phylogenetic analysis demonstrates that MrfAB homologs are present in diverse bacterial phyla, and a cross-complementation assay shows that MrfAB function is conserved in closely related species. Mitomycin C is a natural antibiotic that is produced by the soil dwelling bacterium Streptomyces lavendulae , and B. subtilis is also a soil dwelling organism. The specificity of the Δ mrfAB phenotype suggests that MrfAB have been adapted as a countermeasure to mitomycin producing bacteria. Abbreviated Summary Bacteria possess DNA repair pathways to maintain the integrity of their genetic material. The helicase MrfA and the exonuclease MrfB are part of a mitomycin C specific DNA repair pathway in Bacillus subtilis . Despite being present in many bacterial species, MrfAB activity in repairing MMC damaged DNA appears to be restricted to closely related species, suggesting that these proteins have likely been adapted to the specific needs of each bacterium." @default.
• W2893485077 created "2018-10-05" @default.
• W2893485077 creator A5012172104 @default.
• W2893485077 creator A5066840372 @default.
• W2893485077 date "2018-09-26" @default.
• W2893485077 modified "2023-10-18" @default.
• W2893485077 title "A bacterial DNA repair pathway specific to a natural antibiotic" @default.
• W2893485077 cites W1529247520 @default.
• W2893485077 cites W1569631204 @default.
• W2893485077 cites W1803102843 @default.
• W2893485077 cites W1825544386 @default.
• W2893485077 cites W1972116779 @default.
• W2893485077 cites W1988625619 @default.
• W2893485077 cites W1994875540 @default.
• W2893485077 cites W1999235659 @default.
• W2893485077 cites W1999428699 @default.
• W2893485077 cites W2007328360 @default.
• W2893485077 cites W2010436676 @default.
• W2893485077 cites W2024836674 @default.
• W2893485077 cites W2028326921 @default.
• W2893485077 cites W2029639437 @default.
• W2893485077 cites W2033271892 @default.
• W2893485077 cites W2034159958 @default.
• W2893485077 cites W2040100388 @default.
• W2893485077 cites W2053690536 @default.
• W2893485077 cites W2060583705 @default.
• W2893485077 cites W2067169557 @default.
• W2893485077 cites W2078247519 @default.
• W2893485077 cites W2078446890 @default.
• W2893485077 cites W2087860209 @default.
• W2893485077 cites W2089387760 @default.
• W2893485077 cites W2090311343 @default.
• W2893485077 cites W2091666349 @default.
• W2893485077 cites W2097706568 @default.
• W2893485077 cites W2106203512 @default.
• W2893485077 cites W2109830330 @default.
• W2893485077 cites W2118022632 @default.
• W2893485077 cites W2123352677 @default.
• W2893485077 cites W2125801802 @default.
• W2893485077 cites W2132926880 @default.
• W2893485077 cites W2140755586 @default.
• W2893485077 cites W2144481268 @default.
• W2893485077 cites W2149456142 @default.
• W2893485077 cites W2153795802 @default.
• W2893485077 cites W2167414731 @default.
• W2893485077 cites W2311203695 @default.
• W2893485077 cites W2404768705 @default.
• W2893485077 cites W2515616885 @default.
• W2893485077 cites W2516679603 @default.
• W2893485077 cites W2544893035 @default.
• W2893485077 cites W2590204906 @default.
• W2893485077 cites W2727035568 @default.
• W2893485077 cites W2736743088 @default.
• W2893485077 cites W2774908616 @default.
• W2893485077 cites W2861196920 @default.
• W2893485077 cites W4254275792 @default.
• W2893485077 doi "https://doi.org/10.1101/426304" @default.
• W2893485077 hasPublicationYear "2018" @default.
• W2893485077 type Work @default.
• W2893485077 sameAs 2893485077 @default.
• W2893485077 citedByCount "1" @default.
• W2893485077 countsByYear W28934850772021 @default.
• W2893485077 crossrefType "posted-content" @default.
• W2893485077 hasAuthorship W2893485077A5012172104 @default.
• W2893485077 hasAuthorship W2893485077A5066840372 @default.
• W2893485077 hasBestOaLocation W28934850771 @default.
• W2893485077 hasConcept C104317684 @default.
• W2893485077 hasConcept C104451858 @default.
• W2893485077 hasConcept C134935766 @default.
• W2893485077 hasConcept C143425029 @default.
• W2893485077 hasConcept C161223559 @default.
• W2893485077 hasConcept C2756471 @default.
• W2893485077 hasConcept C2777272437 @default.
• W2893485077 hasConcept C2777501222 @default.
• W2893485077 hasConcept C523546767 @default.
• W2893485077 hasConcept C54355233 @default.
• W2893485077 hasConcept C552990157 @default.
• W2893485077 hasConcept C67705224 @default.
• W2893485077 hasConcept C86803240 @default.
• W2893485077 hasConceptScore W2893485077C104317684 @default.
• W2893485077 hasConceptScore W2893485077C104451858 @default.
• W2893485077 hasConceptScore W2893485077C134935766 @default.
• W2893485077 hasConceptScore W2893485077C143425029 @default.
• W2893485077 hasConceptScore W2893485077C161223559 @default.
• W2893485077 hasConceptScore W2893485077C2756471 @default.
• W2893485077 hasConceptScore W2893485077C2777272437 @default.
• W2893485077 hasConceptScore W2893485077C2777501222 @default.
• W2893485077 hasConceptScore W2893485077C523546767 @default.
• W2893485077 hasConceptScore W2893485077C54355233 @default.
• W2893485077 hasConceptScore W2893485077C552990157 @default.
• W2893485077 hasConceptScore W2893485077C67705224 @default.
• W2893485077 hasConceptScore W2893485077C86803240 @default.
• W2893485077 hasLocation W28934850771 @default.
• W2893485077 hasLocation W28934850772 @default.
• W2893485077 hasLocation W28934850773 @default.
• W2893485077 hasOpenAccess W2893485077 @default.
• W2893485077 hasPrimaryLocation W28934850771 @default.
• W2893485077 hasRelatedWork W1746630368 @default.
• W2893485077 hasRelatedWork W1862183444 @default.
• W2893485077 hasRelatedWork W2048565695 @default.

• next