Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893485339> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2893485339 abstract "MicroRNAs are endogenous non-coding RNAs of 21–23 nt which regulate target gene expression at the posttranscriptional level typically through either translational repression or mRNA cleavage. Recent developments have revealed that there is extensive of miRNAs as well as miRNA pathways related proteins in cell nucleus, leading us to hypothesize that nucleus microRNAs might have their own functions. We observed that a specific microRNA, miR-709, is detected in nucleus fraction preparing from various mouse cell lines as well as tissues samples. In cell nucleus miR-709 will meet and bind its target, pri-miR-15a/16-1, which is a primary transcript for another microRNA cluster: miR-15a and miR-16. Such binding will prevent pri-miR-15a/16-1 processing in nucleus and thus regulate miR-15a/16 maturation at the pri-miRNA to pre-miRNA stage. Furthermore, nucleus miR-709 participates cell apoptosis through BCL2-miR-15a/16 pathway. Our data indicates that one microRNA can directly target another microRNA's primary transcript in nucleus and regulate its biogenesis via this pathway. In conclusion this association may further suggest a “microRNA hierarchy” system in biological world." @default.
- W2893485339 created "2018-10-05" @default.
- W2893485339 creator A5018794859 @default.
- W2893485339 creator A5022218511 @default.
- W2893485339 creator A5036985869 @default.
- W2893485339 creator A5037203763 @default.
- W2893485339 creator A5044756293 @default.
- W2893485339 creator A5048976159 @default.
- W2893485339 creator A5082076770 @default.
- W2893485339 date "2011-04-01" @default.
- W2893485339 modified "2023-10-18" @default.
- W2893485339 title "miR‐709 regulates miR‐15a/16 biogenesis at post‐transcriptional level in nucleus: an implication of a microRNA hierarchy system" @default.
- W2893485339 doi "https://doi.org/10.1096/fasebj.25.1_supplement.899.4" @default.
- W2893485339 hasPublicationYear "2011" @default.
- W2893485339 type Work @default.
- W2893485339 sameAs 2893485339 @default.
- W2893485339 citedByCount "0" @default.
- W2893485339 crossrefType "journal-article" @default.
- W2893485339 hasAuthorship W2893485339A5018794859 @default.
- W2893485339 hasAuthorship W2893485339A5022218511 @default.
- W2893485339 hasAuthorship W2893485339A5036985869 @default.
- W2893485339 hasAuthorship W2893485339A5037203763 @default.
- W2893485339 hasAuthorship W2893485339A5044756293 @default.
- W2893485339 hasAuthorship W2893485339A5048976159 @default.
- W2893485339 hasAuthorship W2893485339A5082076770 @default.
- W2893485339 hasConcept C104317684 @default.
- W2893485339 hasConcept C131934819 @default.
- W2893485339 hasConcept C145059251 @default.
- W2893485339 hasConcept C1491633281 @default.
- W2893485339 hasConcept C2780114586 @default.
- W2893485339 hasConcept C2780723820 @default.
- W2893485339 hasConcept C54355233 @default.
- W2893485339 hasConcept C86803240 @default.
- W2893485339 hasConcept C95444343 @default.
- W2893485339 hasConceptScore W2893485339C104317684 @default.
- W2893485339 hasConceptScore W2893485339C131934819 @default.
- W2893485339 hasConceptScore W2893485339C145059251 @default.
- W2893485339 hasConceptScore W2893485339C1491633281 @default.
- W2893485339 hasConceptScore W2893485339C2780114586 @default.
- W2893485339 hasConceptScore W2893485339C2780723820 @default.
- W2893485339 hasConceptScore W2893485339C54355233 @default.
- W2893485339 hasConceptScore W2893485339C86803240 @default.
- W2893485339 hasConceptScore W2893485339C95444343 @default.
- W2893485339 hasIssue "S1" @default.
- W2893485339 hasLocation W28934853391 @default.
- W2893485339 hasOpenAccess W2893485339 @default.
- W2893485339 hasPrimaryLocation W28934853391 @default.
- W2893485339 hasRelatedWork W2001775831 @default.
- W2893485339 hasRelatedWork W2012427498 @default.
- W2893485339 hasRelatedWork W2027063964 @default.
- W2893485339 hasRelatedWork W2076886405 @default.
- W2893485339 hasRelatedWork W2089171495 @default.
- W2893485339 hasRelatedWork W2383761321 @default.
- W2893485339 hasRelatedWork W2424626940 @default.
- W2893485339 hasRelatedWork W2891496493 @default.
- W2893485339 hasRelatedWork W3131972508 @default.
- W2893485339 hasRelatedWork W3147677399 @default.
- W2893485339 hasVolume "25" @default.
- W2893485339 isParatext "false" @default.
- W2893485339 isRetracted "false" @default.
- W2893485339 magId "2893485339" @default.
- W2893485339 workType "article" @default.