FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893485951> ?p ?o ?g. }

• W2893485951 endingPage "611" @default.
• W2893485951 startingPage "603" @default.
• W2893485951 abstract "As alternative indexes of hepatitis B virus (HBV), covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg), and peripheral blood RNA known as pgRNA, have been advocated as novel serum markers for prediction of prognosis and treatment response in chronic hepatitis B (CHB). Since the availability of commercial quantitative assays of HBsAg in 2011, HBsAg has been widely used for predicting treatment response of patients with CHB. Patients who received interferon therapy have shown a sharper reduction of HBsAg level than those who received nucleoside drug (NAs) therapy. Upon peginterferon treatment, sustained responders have presented a larger reduction of HBsAg level than the non-responders. An absence of HBsAg decline, together with < 2log reduction in HBV DNA at week 12, can serve as a stopping rule in HBsAg-negative patients infected with genotype D HBV. A sharp reduction of HBsAg titer in the NAs therapy is a predictor of HBsAg clearance in long-term treatment. HBcrAg, which consists of three species of related proteins sharing an identical 149 amino acid sequence, including HbcAg, hepatitis B e antigen (HBeAg), and a truncated 22-kDa precore protein, is still detectable in situations where serum HBV DNA levels become undetectable or HBsAg loss is achieved. Therefore, HBcrAg remains a measurable serum marker to correlate with cccDNA in this situation. The decline in HBcrAg has been observed with NAs therapy and the pattern of decline might provide prognostic information on the risk of HBV post-treatment reactivation. Peripheral blood RNA, which is known as pgRNA, directly derives from cccDNA and reflects intrahepatic cccDNA level. Quantitative pgRNA has been suggested to be helpful in CHB management. However, commercial quantitative assays are lacking. Additionally, the use of simultaneous and continuous clearance of HBV RNA and HBV DNA in serum has been suggested to be a safe stopping rule of NAs therapy for patients with CHB. However, clinical studies of large sample sizes are needed to prove the feasibility and significance of using serum HBV RNA as the assessment standard of antiviral therapy in CHB and the safety of the stopping rule in clinics." @default.
• W2893485951 created "2018-10-05" @default.
• W2893485951 creator A5039427179 @default.
• W2893485951 creator A5084367642 @default.
• W2893485951 date "2018-09-27" @default.
• W2893485951 modified "2023-10-17" @default.
• W2893485951 title "Progression and status of antiviral monitoring in patients with chronic hepatitis B: From HBsAg to HBV RNA" @default.
• W2893485951 cites W118409507 @default.
• W2893485951 cites W1546449054 @default.
• W2893485951 cites W1555699566 @default.
• W2893485951 cites W175109609 @default.
• W2893485951 cites W1967163020 @default.
• W2893485951 cites W1975550487 @default.
• W2893485951 cites W1976470893 @default.
• W2893485951 cites W1989070801 @default.
• W2893485951 cites W1990656080 @default.
• W2893485951 cites W1993331451 @default.
• W2893485951 cites W1996074478 @default.
• W2893485951 cites W1997681955 @default.
• W2893485951 cites W1997802763 @default.
• W2893485951 cites W1998109795 @default.
• W2893485951 cites W1998881478 @default.
• W2893485951 cites W2006701618 @default.
• W2893485951 cites W2009234274 @default.
• W2893485951 cites W2009509017 @default.
• W2893485951 cites W2010814575 @default.
• W2893485951 cites W2026179924 @default.
• W2893485951 cites W2026535163 @default.
• W2893485951 cites W2027543203 @default.
• W2893485951 cites W2032812836 @default.
• W2893485951 cites W2033837061 @default.
• W2893485951 cites W2040778023 @default.
• W2893485951 cites W2041849739 @default.
• W2893485951 cites W2042329639 @default.
• W2893485951 cites W2044951291 @default.
• W2893485951 cites W2045853963 @default.
• W2893485951 cites W2047537244 @default.
• W2893485951 cites W2056892996 @default.
• W2893485951 cites W2059560167 @default.
• W2893485951 cites W2062462673 @default.
• W2893485951 cites W2070905287 @default.
• W2893485951 cites W2071337588 @default.
• W2893485951 cites W2074118280 @default.
• W2893485951 cites W2074622990 @default.
• W2893485951 cites W2076571011 @default.
• W2893485951 cites W2080510142 @default.
• W2893485951 cites W2082534929 @default.
• W2893485951 cites W2088599718 @default.
• W2893485951 cites W2089908069 @default.
• W2893485951 cites W2092651879 @default.
• W2893485951 cites W2103704471 @default.
• W2893485951 cites W2104427317 @default.
• W2893485951 cites W2112912232 @default.
• W2893485951 cites W2118237249 @default.
• W2893485951 cites W2122662991 @default.
• W2893485951 cites W2142338711 @default.
• W2893485951 cites W2143638462 @default.
• W2893485951 cites W2155687271 @default.
• W2893485951 cites W2157039129 @default.
• W2893485951 cites W2169631718 @default.
• W2893485951 cites W2173698250 @default.
• W2893485951 cites W2208817615 @default.
• W2893485951 cites W2393327590 @default.
• W2893485951 cites W2408333651 @default.
• W2893485951 cites W2422356872 @default.
• W2893485951 cites W2766670674 @default.
• W2893485951 cites W2781895897 @default.
• W2893485951 cites W317373044 @default.
• W2893485951 cites W3202285235 @default.
• W2893485951 cites W4211026375 @default.
• W2893485951 doi "https://doi.org/10.4254/wjh.v10.i9.603" @default.
• W2893485951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6177569" @default.
• W2893485951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310538" @default.
• W2893485951 hasPublicationYear "2018" @default.
• W2893485951 type Work @default.
• W2893485951 sameAs 2893485951 @default.
• W2893485951 citedByCount "19" @default.
• W2893485951 countsByYear W28934859512019 @default.
• W2893485951 countsByYear W28934859512020 @default.
• W2893485951 countsByYear W28934859512021 @default.
• W2893485951 countsByYear W28934859512022 @default.
• W2893485951 countsByYear W28934859512023 @default.
• W2893485951 crossrefType "journal-article" @default.
• W2893485951 hasAuthorship W2893485951A5039427179 @default.
• W2893485951 hasAuthorship W2893485951A5084367642 @default.
• W2893485951 hasBestOaLocation W28934859511 @default.
• W2893485951 hasConcept C147483822 @default.
• W2893485951 hasConcept C159047783 @default.
• W2893485951 hasConcept C189490182 @default.
• W2893485951 hasConcept C203014093 @default.
• W2893485951 hasConcept C2522874641 @default.
• W2893485951 hasConcept C2775940106 @default.
• W2893485951 hasConcept C2777382497 @default.
• W2893485951 hasConcept C2777410769 @default.
• W2893485951 hasConcept C2779729466 @default.
• W2893485951 hasConcept C2780593183 @default.
• W2893485951 hasConcept C71924100 @default.
• W2893485951 hasConceptScore W2893485951C147483822 @default.

• next