Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893486873> ?p ?o ?g. }
- W2893486873 abstract "Abstract Prebiotic nucleotide synthesis is crucial to understanding the origins of life on Earth. There are numerous candidates for life’s first nucleic acid, however, currently no prebiotic method to selectively and concurrently synthesise the canonical Watson–Crick base-pairing pyrimidine (C, U) and purine (A, G) nucleosides exists for any genetic polymer. Here, we demonstrate the divergent prebiotic synthesis of arabinonucleic acid (ANA) nucleosides. The complete set of canonical nucleosides is delivered from one reaction sequence, with regiospecific glycosidation and complete furanosyl selectivity. We observe photochemical 8-mercaptopurine reduction is efficient for the canonical purines (A, G), but not the non-canonical purine inosine (I). Our results demonstrate that synthesis of ANA may have been facile under conditions that comply with plausible geochemical environments on early Earth and, given that ANA is capable of encoding RNA/DNA compatible information and evolving to yield catalytic ANA-zymes, ANA may have played a critical role during the origins of life." @default.
- W2893486873 created "2018-10-05" @default.
- W2893486873 creator A5011223466 @default.
- W2893486873 creator A5014407906 @default.
- W2893486873 creator A5017582006 @default.
- W2893486873 creator A5020767671 @default.
- W2893486873 creator A5022129586 @default.
- W2893486873 creator A5026399646 @default.
- W2893486873 creator A5044695461 @default.
- W2893486873 creator A5051925769 @default.
- W2893486873 date "2018-10-04" @default.
- W2893486873 modified "2023-10-18" @default.
- W2893486873 title "Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water" @default.
- W2893486873 cites W1517927116 @default.
- W2893486873 cites W1534726296 @default.
- W2893486873 cites W1549279075 @default.
- W2893486873 cites W1964369479 @default.
- W2893486873 cites W1985693800 @default.
- W2893486873 cites W1990345925 @default.
- W2893486873 cites W1991087940 @default.
- W2893486873 cites W1993449464 @default.
- W2893486873 cites W2001363398 @default.
- W2893486873 cites W2008252116 @default.
- W2893486873 cites W2010556905 @default.
- W2893486873 cites W2010790220 @default.
- W2893486873 cites W2013673362 @default.
- W2893486873 cites W2022285466 @default.
- W2893486873 cites W2025713403 @default.
- W2893486873 cites W2028022118 @default.
- W2893486873 cites W2028770952 @default.
- W2893486873 cites W2031928338 @default.
- W2893486873 cites W2042037994 @default.
- W2893486873 cites W2045974535 @default.
- W2893486873 cites W2045984796 @default.
- W2893486873 cites W2050110866 @default.
- W2893486873 cites W2050696280 @default.
- W2893486873 cites W2059398338 @default.
- W2893486873 cites W2062019095 @default.
- W2893486873 cites W2066357909 @default.
- W2893486873 cites W2075002643 @default.
- W2893486873 cites W2084221475 @default.
- W2893486873 cites W2088629209 @default.
- W2893486873 cites W2092102437 @default.
- W2893486873 cites W2097764239 @default.
- W2893486873 cites W2106424251 @default.
- W2893486873 cites W2106824077 @default.
- W2893486873 cites W2112145363 @default.
- W2893486873 cites W2125903089 @default.
- W2893486873 cites W2127815126 @default.
- W2893486873 cites W2131350133 @default.
- W2893486873 cites W2133830966 @default.
- W2893486873 cites W2141542554 @default.
- W2893486873 cites W2142997566 @default.
- W2893486873 cites W2147204536 @default.
- W2893486873 cites W2150067038 @default.
- W2893486873 cites W2158076397 @default.
- W2893486873 cites W2165194928 @default.
- W2893486873 cites W219287239 @default.
- W2893486873 cites W2314493427 @default.
- W2893486873 cites W2317913417 @default.
- W2893486873 cites W2386517417 @default.
- W2893486873 cites W2527729894 @default.
- W2893486873 cites W2531224844 @default.
- W2893486873 cites W2554800362 @default.
- W2893486873 cites W2578576796 @default.
- W2893486873 cites W2605265031 @default.
- W2893486873 cites W2605841420 @default.
- W2893486873 cites W2606905320 @default.
- W2893486873 cites W2611894198 @default.
- W2893486873 cites W2616496046 @default.
- W2893486873 cites W2763165835 @default.
- W2893486873 cites W2777243394 @default.
- W2893486873 cites W2950702549 @default.
- W2893486873 cites W2953350983 @default.
- W2893486873 cites W3121191799 @default.
- W2893486873 cites W3122449024 @default.
- W2893486873 cites W4241240414 @default.
- W2893486873 doi "https://doi.org/10.1038/s41467-018-06374-z" @default.
- W2893486873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172253" @default.
- W2893486873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287815" @default.
- W2893486873 hasPublicationYear "2018" @default.
- W2893486873 type Work @default.
- W2893486873 sameAs 2893486873 @default.
- W2893486873 citedByCount "34" @default.
- W2893486873 countsByYear W28934868732018 @default.
- W2893486873 countsByYear W28934868732019 @default.
- W2893486873 countsByYear W28934868732020 @default.
- W2893486873 countsByYear W28934868732021 @default.
- W2893486873 countsByYear W28934868732022 @default.
- W2893486873 countsByYear W28934868732023 @default.
- W2893486873 crossrefType "journal-article" @default.
- W2893486873 hasAuthorship W2893486873A5011223466 @default.
- W2893486873 hasAuthorship W2893486873A5014407906 @default.
- W2893486873 hasAuthorship W2893486873A5017582006 @default.
- W2893486873 hasAuthorship W2893486873A5020767671 @default.
- W2893486873 hasAuthorship W2893486873A5022129586 @default.
- W2893486873 hasAuthorship W2893486873A5026399646 @default.
- W2893486873 hasAuthorship W2893486873A5044695461 @default.
- W2893486873 hasAuthorship W2893486873A5051925769 @default.
- W2893486873 hasBestOaLocation W28934868731 @default.