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- W2893488908 abstract "Introduction Preeclampsia (PE) is a specific pregnancy syndrome characterized by an imbalance between the inflammatory T cell (Th1 and Th17) and the anti-inflammatory (Th2 and Treg) profiles. It seems to be dependent on the deficiency of regulatory factors such as vitamin D (VD), which exerts modulatory effects on cells of the adaptive immune system, especially T cells. Objective The study aimed to evaluate the modulatory effect of VD on T cell subsets and the production of cytokines in preeclamptic women. Methods Peripheral blood mononuclear cells obtained from 12 pregnant women with PE and 12 NT were cultured with or without VD. The cytokines IL-6, IL-10, IL-17 and TNF- α were evaluated by cytometric bead array (CBA) or ELISA. The gene expression of the transcription factors T-bet (Th1), GATA-3 (Th2), ROR γ t and RUNX1 (Th17), FoxP3 (Treg) and vitamin D receptor (VDR) were determined by the qPCR. Results Endogenous mRNA levels of T-bet, ROR γ t and RUNX1 were significantly higher, whereas GATA-3 and FoxP3 mRNA levels were lower in PE group when compared to NT women. Cell treatment with VD decreased the gene expression of T-bet, ROR γ t and RUNX1 and increased that of GATA-3, FoxP3 and VDR in preeclamptic women. Regarding the endogenous cytokines production IL-17 and TNF- α were significantly higher, while IL-10 was decreased in PE when compared to NT group. VD treatment decreased the production of IL-17 and led to a tendency of decreased levels of IL-6 and TNF- α in PE group. On the other hand, IL-10 levels increased significantly after treatment with VD in both groups. Discussion VD treatment increased GATA-3, FoxP3 and IL-10, demonstrating that this molecule is able to polarize the inflammatory response present in PE to the anti-inflammatory profile. It confirms the important immunomodulatory effect of VD in this disease. Financial support FAPESP 2016/23450–0 e 2016/18155–9" @default.
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- W2893488908 date "2018-10-01" @default.
- W2893488908 modified "2023-10-17" @default.
- W2893488908 title "173. Vitamin D modulates the inflammatory response in T cell subsets from pregnant women with preeclampsia" @default.
- W2893488908 doi "https://doi.org/10.1016/j.preghy.2018.08.086" @default.
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