FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893500083> ?p ?o ?g. }

• W2893500083 endingPage "268" @default.
• W2893500083 startingPage "258" @default.
• W2893500083 abstract "Electrically conductive polypyrrole (PPy) is an intriguing biomaterial capable of efficient electrical interactions with biological systems. Especially, biomimetic PPy-based biomaterials incorporating biomolecules, such as hyaluronic acid (HA), can impart the characteristic biological interactions with living cells/tissues to the conductive biomaterials. Here we report the effects of the molecular weight (MW) of HA on PPy-based biomaterials. We utilized HA of a wide range of MW (35 × 103 Da-3 × 106 Da) as dopants during the electrochemical production of PPy/HA films and their characterization of materials and cellular interactions. With increases in the MWs of HA dopants, PPy/HA exhibited more hydrophilic, higher electrochemical activity and lower impedance. In vitro studies revealed that PPy films doped with low MW HA were supportive to cell adhesion and growth, while PPy films doped with high MW HA were resistant to cell attachment. Subcutaneous implantation of the PPy/HA films for 4 weeks revealed that all the PPy/HA films were tissue compatible. We successfully demonstrate the importance of HA dopant MWs in modulating the chemical and electrical properties of the materials and cellular responses to the materials. Such materials have potential for various biomedical applications, including as tissue engineering scaffolds and as electrodes for neural recording and neuromodulation. STATEMENT OF SIGNIFICANCE: Hyaluronic acid (HA)-doped polypyrrole (PPy) films were electrochemically synthesized as novel biomimetic conductive materials capable of efficient electrical signaling and preferential biological interactions. Molecular weights (MWs) of HA varied in a wide range (35 × 103-2 × 106 Da) and critically determine chemical, electrochemical, and biological properties of PPy/HA. Especially, PPy films with low MW HA markedly support cell adhesion and growth, while PPy films with high MW HA are resistant to cell attachment. Furthermore, PPy/HA exhibits greatly improved tissue compatibility and in vivo EMG signal recording ability. We for the first time demonstrate that biomimetic PPy/HA-based biomaterials can serve as versatile and effective platforms for various biomedical applications, such as tissue engineering scaffolds and bioelectrodes." @default.
• W2893500083 created "2018-10-05" @default.
• W2893500083 creator A5003272190 @default.
• W2893500083 creator A5006727515 @default.
• W2893500083 creator A5011035713 @default.
• W2893500083 creator A5020152050 @default.
• W2893500083 creator A5032110952 @default.
• W2893500083 creator A5082822722 @default.
• W2893500083 creator A5089822472 @default.
• W2893500083 date "2018-10-01" @default.
• W2893500083 modified "2023-10-01" @default.
• W2893500083 title "Versatile biomimetic conductive polypyrrole films doped with hyaluronic acid of different molecular weights" @default.
• W2893500083 cites W1149703769 @default.
• W2893500083 cites W1794039655 @default.
• W2893500083 cites W1877702050 @default.
• W2893500083 cites W1969179238 @default.
• W2893500083 cites W1972277019 @default.
• W2893500083 cites W1977784832 @default.
• W2893500083 cites W1986577383 @default.
• W2893500083 cites W1988225365 @default.
• W2893500083 cites W1988901706 @default.
• W2893500083 cites W1995090980 @default.
• W2893500083 cites W2003380614 @default.
• W2893500083 cites W2009965340 @default.
• W2893500083 cites W2015952490 @default.
• W2893500083 cites W2017469060 @default.
• W2893500083 cites W2018859603 @default.
• W2893500083 cites W2027375557 @default.
• W2893500083 cites W2042815762 @default.
• W2893500083 cites W2048808551 @default.
• W2893500083 cites W2050909088 @default.
• W2893500083 cites W2055034530 @default.
• W2893500083 cites W2055432244 @default.
• W2893500083 cites W2055972373 @default.
• W2893500083 cites W2056200297 @default.
• W2893500083 cites W2061124896 @default.
• W2893500083 cites W2065192271 @default.
• W2893500083 cites W2077362497 @default.
• W2893500083 cites W2077924120 @default.
• W2893500083 cites W2138185621 @default.
• W2893500083 cites W2143168050 @default.
• W2893500083 cites W2179722802 @default.
• W2893500083 cites W2250713882 @default.
• W2893500083 cites W2275687520 @default.
• W2893500083 cites W2299705674 @default.
• W2893500083 cites W2470882271 @default.
• W2893500083 cites W2493092229 @default.
• W2893500083 cites W2512805835 @default.
• W2893500083 cites W2526579044 @default.
• W2893500083 cites W2566193558 @default.
• W2893500083 cites W2578919874 @default.
• W2893500083 cites W2594363254 @default.
• W2893500083 cites W2607313262 @default.
• W2893500083 cites W2617733786 @default.
• W2893500083 cites W2735340634 @default.
• W2893500083 cites W2750357613 @default.
• W2893500083 cites W2764323308 @default.
• W2893500083 cites W2791939349 @default.
• W2893500083 cites W2803345162 @default.
• W2893500083 doi "https://doi.org/10.1016/j.actbio.2018.09.035" @default.
• W2893500083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266636" @default.
• W2893500083 hasPublicationYear "2018" @default.
• W2893500083 type Work @default.
• W2893500083 sameAs 2893500083 @default.
• W2893500083 citedByCount "29" @default.
• W2893500083 countsByYear W28935000832019 @default.
• W2893500083 countsByYear W28935000832020 @default.
• W2893500083 countsByYear W28935000832021 @default.
• W2893500083 countsByYear W28935000832022 @default.
• W2893500083 countsByYear W28935000832023 @default.
• W2893500083 crossrefType "journal-article" @default.
• W2893500083 hasAuthorship W2893500083A5003272190 @default.
• W2893500083 hasAuthorship W2893500083A5006727515 @default.
• W2893500083 hasAuthorship W2893500083A5011035713 @default.
• W2893500083 hasAuthorship W2893500083A5020152050 @default.
• W2893500083 hasAuthorship W2893500083A5032110952 @default.
• W2893500083 hasAuthorship W2893500083A5082822722 @default.
• W2893500083 hasAuthorship W2893500083A5089822472 @default.
• W2893500083 hasBestOaLocation W28935000832 @default.
• W2893500083 hasConcept C127413603 @default.
• W2893500083 hasConcept C133495861 @default.
• W2893500083 hasConcept C147789679 @default.
• W2893500083 hasConcept C159985019 @default.
• W2893500083 hasConcept C171250308 @default.
• W2893500083 hasConcept C17525397 @default.
• W2893500083 hasConcept C185592680 @default.
• W2893500083 hasConcept C191897082 @default.
• W2893500083 hasConcept C191952053 @default.
• W2893500083 hasConcept C192562407 @default.
• W2893500083 hasConcept C2777230088 @default.
• W2893500083 hasConcept C2777232022 @default.
• W2893500083 hasConcept C2777529286 @default.
• W2893500083 hasConcept C2778414984 @default.
• W2893500083 hasConcept C42360764 @default.
• W2893500083 hasConcept C44228677 @default.
• W2893500083 hasConcept C49040817 @default.
• W2893500083 hasConcept C49853544 @default.
• W2893500083 hasConcept C521977710 @default.

• next