Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893500368> ?p ?o ?g. }
- W2893500368 abstract "Abstract Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca 2+ entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca 2+ influx through Ca 2+ release-activated Ca 2+ channels. Based on an in silico target prediction we identified multiple miR-34a-5p target genes within both pathways that are implicated in the balance between T-cell activation and apoptosis including ITPR2 , CAMLG , STIM1 , ORAI3 , RCAN1 , PPP3R1 , and NFATC4 . Functional analysis revealed a decrease in Ca 2+ activated calcineurin pathway activity measured by a reduced IL-2 secretion due to miR-34a-5p overexpression. Impacting SOCE and/or downstream calcineurin/NFAT signaling by miR-34a-5p offers a possible future approach to manipulate immune cells for clinical interventions." @default.
- W2893500368 created "2018-10-05" @default.
- W2893500368 creator A5016378595 @default.
- W2893500368 creator A5018232279 @default.
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- W2893500368 creator A5075631508 @default.
- W2893500368 creator A5085594740 @default.
- W2893500368 date "2018-09-27" @default.
- W2893500368 modified "2023-10-08" @default.
- W2893500368 title "Modulation of intracellular calcium signaling by microRNA-34a-5p" @default.
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