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• W2893500901 abstract ": Alveolar epithelial dysfunction induced by hypoxic stress plays a significant role in the pathological process of lung ischemia-reperfusion injury (IRI). Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in exerting protective immunomodulatory effects, thereby reducing airway inflammation in several pulmonary diseases. Aim: This study assesses the protective effects of MSC secretome from different cell sources, human bone marrow (BMSC) and adipose tissue (ADSC), in attenuating hypoxia-induced cellular stress and inflammation in pulmonary epithelial cells. Methods: Pulmonary epithelial cells, primary rat alveolar epithelial cells (AEC) and A549 cell line were pre-treated with BMSC, or ADSC conditioned medium (CM) and subjected to hypoxia for 24 h. Results: Both MSC-CM improved cell viability, reduced secretion of pro-inflammatory mediators and enhanced IL-10 anti-inflammatory cytokine production in hypoxic injured primary rat AECs. ADSC-CM reduced hypoxic cellular injury by mechanisms which include: inhibition of p38 MAPK phosphorylation and nuclear translocation of subunits in primary AECs. Both MSC-CM enhanced translocation of Bcl-2 to the nucleus, expression of cytoprotective glucose-regulated proteins (GRP) and restored matrix metalloproteinases (MMP) function, thereby promoting repair and cellular homeostasis, whereas inhibition of GRP chaperones was detrimental to cell survival. Conclusions: Elucidation of the protective mechanisms exerted by the MSC secretome is an essential step for maximizing the therapeutic effects, in addition to developing therapeutic targets-specific strategies for various pulmonary syndromes." @default.
• W2893500901 created "2018-10-05" @default.
• W2893500901 creator A5001565434 @default.
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• W2893500901 creator A5087900439 @default.
• W2893500901 creator A5091498476 @default.
• W2893500901 date "2018-09-30" @default.
• W2893500901 modified "2023-10-02" @default.
• W2893500901 title "Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury" @default.
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• W2893500901 doi "https://doi.org/10.3390/ijms19102996" @default.
• W2893500901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6212866" @default.
• W2893500901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30274394" @default.
• W2893500901 hasPublicationYear "2018" @default.
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