FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893501833> ?p ?o ?g. }

• W2893501833 endingPage "96.e6" @default.
• W2893501833 startingPage "88" @default.
• W2893501833 abstract "Purpose To examine clinical predictors of tumor mutational burden (TMB), to explore the association between TMB and DNA repair mutations, and to analyze TMB as a biomarker for response to immune checkpoint blockade in non–small-cell lung cancer. Patients and Methods TMB scores were determined retrospectively for 72 consecutive patients at our institution with next-generation sequencing comprehensive genomic profiling testing by Foundation Medicine. TMB scores were correlated with a number of clinical variables and presence of DNA repair mutations. Thirty-four patients were treated with anti–programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) therapies, and survival analyses based on TMB score were performed. In addition, tissue immunohistochemical analysis was performed for a subset of patients. Results History of smoking, but not other clinical variables, including prior treatment lines, stage of disease, and number of metastatic sites, predicted higher TMB score. Higher TMB score was significantly associated with greater number of DNA repair mutations. In the subset of patients treated with immune checkpoint blockade, higher TMB score significantly predicted overall survival, but not progression-free survival (hazard ratio = 0.10, P = .003; hazard ratio 1.1, P = .84, respectively). In a small subset of patients, PD-1/PD-L1 staining did not independently predict progression-free survival or overall survival. Conclusion Tissue TMB was significantly associated with smoking history and number of DNA repair mutations. TMB is a promising biomarker for response to anti–PD-1/PD-L1 therapy, with higher TMB score predicting longer overall survival." @default.
• W2893501833 created "2018-10-05" @default.
• W2893501833 creator A5032416166 @default.
• W2893501833 creator A5038847275 @default.
• W2893501833 creator A5053904756 @default.
• W2893501833 creator A5055165247 @default.
• W2893501833 creator A5061285204 @default.
• W2893501833 creator A5065305886 @default.
• W2893501833 creator A5073206138 @default.
• W2893501833 creator A5081588858 @default.
• W2893501833 date "2019-03-01" @default.
• W2893501833 modified "2023-10-13" @default.
• W2893501833 title "Association of Tumor Mutational Burden With DNA Repair Mutations and Response to Anti–PD-1/PD-L1 Therapy in Non–Small-Cell Lung Cancer" @default.
• W2893501833 cites W1531816655 @default.
• W2893501833 cites W1538419182 @default.
• W2893501833 cites W1940241680 @default.
• W2893501833 cites W1982488143 @default.
• W2893501833 cites W2011458181 @default.
• W2893501833 cites W2049553585 @default.
• W2893501833 cites W2096064375 @default.
• W2893501833 cites W2101653483 @default.
• W2893501833 cites W2104347254 @default.
• W2893501833 cites W2104885590 @default.
• W2893501833 cites W2107429737 @default.
• W2893501833 cites W2124427232 @default.
• W2893501833 cites W2131876608 @default.
• W2893501833 cites W2152061559 @default.
• W2893501833 cites W2175254188 @default.
• W2893501833 cites W2210073947 @default.
• W2893501833 cites W2265285917 @default.
• W2893501833 cites W2289712604 @default.
• W2893501833 cites W2300994822 @default.
• W2893501833 cites W2303680209 @default.
• W2893501833 cites W2312518973 @default.
• W2893501833 cites W2340636398 @default.
• W2893501833 cites W2340861895 @default.
• W2893501833 cites W2467321712 @default.
• W2893501833 cites W2504822853 @default.
• W2893501833 cites W2526607882 @default.
• W2893501833 cites W2527905628 @default.
• W2893501833 cites W2606495925 @default.
• W2893501833 cites W2622499649 @default.
• W2893501833 cites W2683488101 @default.
• W2893501833 cites W2747774814 @default.
• W2893501833 cites W2797675588 @default.
• W2893501833 cites W2947377238 @default.
• W2893501833 doi "https://doi.org/10.1016/j.cllc.2018.09.008" @default.
• W2893501833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30425022" @default.
• W2893501833 hasPublicationYear "2019" @default.
• W2893501833 type Work @default.
• W2893501833 sameAs 2893501833 @default.
• W2893501833 citedByCount "85" @default.
• W2893501833 countsByYear W28935018332019 @default.
• W2893501833 countsByYear W28935018332020 @default.
• W2893501833 countsByYear W28935018332021 @default.
• W2893501833 countsByYear W28935018332022 @default.
• W2893501833 countsByYear W28935018332023 @default.
• W2893501833 crossrefType "journal-article" @default.
• W2893501833 hasAuthorship W2893501833A5032416166 @default.
• W2893501833 hasAuthorship W2893501833A5038847275 @default.
• W2893501833 hasAuthorship W2893501833A5053904756 @default.
• W2893501833 hasAuthorship W2893501833A5055165247 @default.
• W2893501833 hasAuthorship W2893501833A5061285204 @default.
• W2893501833 hasAuthorship W2893501833A5065305886 @default.
• W2893501833 hasAuthorship W2893501833A5073206138 @default.
• W2893501833 hasAuthorship W2893501833A5081588858 @default.
• W2893501833 hasConcept C104317684 @default.
• W2893501833 hasConcept C121608353 @default.
• W2893501833 hasConcept C126322002 @default.
• W2893501833 hasConcept C134935766 @default.
• W2893501833 hasConcept C143998085 @default.
• W2893501833 hasConcept C170493617 @default.
• W2893501833 hasConcept C180754005 @default.
• W2893501833 hasConcept C207103383 @default.
• W2893501833 hasConcept C2776256026 @default.
• W2893501833 hasConcept C2777701055 @default.
• W2893501833 hasConcept C2778468042 @default.
• W2893501833 hasConcept C2779767149 @default.
• W2893501833 hasConcept C2780851360 @default.
• W2893501833 hasConcept C2781053074 @default.
• W2893501833 hasConcept C2781197716 @default.
• W2893501833 hasConcept C44249647 @default.
• W2893501833 hasConcept C50382708 @default.
• W2893501833 hasConcept C54355233 @default.
• W2893501833 hasConcept C61320498 @default.
• W2893501833 hasConcept C71924100 @default.
• W2893501833 hasConcept C86803240 @default.
• W2893501833 hasConceptScore W2893501833C104317684 @default.
• W2893501833 hasConceptScore W2893501833C121608353 @default.
• W2893501833 hasConceptScore W2893501833C126322002 @default.
• W2893501833 hasConceptScore W2893501833C134935766 @default.
• W2893501833 hasConceptScore W2893501833C143998085 @default.
• W2893501833 hasConceptScore W2893501833C170493617 @default.
• W2893501833 hasConceptScore W2893501833C180754005 @default.
• W2893501833 hasConceptScore W2893501833C207103383 @default.
• W2893501833 hasConceptScore W2893501833C2776256026 @default.
• W2893501833 hasConceptScore W2893501833C2777701055 @default.
• W2893501833 hasConceptScore W2893501833C2778468042 @default.

• next