FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893502248> ?p ?o ?g. }

• W2893502248 endingPage "41" @default.
• W2893502248 startingPage "25" @default.
• W2893502248 abstract "Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dietary intervention during pregnancy is an effective countermeasure. We utilized a well-established non-human primate model of chronic, maternal, Western-style diet induced obesity (OB-WSD) compared with mothers on a healthy control diet (CON) or a subset of OB-WSD mothers switched to the CON diet (diet reversal; OB-DR) prior to and for the duration of the next pregnancy. Fetuses were studied in the early 3rd trimester. Fetuses from OB-WSD mothers had higher circulating triglycerides (TGs) and lower arterial oxygenation suggesting hypoxemia, compared with fetuses from CON and OB-DR mothers. Hepatic TG content, oxidative stress (TBARs), and de novo lipogenic genes were increased in fetuses from OB-WSD compared with CON mothers. Fetuses from OB-DR mothers had lower lipogenic gene expression and TBARs yet persistently higher TGs. Metabolomic profiling of fetal liver and serum (umbilical artery) revealed distinct separation of CON and OB-WSD groups, and an intermediate phenotype in fetuses from OB-DR mothers. Pathway analysis identified decreased tricarboxylic acid cycle intermediates, increased amino acid (AA) metabolism and byproducts, and increased gluconeogenesis, suggesting an increased reliance on AA metabolism to meet energy needs in the liver of fetuses from OB-WSD mothers. Components in collagen synthesis, including serum protein 5-hydroxylysine and hepatic lysine and proline, were positively correlated with hepatic TGs and TBARs, suggesting early signs of fibrosis in livers from the OB-WSD group. Importantly, hepatic gluconeogenic and arginine related intermediates and serum levels of lactate, pyruvate, several AAs, and nucleotide intermediates were normalized in the OB-DR group. However, hepatic levels of CDP-choline and total ceramide levels remained high in fetuses from OB-DR mothers. Our data provide new metabolic evidence that, in addition to fetal hepatic steatosis, maternal WSD creates fetal hypoxemia and increases utilization of AAs for energy production and early activation of gluconeogenic pathways in the fetal liver. When combined with hyperlipidemia and limited antioxidant activity, the fetus suffers from hepatic oxidative stress and altered intracellular metabolism which can be improved with maternal diet intervention. Our data reinforce the concept that multiple “first hits” occur in the fetus prior to development of obesity and demonstrate new biomarkers with potential clinical implications for monitoring NAFLD risk in offspring." @default.
• W2893502248 created "2018-10-05" @default.
• W2893502248 creator A5005189935 @default.
• W2893502248 creator A5011610840 @default.
• W2893502248 creator A5043837910 @default.
• W2893502248 creator A5043916156 @default.
• W2893502248 creator A5045175167 @default.
• W2893502248 creator A5047037315 @default.
• W2893502248 creator A5049199951 @default.
• W2893502248 creator A5055697102 @default.
• W2893502248 creator A5056768064 @default.
• W2893502248 creator A5062138185 @default.
• W2893502248 creator A5062629731 @default.
• W2893502248 creator A5072159584 @default.
• W2893502248 creator A5086928894 @default.
• W2893502248 creator A5088249624 @default.
• W2893502248 creator A5090205493 @default.
• W2893502248 date "2018-12-01" @default.
• W2893502248 modified "2023-10-12" @default.
• W2893502248 title "Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates" @default.
• W2893502248 cites W1503760388 @default.
• W2893502248 cites W1586986973 @default.
• W2893502248 cites W1743581095 @default.
• W2893502248 cites W182337363 @default.
• W2893502248 cites W1916464334 @default.
• W2893502248 cites W1937575131 @default.
• W2893502248 cites W1967364108 @default.
• W2893502248 cites W1969470394 @default.
• W2893502248 cites W1971246106 @default.
• W2893502248 cites W1973021910 @default.
• W2893502248 cites W1981379568 @default.
• W2893502248 cites W1982545147 @default.
• W2893502248 cites W1983167131 @default.
• W2893502248 cites W1985236262 @default.
• W2893502248 cites W1988988264 @default.
• W2893502248 cites W1996577549 @default.
• W2893502248 cites W2000234289 @default.
• W2893502248 cites W2022319307 @default.
• W2893502248 cites W2026107145 @default.
• W2893502248 cites W2026244691 @default.
• W2893502248 cites W2028912233 @default.
• W2893502248 cites W2034714209 @default.
• W2893502248 cites W2036097574 @default.
• W2893502248 cites W2036735718 @default.
• W2893502248 cites W2037841634 @default.
• W2893502248 cites W2046910059 @default.
• W2893502248 cites W2047740187 @default.
• W2893502248 cites W2050830271 @default.
• W2893502248 cites W2059570482 @default.
• W2893502248 cites W2060006890 @default.
• W2893502248 cites W2063986174 @default.
• W2893502248 cites W2080554678 @default.
• W2893502248 cites W2087616058 @default.
• W2893502248 cites W2090154512 @default.
• W2893502248 cites W2097654747 @default.
• W2893502248 cites W2097662203 @default.
• W2893502248 cites W2098649954 @default.
• W2893502248 cites W2105772435 @default.
• W2893502248 cites W2106100463 @default.
• W2893502248 cites W2111370164 @default.
• W2893502248 cites W2116534551 @default.
• W2893502248 cites W2121699889 @default.
• W2893502248 cites W2128764301 @default.
• W2893502248 cites W2133985126 @default.
• W2893502248 cites W2139351004 @default.
• W2893502248 cites W2141378847 @default.
• W2893502248 cites W2149917889 @default.
• W2893502248 cites W2155686141 @default.
• W2893502248 cites W2159583302 @default.
• W2893502248 cites W2165042715 @default.
• W2893502248 cites W2175091172 @default.
• W2893502248 cites W2230222215 @default.
• W2893502248 cites W2251125181 @default.
• W2893502248 cites W2275684152 @default.
• W2893502248 cites W2336816986 @default.
• W2893502248 cites W2337080773 @default.
• W2893502248 cites W2341568598 @default.
• W2893502248 cites W2362439486 @default.
• W2893502248 cites W2424681749 @default.
• W2893502248 cites W2536908951 @default.
• W2893502248 cites W2543316248 @default.
• W2893502248 cites W2548952244 @default.
• W2893502248 cites W2561898058 @default.
• W2893502248 cites W2563751900 @default.
• W2893502248 cites W2564454911 @default.
• W2893502248 cites W2586570290 @default.
• W2893502248 cites W2587940603 @default.
• W2893502248 cites W2588250733 @default.
• W2893502248 cites W2598420687 @default.
• W2893502248 cites W2612023289 @default.
• W2893502248 cites W2619938137 @default.
• W2893502248 cites W2633654758 @default.
• W2893502248 cites W2646212403 @default.
• W2893502248 cites W2738023565 @default.
• W2893502248 cites W2739138660 @default.
• W2893502248 cites W2765162408 @default.
• W2893502248 cites W2777541288 @default.
• W2893502248 cites W2785427385 @default.

• next