Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893502543> ?p ?o ?g. }
- W2893502543 abstract "Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network changes is elusive. Aiming to trace specifically the network controlled by exon-IV and -VI derived BDNF during activity-dependent plasticity changes, we generated a transgenic reporter mouse for BDNF- live-exon- visualization (BLEV), in which expression of Bdnf exon-IV and -VI can be visualized by co-expression of CFP and YFP. CFP and YFP expression was differentially activated and targeted in cell lines, primary cultures and BLEV reporter mice without interfering with BDNF protein synthesis. CFP and YFP expression, moreover, overlapped with BDNF protein expression in defined hippocampal neuronal, glial and vascular locations in vivo. So far, activity-dependent BDNF cannot be explicitly monitored independent of basal BDNF levels. The BLEV reporter mouse therefore provides a new model, which can be used to test whether stimulus-induced activity-dependent changes in BDNF expression are instrumental for long-lasting plasticity modifications." @default.
- W2893502543 created "2018-10-05" @default.
- W2893502543 creator A5003455470 @default.
- W2893502543 creator A5008007575 @default.
- W2893502543 creator A5008529621 @default.
- W2893502543 creator A5009119729 @default.
- W2893502543 creator A5012338889 @default.
- W2893502543 creator A5029675468 @default.
- W2893502543 creator A5034686959 @default.
- W2893502543 creator A5037985730 @default.
- W2893502543 creator A5046552100 @default.
- W2893502543 creator A5048607283 @default.
- W2893502543 creator A5051452708 @default.
- W2893502543 creator A5053785057 @default.
- W2893502543 creator A5057073900 @default.
- W2893502543 creator A5065387386 @default.
- W2893502543 creator A5069954594 @default.
- W2893502543 creator A5076243701 @default.
- W2893502543 creator A5077225109 @default.
- W2893502543 creator A5087372330 @default.
- W2893502543 creator A5087533254 @default.
- W2893502543 creator A5087932640 @default.
- W2893502543 creator A5089917194 @default.
- W2893502543 date "2018-09-27" @default.
- W2893502543 modified "2023-10-12" @default.
- W2893502543 title "BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo" @default.
- W2893502543 cites W1505372769 @default.
- W2893502543 cites W1527035699 @default.
- W2893502543 cites W1539810844 @default.
- W2893502543 cites W1597356000 @default.
- W2893502543 cites W1608213943 @default.
- W2893502543 cites W1830398839 @default.
- W2893502543 cites W1851140426 @default.
- W2893502543 cites W1857015666 @default.
- W2893502543 cites W1918279387 @default.
- W2893502543 cites W1918776755 @default.
- W2893502543 cites W1954362343 @default.
- W2893502543 cites W1964326082 @default.
- W2893502543 cites W1964741617 @default.
- W2893502543 cites W1965116070 @default.
- W2893502543 cites W1966595105 @default.
- W2893502543 cites W1966785609 @default.
- W2893502543 cites W1971110013 @default.
- W2893502543 cites W1973883693 @default.
- W2893502543 cites W1974705547 @default.
- W2893502543 cites W1987436202 @default.
- W2893502543 cites W1989976072 @default.
- W2893502543 cites W1992529363 @default.
- W2893502543 cites W1993870556 @default.
- W2893502543 cites W2000209446 @default.
- W2893502543 cites W2000523742 @default.
- W2893502543 cites W2002637584 @default.
- W2893502543 cites W2003665687 @default.
- W2893502543 cites W2004632368 @default.
- W2893502543 cites W2005215351 @default.
- W2893502543 cites W2006837481 @default.
- W2893502543 cites W2006934911 @default.
- W2893502543 cites W2010050518 @default.
- W2893502543 cites W2012825989 @default.
- W2893502543 cites W2013558874 @default.
- W2893502543 cites W2015082850 @default.
- W2893502543 cites W2017587146 @default.
- W2893502543 cites W2030933765 @default.
- W2893502543 cites W2031130098 @default.
- W2893502543 cites W2033026245 @default.
- W2893502543 cites W2034843904 @default.
- W2893502543 cites W2036543911 @default.
- W2893502543 cites W2037462628 @default.
- W2893502543 cites W2038122755 @default.
- W2893502543 cites W2047225543 @default.
- W2893502543 cites W2048339036 @default.
- W2893502543 cites W2055350470 @default.
- W2893502543 cites W2056663744 @default.
- W2893502543 cites W205881385 @default.
- W2893502543 cites W2058861807 @default.
- W2893502543 cites W2059856205 @default.
- W2893502543 cites W2060854925 @default.
- W2893502543 cites W2064071741 @default.
- W2893502543 cites W2064636593 @default.
- W2893502543 cites W2066386560 @default.
- W2893502543 cites W2066488827 @default.
- W2893502543 cites W2070261165 @default.
- W2893502543 cites W2075117930 @default.
- W2893502543 cites W2078098099 @default.
- W2893502543 cites W2078740239 @default.
- W2893502543 cites W2078789553 @default.
- W2893502543 cites W2079338662 @default.
- W2893502543 cites W2079472132 @default.
- W2893502543 cites W2080428182 @default.
- W2893502543 cites W2081980464 @default.
- W2893502543 cites W2083547018 @default.
- W2893502543 cites W2086282269 @default.
- W2893502543 cites W2086364410 @default.
- W2893502543 cites W2086831139 @default.
- W2893502543 cites W2087082832 @default.
- W2893502543 cites W2089059131 @default.
- W2893502543 cites W2089448293 @default.
- W2893502543 cites W2093545276 @default.
- W2893502543 cites W2094376682 @default.
- W2893502543 cites W2096456994 @default.