Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893502788> ?p ?o ?g. }
- W2893502788 abstract "Abstract Melatonin is an immune modulator that displays both pro‐ and anti‐inflammatory properties. Proinflammatory actions, which are well documented by many studies in isolated cells or leukocyte‐derived cell lines, can be assumed to enhance the resistance against pathogens. However, they can be detrimental in autoimmune diseases. Anti‐inflammatory actions are of particular medicinal interest, because they are observed in high‐grade inflammation such as sepsis, ischemia/reperfusion, and brain injury, and also in low‐grade inflammation during aging and in neurodegenerative diseases. The mechanisms contributing to anti‐inflammatory effects are manifold and comprise various pathways of secondary signaling. These include numerous antioxidant effects, downregulation of inducible and inhibition of neuronal NO synthases, downregulation of cyclooxygenase‐2, inhibition of high‐mobility group box‐1 signaling and toll‐like receptor‐4 activation, prevention of inflammasome NLRP3 activation, inhibition of NF‐κB activation and upregulation of nuclear factor erythroid 2‐related factor 2 (Nrf2). These effects are also reflected by downregulation of proinflammatory and upregulation of anti‐inflammatory cytokines. Proinflammatory actions of amyloid‐β peptides are reduced by enhancing α‐secretase and inhibition of β‐ and γ‐secretases. A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin (mTOR) and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2 . The conclusion on a partial mediation by SIRT1 is supported by repeatedly observed inhibitions of melatonin effects by sirtuin inhibitors or knockdown." @default.
- W2893502788 created "2018-10-05" @default.
- W2893502788 creator A5034115336 @default.
- W2893502788 date "2018-10-12" @default.
- W2893502788 modified "2023-10-11" @default.
- W2893502788 title "Melatonin and inflammation—Story of a double‐edged blade" @default.
- W2893502788 cites W1279301897 @default.
- W2893502788 cites W1492774743 @default.
- W2893502788 cites W1496541446 @default.
- W2893502788 cites W1500479217 @default.
- W2893502788 cites W1526473725 @default.
- W2893502788 cites W1554079895 @default.
- W2893502788 cites W1564022474 @default.
- W2893502788 cites W1581691059 @default.
- W2893502788 cites W1593139023 @default.
- W2893502788 cites W1667397546 @default.
- W2893502788 cites W1761076309 @default.
- W2893502788 cites W1894030112 @default.
- W2893502788 cites W1905068017 @default.
- W2893502788 cites W1913186869 @default.
- W2893502788 cites W1926960484 @default.
- W2893502788 cites W1947214230 @default.
- W2893502788 cites W1954154747 @default.
- W2893502788 cites W1964187078 @default.
- W2893502788 cites W1965054947 @default.
- W2893502788 cites W1965591661 @default.
- W2893502788 cites W1966006827 @default.
- W2893502788 cites W1966167609 @default.
- W2893502788 cites W1968193057 @default.
- W2893502788 cites W1969199763 @default.
- W2893502788 cites W1974407486 @default.
- W2893502788 cites W1974622875 @default.
- W2893502788 cites W1975364680 @default.
- W2893502788 cites W1977152010 @default.
- W2893502788 cites W1978537670 @default.
- W2893502788 cites W1978650811 @default.
- W2893502788 cites W1979196829 @default.
- W2893502788 cites W1979572698 @default.
- W2893502788 cites W1981359936 @default.
- W2893502788 cites W1982224607 @default.
- W2893502788 cites W1984203151 @default.
- W2893502788 cites W1984663488 @default.
- W2893502788 cites W1985190814 @default.
- W2893502788 cites W1985848312 @default.
- W2893502788 cites W1985982692 @default.
- W2893502788 cites W1986615746 @default.
- W2893502788 cites W1987268517 @default.
- W2893502788 cites W1987699071 @default.
- W2893502788 cites W1988453520 @default.
- W2893502788 cites W1988934115 @default.
- W2893502788 cites W1989065114 @default.
- W2893502788 cites W1989496648 @default.
- W2893502788 cites W1991250134 @default.
- W2893502788 cites W1992507257 @default.
- W2893502788 cites W1992610922 @default.
- W2893502788 cites W1994154499 @default.
- W2893502788 cites W1998713395 @default.
- W2893502788 cites W2000184770 @default.
- W2893502788 cites W2000347605 @default.
- W2893502788 cites W2001465332 @default.
- W2893502788 cites W2002706824 @default.
- W2893502788 cites W2005441052 @default.
- W2893502788 cites W2005499201 @default.
- W2893502788 cites W2006761570 @default.
- W2893502788 cites W2006858989 @default.
- W2893502788 cites W2007647292 @default.
- W2893502788 cites W2007671795 @default.
- W2893502788 cites W2009745241 @default.
- W2893502788 cites W2011074122 @default.
- W2893502788 cites W2011176180 @default.
- W2893502788 cites W2012661110 @default.
- W2893502788 cites W2015542694 @default.
- W2893502788 cites W2017824629 @default.
- W2893502788 cites W2019084544 @default.
- W2893502788 cites W2019319908 @default.
- W2893502788 cites W2021399303 @default.
- W2893502788 cites W2021980639 @default.
- W2893502788 cites W2023183146 @default.
- W2893502788 cites W2023514845 @default.
- W2893502788 cites W2025675177 @default.
- W2893502788 cites W2026744070 @default.
- W2893502788 cites W2027764072 @default.
- W2893502788 cites W2027999012 @default.
- W2893502788 cites W2029356978 @default.
- W2893502788 cites W2029535496 @default.
- W2893502788 cites W2030761958 @default.
- W2893502788 cites W2031509851 @default.
- W2893502788 cites W2031780759 @default.
- W2893502788 cites W2032779870 @default.
- W2893502788 cites W2033147224 @default.
- W2893502788 cites W2034133264 @default.
- W2893502788 cites W2034346924 @default.
- W2893502788 cites W2035352223 @default.
- W2893502788 cites W2036691084 @default.
- W2893502788 cites W2036762936 @default.
- W2893502788 cites W2036949761 @default.
- W2893502788 cites W2038870006 @default.
- W2893502788 cites W2039864897 @default.
- W2893502788 cites W2041887179 @default.
- W2893502788 cites W2042815338 @default.