Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893505137> ?p ?o ?g. }
- W2893505137 abstract "Microglia are ramified cells that exhibit highly motile processes, which continuously survey the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia have long been recognized as a crucial player in generating and maintaining inflammatory responses in the CNS, now it has become clear, that their function are much more diverse, particularly in the healthy brain. The innate immune response and phagocytosis represent only a little segment of microglia functional repertoire that also includes maintenance of biochemical homeostasis, neuronal circuit maturation during development and experience-dependent remodeling of neuronal circuits in the adult brain. Being equipped by numerous receptors and cell surface molecules microglia can perform bidirectional interactions with other cell types in the CNS. There is accumulating evidence showing that neurons inform microglia about their status and thus are capable of controlling microglial activation and motility while microglia also modulate neuronal activities. This review addresses the topic: how microglia communicate with other cell types in the brain, including fractalkine signaling, secreted soluble factors and extracellular vesicles. We summarize the current state of knowledge of physiological role and function of microglia during brain development and in the mature brain and further highlight microglial contribution to brain pathologies such as Alzheimer's and Parkinson's disease, brain ischemia, traumatic brain injury, brain tumor as well as neuropsychiatric diseases (depression, bipolar disorder, and schizophrenia)." @default.
- W2893505137 created "2018-10-05" @default.
- W2893505137 creator A5006171499 @default.
- W2893505137 creator A5043870831 @default.
- W2893505137 creator A5048629425 @default.
- W2893505137 creator A5067564154 @default.
- W2893505137 date "2018-09-27" @default.
- W2893505137 modified "2023-10-16" @default.
- W2893505137 title "Bidirectional Microglia–Neuron Communication in Health and Disease" @default.
- W2893505137 cites W1179759088 @default.
- W2893505137 cites W1506672302 @default.
- W2893505137 cites W1519245788 @default.
- W2893505137 cites W1528120845 @default.
- W2893505137 cites W1530763983 @default.
- W2893505137 cites W1534792373 @default.
- W2893505137 cites W1537407495 @default.
- W2893505137 cites W1548862642 @default.
- W2893505137 cites W1557065109 @default.
- W2893505137 cites W1562902980 @default.
- W2893505137 cites W1575000707 @default.
- W2893505137 cites W1575263086 @default.
- W2893505137 cites W1599691548 @default.
- W2893505137 cites W1600123087 @default.
- W2893505137 cites W1607819524 @default.
- W2893505137 cites W1651376769 @default.
- W2893505137 cites W1716975759 @default.
- W2893505137 cites W175813982 @default.
- W2893505137 cites W1856731619 @default.
- W2893505137 cites W1892074666 @default.
- W2893505137 cites W1897415252 @default.
- W2893505137 cites W1910163729 @default.
- W2893505137 cites W1937405158 @default.
- W2893505137 cites W1942784841 @default.
- W2893505137 cites W1944546979 @default.
- W2893505137 cites W1949203224 @default.
- W2893505137 cites W1963664876 @default.
- W2893505137 cites W1965278163 @default.
- W2893505137 cites W1966391749 @default.
- W2893505137 cites W1967329842 @default.
- W2893505137 cites W1967375281 @default.
- W2893505137 cites W1967383957 @default.
- W2893505137 cites W1968597551 @default.
- W2893505137 cites W1969126678 @default.
- W2893505137 cites W1970345181 @default.
- W2893505137 cites W1970435912 @default.
- W2893505137 cites W1970796628 @default.
- W2893505137 cites W1971969390 @default.
- W2893505137 cites W1972307586 @default.
- W2893505137 cites W1972988703 @default.
- W2893505137 cites W1973125755 @default.
- W2893505137 cites W1973187560 @default.
- W2893505137 cites W1974003946 @default.
- W2893505137 cites W1974077164 @default.
- W2893505137 cites W1975021551 @default.
- W2893505137 cites W1977350565 @default.
- W2893505137 cites W1978238793 @default.
- W2893505137 cites W1980485314 @default.
- W2893505137 cites W1980789245 @default.
- W2893505137 cites W1983417696 @default.
- W2893505137 cites W1984103995 @default.
- W2893505137 cites W1984115097 @default.
- W2893505137 cites W1985925098 @default.
- W2893505137 cites W1986611577 @default.
- W2893505137 cites W1988889092 @default.
- W2893505137 cites W1989020899 @default.
- W2893505137 cites W1990078228 @default.
- W2893505137 cites W1990140740 @default.
- W2893505137 cites W1990151307 @default.
- W2893505137 cites W1991238912 @default.
- W2893505137 cites W1991288075 @default.
- W2893505137 cites W1991805788 @default.
- W2893505137 cites W1991934654 @default.
- W2893505137 cites W1992352812 @default.
- W2893505137 cites W1993374742 @default.
- W2893505137 cites W1993976394 @default.
- W2893505137 cites W1994155291 @default.
- W2893505137 cites W1994201230 @default.
- W2893505137 cites W1994511844 @default.
- W2893505137 cites W1995374504 @default.
- W2893505137 cites W1996024251 @default.
- W2893505137 cites W1996055705 @default.
- W2893505137 cites W1996219630 @default.
- W2893505137 cites W1996256952 @default.
- W2893505137 cites W1996605253 @default.
- W2893505137 cites W1997602206 @default.
- W2893505137 cites W1998628114 @default.
- W2893505137 cites W1999069947 @default.
- W2893505137 cites W1999363307 @default.
- W2893505137 cites W1999952543 @default.
- W2893505137 cites W2000093679 @default.
- W2893505137 cites W2002150570 @default.
- W2893505137 cites W2003215052 @default.
- W2893505137 cites W2003674452 @default.
- W2893505137 cites W2004492484 @default.
- W2893505137 cites W2006374396 @default.
- W2893505137 cites W2006711955 @default.
- W2893505137 cites W2007106590 @default.
- W2893505137 cites W2007287932 @default.
- W2893505137 cites W2007618030 @default.
- W2893505137 cites W2007724660 @default.