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- W2893509594 abstract "Acanthosis nigricans is characterized by velvety, brownish blackpigmentation of flexural areas. Acanthosis nigricans is considered as a marker ofinternal diseases like insulin resistance, diabetes, hypothyroidism, polycysticovarian disease and rarely internal malignancies.AIMS AND OBJECTIVESThe study aims to1) Study the epidemiology of Acanthosis Nigricans2) Find out associated common endocrinological diseases3) Compare the effectiveness of various topical therapeutic modalitiesMATERIALS AND METHODSHundred patients of acanthosis nigricans were selected. Relevantinvestigations like blood sugar, fasting lipid profile, thyroid profile and ultrasoundabdomen were done. Body mass index was calculated for all patients. Patientswere then randomly divided into 5 treatment groups of 20 patients each. Group Areceiving Topical 0.05% tretinoin, Group B receiving topical 0.005% calcipotriol,Group C receiving topical triple combination cream containing Hydroquinone 2%,tretinoin 0.05% and Fluocinolone acetonide 0.01%, Group D treated with 35%Trichloroacetic acid peel and Group E treated with 50% Glycolic acid peel.OBSERVATION AND RESULTSAcanthosis nigricans was more common in females than males with aratio of 2.22: 1 and the mean age was 22.24 years. Nearly seventy percent ofpatients had abnormal body mass index. Acrochordon was the most commonassociated dermatological finding. Diabetes was the most common endocrineabnormality present in 41% of patients followed by dyslipidemia andhypothyroidism. Nearly 19% of the female patients had polycystic ovarian disease.Chemical peeling with trichloro acetic acid had the maximum response percentageof 75% and topical calcipotriol had the least response percentage of 25%.CONCLUSIONIn our study age, sex and site distribution were in concurrence with theprevious studies. Topical treatment need to be given for longer period withsimultaneous treatment of endocrine disorders and obesity for better results." @default.
- W2893509594 created "2018-10-05" @default.
- W2893509594 creator A5033163472 @default.
- W2893509594 date "2016-04-01" @default.
- W2893509594 modified "2023-09-27" @default.
- W2893509594 title "Acanthosis Nigricans: A Clinicoepidemiological and Therapeutic comparison study" @default.
- W2893509594 hasPublicationYear "2016" @default.
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