FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893516826> ?p ?o ?g. }

• W2893516826 abstract "There is controversy around the prescription of adjunct corticosteroids in patients with fluid-refractory septic shock, and studies provide mixed results, showing benefit, no benefit, and harm. Traditional means for evaluating whether a patient receives corticosteroids relied on anecdotal experience or measurement of serum cortisol production following stimulation. We set out to measure both serum cortisol and the intracellular signaling receptor for cortisol, the glucocorticoid receptor (GCR), in this group of patients. We enrolled pediatric patients admitted to the pediatric intensive care unit with a diagnosis of systemic inflammatory response syndrome (SIRS), sepsis, or septic shock as well as healthy controls. We measured serum cortisol concentration and GCR expression by flow cytometry in peripheral blood leukocytes on the day of admission and day 3. We enrolled 164 patients for analysis. There was no difference between GCR expression comparing SIRS, sepsis, and septic shock. When all patients with septic shock were compared, those patients with a complicated course, defined as two or more organ failures at day 7 or death by day 28, had lower expression of GCR in all peripheral blood leukocytes. Further analysis suggested that patients with the combination of low GCR and high serum cortisol had higher rates of complicated course (75%) compared with the other three possible combinations of GCR and cortisol levels: low GCR and low cortisol (33%), high GCR and high cortisol (33%), and high GCR and low cortisol (13%; P <0.05). We show that decreased expression of the GCR correlated with poor outcome from septic shock, particularly in those patients with high serum cortisol. This is consistent with findings from transcriptional studies showing that downregulation of GCR signaling genes portends worse outcome." @default.
• W2893516826 created "2018-10-05" @default.
• W2893516826 creator A5007396226 @default.
• W2893516826 creator A5020609229 @default.
• W2893516826 creator A5082112042 @default.
• W2893516826 date "2018-09-29" @default.
• W2893516826 modified "2023-09-30" @default.
• W2893516826 title "The glucocorticoid receptor and cortisol levels in pediatric septic shock" @default.
• W2893516826 cites W1559226045 @default.
• W2893516826 cites W1981722357 @default.
• W2893516826 cites W1998647895 @default.
• W2893516826 cites W2049474866 @default.
• W2893516826 cites W2054469201 @default.
• W2893516826 cites W2059130611 @default.
• W2893516826 cites W2060254943 @default.
• W2893516826 cites W2069200792 @default.
• W2893516826 cites W2076590961 @default.
• W2893516826 cites W2087481810 @default.
• W2893516826 cites W2091584908 @default.
• W2893516826 cites W2098558453 @default.
• W2893516826 cites W2113535256 @default.
• W2893516826 cites W2135993691 @default.
• W2893516826 cites W2142503879 @default.
• W2893516826 cites W2156828749 @default.
• W2893516826 cites W2185548361 @default.
• W2893516826 cites W2293709786 @default.
• W2893516826 cites W2550507245 @default.
• W2893516826 cites W2581605534 @default.
• W2893516826 cites W2750498846 @default.
• W2893516826 cites W2775458198 @default.
• W2893516826 cites W2784412824 @default.
• W2893516826 cites W2794125559 @default.
• W2893516826 cites W3023757607 @default.
• W2893516826 cites W3045454797 @default.
• W2893516826 doi "https://doi.org/10.1186/s13054-018-2177-8" @default.
• W2893516826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162875" @default.
• W2893516826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268145" @default.
• W2893516826 hasPublicationYear "2018" @default.
• W2893516826 type Work @default.
• W2893516826 sameAs 2893516826 @default.
• W2893516826 citedByCount "16" @default.
• W2893516826 countsByYear W28935168262019 @default.
• W2893516826 countsByYear W28935168262020 @default.
• W2893516826 countsByYear W28935168262021 @default.
• W2893516826 countsByYear W28935168262022 @default.
• W2893516826 countsByYear W28935168262023 @default.
• W2893516826 crossrefType "journal-article" @default.
• W2893516826 hasAuthorship W2893516826A5007396226 @default.
• W2893516826 hasAuthorship W2893516826A5020609229 @default.
• W2893516826 hasAuthorship W2893516826A5082112042 @default.
• W2893516826 hasBestOaLocation W28935168261 @default.
• W2893516826 hasConcept C126322002 @default.
• W2893516826 hasConcept C177713679 @default.
• W2893516826 hasConcept C2776376669 @default.
• W2893516826 hasConcept C2777628635 @default.
• W2893516826 hasConcept C2778129406 @default.
• W2893516826 hasConcept C2778384902 @default.
• W2893516826 hasConcept C2778426790 @default.
• W2893516826 hasConcept C2778709874 @default.
• W2893516826 hasConcept C2780841215 @default.
• W2893516826 hasConcept C2781090800 @default.
• W2893516826 hasConcept C2781300812 @default.
• W2893516826 hasConcept C2987404301 @default.
• W2893516826 hasConcept C59493245 @default.
• W2893516826 hasConcept C71924100 @default.
• W2893516826 hasConceptScore W2893516826C126322002 @default.
• W2893516826 hasConceptScore W2893516826C177713679 @default.
• W2893516826 hasConceptScore W2893516826C2776376669 @default.
• W2893516826 hasConceptScore W2893516826C2777628635 @default.
• W2893516826 hasConceptScore W2893516826C2778129406 @default.
• W2893516826 hasConceptScore W2893516826C2778384902 @default.
• W2893516826 hasConceptScore W2893516826C2778426790 @default.
• W2893516826 hasConceptScore W2893516826C2778709874 @default.
• W2893516826 hasConceptScore W2893516826C2780841215 @default.
• W2893516826 hasConceptScore W2893516826C2781090800 @default.
• W2893516826 hasConceptScore W2893516826C2781300812 @default.
• W2893516826 hasConceptScore W2893516826C2987404301 @default.
• W2893516826 hasConceptScore W2893516826C59493245 @default.
• W2893516826 hasConceptScore W2893516826C71924100 @default.
• W2893516826 hasFunder F4320337354 @default.
• W2893516826 hasIssue "1" @default.
• W2893516826 hasLocation W28935168261 @default.
• W2893516826 hasLocation W28935168262 @default.
• W2893516826 hasLocation W28935168263 @default.
• W2893516826 hasLocation W28935168264 @default.
• W2893516826 hasLocation W28935168265 @default.
• W2893516826 hasOpenAccess W2893516826 @default.
• W2893516826 hasPrimaryLocation W28935168261 @default.
• W2893516826 hasRelatedWork W1967031337 @default.
• W2893516826 hasRelatedWork W2020861620 @default.
• W2893516826 hasRelatedWork W2294851047 @default.
• W2893516826 hasRelatedWork W2748611861 @default.
• W2893516826 hasRelatedWork W2893516826 @default.
• W2893516826 hasRelatedWork W2898786944 @default.
• W2893516826 hasRelatedWork W3032495639 @default.
• W2893516826 hasRelatedWork W3203503521 @default.
• W2893516826 hasRelatedWork W4322217346 @default.
• W2893516826 hasRelatedWork W3092478897 @default.
• W2893516826 hasVolume "22" @default.
• W2893516826 isParatext "false" @default.

• next