FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893518023> ?p ?o ?g. }

• W2893518023 endingPage "1270" @default.
• W2893518023 startingPage "1249" @default.
• W2893518023 abstract "Protein kinases are involved in various cellular functions. About 2% of the human genome encodes for protein kinases. Dysregulation of protein kinases is implicated in various processes of carcinogenesis. The advent of protein kinase inhibitors in cancer therapy has led to a paradigm shift in cancer therapy. Several protein kinase inhibitors have been approved by FDA in the last few decades. Areas covered: This article provides a review of the FDA approved protein kinase inhibitors as of December 2017 for the well-known oncogenic protein kinases. A list of FDA approved protein kinase inhibitors and their FDA approved clinical indications were cataloged. The role of the respective oncogenic protein kinases in carcinogenesis and cancer progression and the relevant landmark clinical trials of respective protein kinase inhibitors leading up to the FDA approval were PubMed searched and discussed. Expert commentary: Further understanding of the molecular origin of various cancers would help identify new targets. Use of biomarker profiling might select the patient population that would benefit better from kinase inhibitors. Clinical trials should be designed to identify the appropriate sequence of the available kinase inhibitors. It would prove to be useful to test these drugs in the adjuvant setting." @default.
• W2893518023 created "2018-10-05" @default.
• W2893518023 creator A5035164790 @default.
• W2893518023 creator A5051380025 @default.
• W2893518023 date "2018-10-09" @default.
• W2893518023 modified "2023-10-17" @default.
• W2893518023 title "A comprehensive review of protein kinase inhibitors for cancer therapy" @default.
• W2893518023 cites W1523946531 @default.
• W2893518023 cites W1587979812 @default.
• W2893518023 cites W1639582946 @default.
• W2893518023 cites W1679250118 @default.
• W2893518023 cites W1843886919 @default.
• W2893518023 cites W1965370740 @default.
• W2893518023 cites W1967792499 @default.
• W2893518023 cites W1968530572 @default.
• W2893518023 cites W1969328947 @default.
• W2893518023 cites W1971837077 @default.
• W2893518023 cites W1974091059 @default.
• W2893518023 cites W1978173977 @default.
• W2893518023 cites W1980568348 @default.
• W2893518023 cites W1983999811 @default.
• W2893518023 cites W1986845952 @default.
• W2893518023 cites W1989604472 @default.
• W2893518023 cites W1990030298 @default.
• W2893518023 cites W1994193851 @default.
• W2893518023 cites W1999330214 @default.
• W2893518023 cites W199978508 @default.
• W2893518023 cites W1999966467 @default.
• W2893518023 cites W2004771750 @default.
• W2893518023 cites W2007256480 @default.
• W2893518023 cites W2011474502 @default.
• W2893518023 cites W2014467084 @default.
• W2893518023 cites W2016456933 @default.
• W2893518023 cites W2019216438 @default.
• W2893518023 cites W2023952988 @default.
• W2893518023 cites W2026951964 @default.
• W2893518023 cites W2028959752 @default.
• W2893518023 cites W2030205108 @default.
• W2893518023 cites W2035982599 @default.
• W2893518023 cites W2038161969 @default.
• W2893518023 cites W2039155298 @default.
• W2893518023 cites W2043696829 @default.
• W2893518023 cites W2046507292 @default.
• W2893518023 cites W2049145190 @default.
• W2893518023 cites W2050249255 @default.
• W2893518023 cites W2052923507 @default.
• W2893518023 cites W2054686043 @default.
• W2893518023 cites W2054917860 @default.
• W2893518023 cites W2055402151 @default.
• W2893518023 cites W2057206328 @default.
• W2893518023 cites W2057272791 @default.
• W2893518023 cites W2059150276 @default.
• W2893518023 cites W2059705970 @default.
• W2893518023 cites W2061440903 @default.
• W2893518023 cites W2065799563 @default.
• W2893518023 cites W2066564017 @default.
• W2893518023 cites W2080686146 @default.
• W2893518023 cites W2090029719 @default.
• W2893518023 cites W2090549486 @default.
• W2893518023 cites W2092606584 @default.
• W2893518023 cites W2096003848 @default.
• W2893518023 cites W2096387850 @default.
• W2893518023 cites W2099530756 @default.
• W2893518023 cites W2103827225 @default.
• W2893518023 cites W2104694028 @default.
• W2893518023 cites W2105388112 @default.
• W2893518023 cites W2107268345 @default.
• W2893518023 cites W2108036229 @default.
• W2893518023 cites W2108206643 @default.
• W2893518023 cites W2109678955 @default.
• W2893518023 cites W2110444464 @default.
• W2893518023 cites W2110648386 @default.
• W2893518023 cites W2111404068 @default.
• W2893518023 cites W2111662961 @default.
• W2893518023 cites W2113764179 @default.
• W2893518023 cites W2115351357 @default.
• W2893518023 cites W2115966993 @default.
• W2893518023 cites W2116153687 @default.
• W2893518023 cites W2116922255 @default.
• W2893518023 cites W2119501407 @default.
• W2893518023 cites W2121545342 @default.
• W2893518023 cites W2121743767 @default.
• W2893518023 cites W2122395736 @default.
• W2893518023 cites W2122956665 @default.
• W2893518023 cites W2124196948 @default.
• W2893518023 cites W2125760261 @default.
• W2893518023 cites W2125916043 @default.
• W2893518023 cites W2128542677 @default.
• W2893518023 cites W2130864403 @default.
• W2893518023 cites W2132870547 @default.
• W2893518023 cites W2133192145 @default.
• W2893518023 cites W2133347001 @default.
• W2893518023 cites W2133503038 @default.
• W2893518023 cites W2134131507 @default.
• W2893518023 cites W2134471382 @default.
• W2893518023 cites W2134861285 @default.
• W2893518023 cites W2134978639 @default.
• W2893518023 cites W2136065656 @default.

• next