Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893521651> ?p ?o ?g. }
- W2893521651 endingPage "2109" @default.
- W2893521651 startingPage "2101" @default.
- W2893521651 abstract "Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late replication intermediates induced by replication stress, and DNA linkages at telomeres. Recently, it was reported that DNA intertwinements generated by homologous recombination give rise to a new class of UFBs, which have been termed homologous recombination ultrafine bridges (HR-UFBs). HR-UFBs are decorated with PICH and BLM in anaphase, and are subsequently converted to RPA-coated, single-stranded DNA bridges. Breakage of these sister chromatid entanglements leads to DNA damage that can be repaired by non-homologous end joining in the next cell cycle, but the potential consequences include DNA rearrangements, chromosome translocations and fusions. Visualisation of these HR-UFBs, and knowledge of how they arise, provides a molecular basis to explain how upregulation of homologous recombination or failure to resolve recombination intermediates leads to the development of chromosomal instability observed in certain cancers." @default.
- W2893521651 created "2018-10-05" @default.
- W2893521651 creator A5054117046 @default.
- W2893521651 creator A5081530748 @default.
- W2893521651 date "2018-09-02" @default.
- W2893521651 modified "2023-10-05" @default.
- W2893521651 title "A new class of ultrafine anaphase bridges generated by homologous recombination" @default.
- W2893521651 cites W1593569677 @default.
- W2893521651 cites W1720819882 @default.
- W2893521651 cites W1920624926 @default.
- W2893521651 cites W1964616851 @default.
- W2893521651 cites W1965749659 @default.
- W2893521651 cites W1966302019 @default.
- W2893521651 cites W1970069044 @default.
- W2893521651 cites W1972932327 @default.
- W2893521651 cites W1980819419 @default.
- W2893521651 cites W1980830652 @default.
- W2893521651 cites W1987146639 @default.
- W2893521651 cites W1988052396 @default.
- W2893521651 cites W1988267044 @default.
- W2893521651 cites W1994419156 @default.
- W2893521651 cites W1996602584 @default.
- W2893521651 cites W2002495174 @default.
- W2893521651 cites W2006268714 @default.
- W2893521651 cites W2013846962 @default.
- W2893521651 cites W2016648136 @default.
- W2893521651 cites W2017382110 @default.
- W2893521651 cites W2021536045 @default.
- W2893521651 cites W2021717224 @default.
- W2893521651 cites W2027884659 @default.
- W2893521651 cites W2029468690 @default.
- W2893521651 cites W2037404897 @default.
- W2893521651 cites W2040083077 @default.
- W2893521651 cites W2046832453 @default.
- W2893521651 cites W2047292328 @default.
- W2893521651 cites W2047687247 @default.
- W2893521651 cites W2048106728 @default.
- W2893521651 cites W2049576185 @default.
- W2893521651 cites W2049598386 @default.
- W2893521651 cites W2049747606 @default.
- W2893521651 cites W2053779322 @default.
- W2893521651 cites W2067427915 @default.
- W2893521651 cites W2069572034 @default.
- W2893521651 cites W2070043307 @default.
- W2893521651 cites W2078438237 @default.
- W2893521651 cites W2079027867 @default.
- W2893521651 cites W2079185082 @default.
- W2893521651 cites W2081217876 @default.
- W2893521651 cites W2082447947 @default.
- W2893521651 cites W2087746152 @default.
- W2893521651 cites W2094078115 @default.
- W2893521651 cites W2096391864 @default.
- W2893521651 cites W2103972950 @default.
- W2893521651 cites W2109879947 @default.
- W2893521651 cites W2113678351 @default.
- W2893521651 cites W2114404734 @default.
- W2893521651 cites W2123215808 @default.
- W2893521651 cites W2126192932 @default.
- W2893521651 cites W2128940137 @default.
- W2893521651 cites W2128956771 @default.
- W2893521651 cites W2130972387 @default.
- W2893521651 cites W2145015866 @default.
- W2893521651 cites W2146204567 @default.
- W2893521651 cites W2149045141 @default.
- W2893521651 cites W2154484165 @default.
- W2893521651 cites W2167121797 @default.
- W2893521651 cites W2178382809 @default.
- W2893521651 cites W2197269124 @default.
- W2893521651 cites W2198940593 @default.
- W2893521651 cites W2417035212 @default.
- W2893521651 cites W2464252485 @default.
- W2893521651 cites W2508345834 @default.
- W2893521651 cites W2566141085 @default.
- W2893521651 cites W2591772585 @default.
- W2893521651 cites W2770589310 @default.
- W2893521651 cites W2771478014 @default.
- W2893521651 cites W2774408266 @default.
- W2893521651 cites W2782479280 @default.
- W2893521651 cites W2789128553 @default.
- W2893521651 cites W4253664160 @default.
- W2893521651 doi "https://doi.org/10.1080/15384101.2018.1515555" @default.
- W2893521651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6226235" @default.
- W2893521651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30253678" @default.
- W2893521651 hasPublicationYear "2018" @default.
- W2893521651 type Work @default.
- W2893521651 sameAs 2893521651 @default.
- W2893521651 citedByCount "25" @default.
- W2893521651 countsByYear W28935216512018 @default.
- W2893521651 countsByYear W28935216512019 @default.
- W2893521651 countsByYear W28935216512020 @default.
- W2893521651 countsByYear W28935216512021 @default.
- W2893521651 countsByYear W28935216512022 @default.
- W2893521651 countsByYear W28935216512023 @default.
- W2893521651 crossrefType "journal-article" @default.
- W2893521651 hasAuthorship W2893521651A5054117046 @default.
- W2893521651 hasAuthorship W2893521651A5081530748 @default.
- W2893521651 hasBestOaLocation W28935216511 @default.
- W2893521651 hasConcept C102744134 @default.