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• W2893523661 abstract "Abstract Microbial utilization of renewable one-carbon compounds, such as methane, methanol, formic acid, and CO 2 , has emerged as a potential approach to increase the range of carbon sources for bioproduction and address climate change issues. Here, we modify the natural serine cycle present in methylotrophs and build an adapted pathway for Escherichia coli , which allows microorganism to condense methanol (or formate) together with bicarbonate to produce various products. We introduce the modified cycle into E. coli and demonstrate its capability for one-carbon assimilation through growth complementation and isotope labeling experiments. We also demonstrate conversion of methanol to ethanol by utilizing the modified serine cycle in an engineered E. coli strain, achieving a reaction yet to be accomplished by a one-pot chemical process. This work provides a platform to utilize various renewable one-carbon compounds as carbon sources for biosynthesis through a modified serine cycle in E. coli ." @default.
• W2893523661 created "2018-10-05" @default.
• W2893523661 creator A5007847950 @default.
• W2893523661 creator A5075662890 @default.
• W2893523661 date "2018-09-28" @default.
• W2893523661 modified "2023-10-17" @default.
• W2893523661 title "A modified serine cycle in Escherichia coli coverts methanol and CO2 to two-carbon compounds" @default.
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• W2893523661 doi "https://doi.org/10.1038/s41467-018-06496-4" @default.
• W2893523661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162302" @default.
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• W2893523661 hasPublicationYear "2018" @default.
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