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- W2893524270 abstract "Abstract The cholesterol-lowering drug lovastatin corrects neurological phenotypes in animal models of fragile X syndrome (FX), a commonly identified genetic cause of autism and intellectual disability. The therapeutic efficacy of lovastatin is being tested in clinical trials for FX, however the structurally similar drug simvastatin has been proposed as an alternative due to an increased potency and brain penetrance. Here, we perform a side-by-side comparison of the effects of lovastatin and simvastatin treatment on two core phenotypes in the Fmr1 -/y mouse model. We find that while lovastatin normalizes excessive hippocampal protein synthesis and reduces audiogenic seizures (AGS) in the Fmr1 -/y mouse, simvastatin does not correct either phenotype. These results caution against the assumption that simvastatin is a valid alternative to lovastatin for the treatment of FX." @default.
- W2893524270 created "2018-10-05" @default.
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- W2893524270 date "2018-09-29" @default.
- W2893524270 modified "2023-09-26" @default.
- W2893524270 title "Lovastatin, not simvastatin, corrects core phenotypes in the fragile X mouse model" @default.
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- W2893524270 doi "https://doi.org/10.1101/430348" @default.
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