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• W2893527397 abstract "Trypanosoma cruzi epimastigotes internalize macromolecules avidly by endocytosis. Previously, we identified a tubule-vesicular network likely to correspond to the early-endosomes. However, a detailed ultrastructural characterization of these endosomes was missing. Here, we combined endocytosis assays with ultrastructural data from high-resolution electron microscopy to produce a 3D analysis of epimastigote endosomes and their interactions with endocytic organelles. We showed that endocytic cargo was found in carrier vesicles budding from the cytopharynx. These vesicles appeared to fuse with a tubule-vesicular network of early endosomes identified by ultrastructural features including the presence of intermembrane invaginations and coated membrane sections. Within the posterior region of the cell, endosomes localized preferentially on the side nearest to the cytopharynx microtubules. At 4°C, cargo accumulated at a shortened cytopharynx, and subsequent temperature shift to 12°C led to slow cargo delivery to endosomes and, later, to reservosomes. Bridges between reservosomes and endosomes resemble heterotypic fusion. Reservosomes are excluded from the posterior end of the cell, with no preferential cargo delivery to reservosomes closer to the nucleus. Our 3D analysis indicates that epimastigotes accomplish high-speed endocytic traffic by cargo transfer to a bona fide early-endosome and then directly from endosomes to reservosomes, via multiple and simultaneous heterotypic fusion events." @default.
• W2893527397 created "2018-10-05" @default.
• W2893527397 creator A5014123016 @default.
• W2893527397 creator A5033522638 @default.
• W2893527397 creator A5089461618 @default.
• W2893527397 date "2018-12-01" @default.
• W2893527397 modified "2023-10-01" @default.
• W2893527397 title "Tridimensional Electron Microscopy Analysis of the Early Endosomes and Endocytic Traffic in Trypanosoma cruzi Epimastigotes" @default.
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• W2893527397 doi "https://doi.org/10.1016/j.protis.2018.09.004" @default.
• W2893527397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30447618" @default.
• W2893527397 hasPublicationYear "2018" @default.
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