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- W2893538639 abstract "Human rotavirus vaccine Rotarix® (G1P[8]) has shown broad cross protection against homotypic and heterotypic Wa-like human rotavirus strains among children worldwide. This vaccine, however, appears to induce slightly less or non-consistent protection against DS-1 like rotavirus P[4] strains in some settings. In addition, children who are secretor or Lewis-negative and are vaccinated with Rotarix® often experience breakthrough infection with P[6] strains. By contrast, P[6] strains infect all children, irrespective of their secretor or Lewis status. In the present study, we report successful adaptation of a DS-1 like human rotavirus G9P[6] strain (CDC-6) to high growth in Vero cells and identify sequence changes that may be critical for enhanced growth in vitro and attenuation in vivo. This human G9P[6] strain could serve as a promising new and potential low-cost vaccine candidate for global use, particularly in targeted population with secretor or Lewis-negative status and high prevalent DS-1 like P[6] strains." @default.
- W2893538639 created "2018-10-05" @default.
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- W2893538639 date "2018-10-01" @default.
- W2893538639 modified "2023-09-26" @default.
- W2893538639 title "A DS-1 like G9P[6] human strain CDC-6 as a new rotavirus vaccine candidate" @default.
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- W2893538639 doi "https://doi.org/10.1016/j.vaccine.2018.08.055" @default.
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