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- W2893547464 abstract "Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR‑ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the first‑line agents for almost all CML patients. However, certain patients experience resistance to these medications, which occurs through several mechanisms, including the accumulation of TKI‑resistant chromosomal abnormalities. The present study reports a case of a 27‑year‑old Saudi male with CML receiving TKI treatment, who presented with precursor B‑cell lymphoblastic crisis demonstrating the presence of the novel combined chromosomal abnormalities; non‑Ph der(22), i(9) and der(20), carrying the BCR‑ABL1 fusion gene. This case report adds to the literature on novel TKI‑resistance‑conferring chromosomal abnormalities and links them to precursor B‑cell lymphoblastic crisis." @default.
- W2893547464 created "2018-10-05" @default.
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- W2893547464 date "2018-09-25" @default.
- W2893547464 modified "2023-10-01" @default.
- W2893547464 title "Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report" @default.
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- W2893547464 doi "https://doi.org/10.3892/ol.2018.9497" @default.
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