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• W2893548595 abstract "Zearalenone (ZEN) causes serious diseases in both animals and humans and thereby leads to substantial economic losses. The elimination of ZEN contamination from food and feed is an important concern worldwide. This study aimed to screen a bacterium that can efficiently detoxify ZEN both in vitro and in vivo. A bacterium (designated BC7) with high ZEN-removing capability was isolated from mouldy contaminated feeds and characterized as Bacillus cereus based on biochemical and 16S rRNA sequencing analyses. BC7 could remove 100% and 89.31% of 10 mg/L ZEN in Luria-Bertani (LB) medium and simulated gastric fluid (GSF), respectively, within 24 h at 37 °C. The effects of BC7 on ZEN detoxification and on the intestinal flora were further evaluated using four groups of mice that were intragastrically administered normal saline, BC7 culture (CFU = 3.45 × 108/mL), ZEN (10 mg/kg BW) or BC7 culture (CFU = 3.45 × 108/mL) + ZEN (10 mg/kg BW) for 2 weeks. ZEN showed distinct reproductive and hepatic toxicity, as characterized by increased weights of the uterus and liver, altered levels of oestradiol (E2) and luteinizing hormone (LH), increased secretion of the liver injury biomarkers alanine transaminase (ALT) and aspartate transaminase (AST), and abnormal histological phenotypes for the uterus, ovary and liver. However, BC7 could significantly reduce all the above-mentioned adverse effects caused by ZEN with no harmful effect on the reproductive system and liver in mice. Moreover, the addition of BC7 could efficiently renormalize the ZEN-induced perturbation of the gut microbiota and significantly increase the abundance of Lactobacillus to maintain the health of the intestinal flora in mice. In conclusion, Bacillus cereus BC7 could be used as a potential feed additive to efficiently remove ZEN in vitro or in vivo and to normalize the disordered gut microbiota in mice." @default.
• W2893548595 created "2018-10-05" @default.
• W2893548595 creator A5033632697 @default.
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• W2893548595 date "2018-12-01" @default.
• W2893548595 modified "2023-10-14" @default.
• W2893548595 title "Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of zearalenone removal and intestinal flora modulation in mice" @default.
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• W2893548595 doi "https://doi.org/10.1016/j.toxicon.2018.09.005" @default.
• W2893548595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267721" @default.
• W2893548595 hasPublicationYear "2018" @default.
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