Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893555307> ?p ?o ?g. }
- W2893555307 endingPage "223" @default.
- W2893555307 startingPage "215" @default.
- W2893555307 abstract "Previous studies indicate that the anti-hypoxia effects of Tibetan Turnip (Brassica rapa ssp. rapa) were closely related to its characteristic components being p-coumaric acid (CA) and p-coumaric acid‑β‑d‑glucopyranoside (CAG). Since CAG would be converted to CA in vivo, this study aims to further examine the efficacy and mechanism of CA against pulmonary edema induced by normobaric hypoxia.Male ICR mice were assigned to the normoxia group and several hypoxia groups, given sterile water, CA or dexamethasone orally, once daily for four consecutive days. One hour after the final gavage, mice in the above hypoxia groups were put into the normobaric hypoxia chamber (9.5% O2) for 24 h while mice in normoxia group remained outside the chamber. After hypoxia exposure, lung water content (LWC), pulmonary vascular permeability, the protein content of bronchoalveolar lavage fluid (BALF), plasma total nitrate/nitrite (NOx) and endothelin-1 (ET-1) content, histological and ultra-microstructure analyses were performed. Expression of occludin was assayed by immunohistochemistry.In a hypoxic environment of 9.5% O2, mice treated with 100 mg/kg body wt CA had significantly lower LWC and BALF protein content than mice in the hypoxia vehicle group. Meanwhile, mice in CA group showed intact lung blood-gas-barrier, increased levels of plasma total NO, decreased levels of plasma ET-1 and upregulation of occludin expression.CA exerts preventive effects against normobaric hypoxic pulmonary edema in mice, its mechanisms involved improving the integrity of the lung barrier, inhibiting oxidative stress and inflammation." @default.
- W2893555307 created "2018-10-05" @default.
- W2893555307 creator A5006804238 @default.
- W2893555307 creator A5034363096 @default.
- W2893555307 creator A5035252474 @default.
- W2893555307 creator A5042973046 @default.
- W2893555307 creator A5047932411 @default.
- W2893555307 creator A5062924912 @default.
- W2893555307 date "2018-10-01" @default.
- W2893555307 modified "2023-10-16" @default.
- W2893555307 title "p-Coumaric acid as a prophylactic measure against normobaric hypoxia induced pulmonary edema in mice" @default.
- W2893555307 cites W1965065789 @default.
- W2893555307 cites W1989719444 @default.
- W2893555307 cites W1993250846 @default.
- W2893555307 cites W1993324234 @default.
- W2893555307 cites W1998189725 @default.
- W2893555307 cites W2001643534 @default.
- W2893555307 cites W2005408613 @default.
- W2893555307 cites W2006773206 @default.
- W2893555307 cites W2009797189 @default.
- W2893555307 cites W2024806757 @default.
- W2893555307 cites W2026799616 @default.
- W2893555307 cites W2031967068 @default.
- W2893555307 cites W2035881395 @default.
- W2893555307 cites W2039219549 @default.
- W2893555307 cites W2039603495 @default.
- W2893555307 cites W2041265488 @default.
- W2893555307 cites W2045482902 @default.
- W2893555307 cites W2060789691 @default.
- W2893555307 cites W2075430896 @default.
- W2893555307 cites W2092238688 @default.
- W2893555307 cites W2097483508 @default.
- W2893555307 cites W2109618496 @default.
- W2893555307 cites W2126357549 @default.
- W2893555307 cites W2140639123 @default.
- W2893555307 cites W2141009479 @default.
- W2893555307 cites W2141818933 @default.
- W2893555307 cites W2145237733 @default.
- W2893555307 cites W2173035891 @default.
- W2893555307 cites W2341105818 @default.
- W2893555307 cites W2547438271 @default.
- W2893555307 cites W2556883840 @default.
- W2893555307 cites W2590651547 @default.
- W2893555307 cites W2607000416 @default.
- W2893555307 cites W2725672852 @default.
- W2893555307 cites W2748435152 @default.
- W2893555307 cites W2752958596 @default.
- W2893555307 cites W988777830 @default.
- W2893555307 cites W2133282929 @default.
- W2893555307 doi "https://doi.org/10.1016/j.lfs.2018.09.039" @default.
- W2893555307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248349" @default.
- W2893555307 hasPublicationYear "2018" @default.
- W2893555307 type Work @default.
- W2893555307 sameAs 2893555307 @default.
- W2893555307 citedByCount "13" @default.
- W2893555307 countsByYear W28935553072019 @default.
- W2893555307 countsByYear W28935553072021 @default.
- W2893555307 countsByYear W28935553072022 @default.
- W2893555307 countsByYear W28935553072023 @default.
- W2893555307 crossrefType "journal-article" @default.
- W2893555307 hasAuthorship W2893555307A5006804238 @default.
- W2893555307 hasAuthorship W2893555307A5034363096 @default.
- W2893555307 hasAuthorship W2893555307A5035252474 @default.
- W2893555307 hasAuthorship W2893555307A5042973046 @default.
- W2893555307 hasAuthorship W2893555307A5047932411 @default.
- W2893555307 hasAuthorship W2893555307A5062924912 @default.
- W2893555307 hasConcept C126322002 @default.
- W2893555307 hasConcept C134018914 @default.
- W2893555307 hasConcept C177779419 @default.
- W2893555307 hasConcept C178790620 @default.
- W2893555307 hasConcept C185592680 @default.
- W2893555307 hasConcept C2775962179 @default.
- W2893555307 hasConcept C2776468924 @default.
- W2893555307 hasConcept C2777714996 @default.
- W2893555307 hasConcept C2777961210 @default.
- W2893555307 hasConcept C2780401358 @default.
- W2893555307 hasConcept C2780886150 @default.
- W2893555307 hasConcept C29323129 @default.
- W2893555307 hasConcept C540031477 @default.
- W2893555307 hasConcept C55493867 @default.
- W2893555307 hasConcept C71924100 @default.
- W2893555307 hasConcept C7836513 @default.
- W2893555307 hasConcept C98274493 @default.
- W2893555307 hasConceptScore W2893555307C126322002 @default.
- W2893555307 hasConceptScore W2893555307C134018914 @default.
- W2893555307 hasConceptScore W2893555307C177779419 @default.
- W2893555307 hasConceptScore W2893555307C178790620 @default.
- W2893555307 hasConceptScore W2893555307C185592680 @default.
- W2893555307 hasConceptScore W2893555307C2775962179 @default.
- W2893555307 hasConceptScore W2893555307C2776468924 @default.
- W2893555307 hasConceptScore W2893555307C2777714996 @default.
- W2893555307 hasConceptScore W2893555307C2777961210 @default.
- W2893555307 hasConceptScore W2893555307C2780401358 @default.
- W2893555307 hasConceptScore W2893555307C2780886150 @default.
- W2893555307 hasConceptScore W2893555307C29323129 @default.
- W2893555307 hasConceptScore W2893555307C540031477 @default.
- W2893555307 hasConceptScore W2893555307C55493867 @default.
- W2893555307 hasConceptScore W2893555307C71924100 @default.