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- W2893556097 endingPage "154" @default.
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- W2893556097 abstract "Hallucinogenic drugs potently alter human behavior and have a millennia-long history of use for medicinal and religious purposes. Interest is rapidly growing in their potential as CNS modulators and therapeutic agents for brain conditions. Antimuscarinic cholinergic drugs, such as atropine and scopolamine, induce characteristic hyperactivity and dream-like hallucinations and form a separate group of hallucinogens known as “deliriants”. Although atropine and scopolamine are relatively well-studied drugs in cholinergic physiology, deliriants represent the least-studied class of hallucinogens in terms of their behavioral and neurological phenotypes. As such, novel approaches and new model organisms are needed to investigate the CNS effects of these compounds. Here, we comprehensively evaluate the preclinical effects of deliriant hallucinogens in various animal models, their mechanisms of action, and potential interplay with other signaling pathways. We also parallel experimental and clinical findings on deliriant agents and outline future directions of translational research in this field." @default.
- W2893556097 created "2018-10-05" @default.
- W2893556097 creator A5001115050 @default.
- W2893556097 creator A5013576957 @default.
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- W2893556097 creator A5049468217 @default.
- W2893556097 creator A5060931486 @default.
- W2893556097 creator A5078471754 @default.
- W2893556097 date "2018-09-25" @default.
- W2893556097 modified "2023-09-29" @default.
- W2893556097 title "Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models" @default.
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