Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893556768> ?p ?o ?g. }
- W2893556768 endingPage "5076" @default.
- W2893556768 startingPage "5070" @default.
- W2893556768 abstract "Abstract Esophageal squamous cell carcinoma (ESCC) is among the leading causes of cancer related death. Despite of extensive efforts in identifying valid cancer prognostic biomarkers, only a very small number of markers have been identified. Several genetic variants in the 9p21 region have been identified that are associated with the risk of multiple cancers. Here, we explored the association of two genetic variants in the 9p21 region, CDKN2A/B, rs10811661, and rs1333049 for the first time in 273 subjects with, or without ESCC. We observed that the patients with ESCC had a higher frequency of a TT genotype for rs10811661 than individuals in the control group, and this polymorphism was also associated with tumor size. Moreover, a CC genotype for the rs1333049 polymorphism was associated with a reduced overall survival (OS) of patients with ESCC. In particular, patients with a CC (rs1333049) genotype had a significantly shorter OS (CC genotype: 34.5 ± 8.9 months vs. CG+GG: 47.7 ± 5.9 months; p value = 0.03). We have also shown the association of a novel genetic variant in CDKN2B gene with clinical outcome of patients with ESCC. Further investigations are warranted in a larger population to explore the value of emerging markers as a risk stratification marker in ESCC." @default.
- W2893556768 created "2018-10-05" @default.
- W2893556768 creator A5000238978 @default.
- W2893556768 creator A5002434919 @default.
- W2893556768 creator A5006098830 @default.
- W2893556768 creator A5006924252 @default.
- W2893556768 creator A5007239997 @default.
- W2893556768 creator A5008171226 @default.
- W2893556768 creator A5014419683 @default.
- W2893556768 creator A5015576631 @default.
- W2893556768 creator A5021412312 @default.
- W2893556768 creator A5035222830 @default.
- W2893556768 creator A5048087541 @default.
- W2893556768 creator A5062327941 @default.
- W2893556768 creator A5065961401 @default.
- W2893556768 creator A5079331595 @default.
- W2893556768 creator A5082730118 @default.
- W2893556768 creator A5086800490 @default.
- W2893556768 creator A5089967609 @default.
- W2893556768 date "2018-09-21" @default.
- W2893556768 modified "2023-10-15" @default.
- W2893556768 title "A genetic variant in <i>CDKN2A/2B</i> locus was associated with poor prognosis in patients with esophageal squamous cell carcinoma" @default.
- W2893556768 cites W1580092175 @default.
- W2893556768 cites W1856228646 @default.
- W2893556768 cites W19656460 @default.
- W2893556768 cites W1968210590 @default.
- W2893556768 cites W1969204301 @default.
- W2893556768 cites W1986212196 @default.
- W2893556768 cites W2002369796 @default.
- W2893556768 cites W2003723466 @default.
- W2893556768 cites W2005400333 @default.
- W2893556768 cites W2006316372 @default.
- W2893556768 cites W2008718063 @default.
- W2893556768 cites W2010573862 @default.
- W2893556768 cites W2015871659 @default.
- W2893556768 cites W2016749216 @default.
- W2893556768 cites W2017667973 @default.
- W2893556768 cites W2020860086 @default.
- W2893556768 cites W2021717793 @default.
- W2893556768 cites W2036307272 @default.
- W2893556768 cites W2049621625 @default.
- W2893556768 cites W2052741109 @default.
- W2893556768 cites W2067273727 @default.
- W2893556768 cites W2067782223 @default.
- W2893556768 cites W2070252780 @default.
- W2893556768 cites W2080500842 @default.
- W2893556768 cites W2081512227 @default.
- W2893556768 cites W2094703974 @default.
- W2893556768 cites W2097039402 @default.
- W2893556768 cites W2102850127 @default.
- W2893556768 cites W2110899026 @default.
- W2893556768 cites W2138450577 @default.
- W2893556768 cites W2142970835 @default.
- W2893556768 cites W2149060273 @default.
- W2893556768 cites W2265032271 @default.
- W2893556768 cites W2342096484 @default.
- W2893556768 cites W2471214823 @default.
- W2893556768 cites W2482864649 @default.
- W2893556768 cites W2566094762 @default.
- W2893556768 doi "https://doi.org/10.1002/jcp.27310" @default.
- W2893556768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30238987" @default.
- W2893556768 hasPublicationYear "2018" @default.
- W2893556768 type Work @default.
- W2893556768 sameAs 2893556768 @default.
- W2893556768 citedByCount "14" @default.
- W2893556768 countsByYear W28935567682019 @default.
- W2893556768 countsByYear W28935567682020 @default.
- W2893556768 countsByYear W28935567682021 @default.
- W2893556768 countsByYear W28935567682022 @default.
- W2893556768 countsByYear W28935567682023 @default.
- W2893556768 crossrefType "journal-article" @default.
- W2893556768 hasAuthorship W2893556768A5000238978 @default.
- W2893556768 hasAuthorship W2893556768A5002434919 @default.
- W2893556768 hasAuthorship W2893556768A5006098830 @default.
- W2893556768 hasAuthorship W2893556768A5006924252 @default.
- W2893556768 hasAuthorship W2893556768A5007239997 @default.
- W2893556768 hasAuthorship W2893556768A5008171226 @default.
- W2893556768 hasAuthorship W2893556768A5014419683 @default.
- W2893556768 hasAuthorship W2893556768A5015576631 @default.
- W2893556768 hasAuthorship W2893556768A5021412312 @default.
- W2893556768 hasAuthorship W2893556768A5035222830 @default.
- W2893556768 hasAuthorship W2893556768A5048087541 @default.
- W2893556768 hasAuthorship W2893556768A5062327941 @default.
- W2893556768 hasAuthorship W2893556768A5065961401 @default.
- W2893556768 hasAuthorship W2893556768A5079331595 @default.
- W2893556768 hasAuthorship W2893556768A5082730118 @default.
- W2893556768 hasAuthorship W2893556768A5086800490 @default.
- W2893556768 hasAuthorship W2893556768A5089967609 @default.
- W2893556768 hasBestOaLocation W28935567682 @default.
- W2893556768 hasConcept C104317684 @default.
- W2893556768 hasConcept C121608353 @default.
- W2893556768 hasConcept C126322002 @default.
- W2893556768 hasConcept C135763542 @default.
- W2893556768 hasConcept C143998085 @default.
- W2893556768 hasConcept C2779742542 @default.
- W2893556768 hasConcept C2780265364 @default.
- W2893556768 hasConcept C2908647359 @default.
- W2893556768 hasConcept C2994415158 @default.